Heavy metal exposure causes changes in the metabolic health-associated gut microbiome and metabolites

Li, Xuanji; Brejnrod, Asker; Ernst, Madeleine; Rykær, Martin; Herschend, Jakob; Olsen, Nanna Mee Coops; Dorrestein, Pieter C.; Rensing, Christopher; Sørensen, Søren J.

doi:10.1016/j.envint.2019.02.048

Cited by 154 publications

(65 citation statements)

References 58 publications

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“…Realgar treatment decreased the abundance of Firmicutes and increased the abundance of Bacteroidetes in a dose-dependent manner [ 42 ]. Several genera in Firmicutes, such as Lactobacillus and Faecalibacterium , were observed to decrease following arsenic exposure [ 42 , 52 ]. Lactobacillus was beneficial in minimizing or preventing the adherence of xenobiotics to the surface of intestinal mucosa [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice

Zhang

Jiang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the influence of gut microbiota on arsenic accumulation of realgar in mice. Methods. Mice were treated with antibiotics to form a mouse model of gut microbial disruption. Antibiotic-treated and normally raised mice were given 15 mg/kg, 150 mg/kg, and 750 mg/kg realgar by gavage and 0.2 mg/kg and 1 mg/kg arsenic solution by subcutaneous injection for 7 days. The concentration of arsenic in mice whole blood was determined by inductively coupled plasma mass spectrometry (ICP-MS). Arsenic accumulation in antibiotic-treated mice and normally raised mice was compared. Results. After exposure to low dose (15 mg/kg) and middle dose (150 mg/kg) of realgar, significantly, more arsenic was accumulated in the whole blood of antibiotic-treated mice compared to normally raised counterparts, which indicated that the disruption of gut microbiota could lead to higher arsenic load of realgar in mice. The homeostasis of gut microbiota was supposed to be disrupted by high dose (750 mg/kg) of realgar because after exposure to high dose of realgar, there was no significant difference in arsenic accumulation between antibiotic-treated and normally raised mice. Furthermore, arsenic solution was administered by subcutaneous injection to mice to investigate the influence of gut microbial differences on arsenic accumulation in addition to the absorption process, and there was no significant difference in arsenic accumulation between mice with these two different statuses of gut microbiota. Conclusions. Gut microbiota disruption could increase arsenic accumulation of realgar in mice.

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Section: Resultsmentioning

confidence: 99%

Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice

Zhang

Jiang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The effects of arsenic on the microbiome appeared to be unique when compared with other environmental metal and metalloid toxicants [125,132]. However, there is little similarity in compositional shifts during arsenic exposures in different studies.…”

Section: Arsenic Perturbation Of the Microbiomementioning

confidence: 97%

The Human Gut Microbiome’s Influence on Arsenic Toxicity

2019

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Purpose of Review Arsenic exposure is a public health concern of global proportions with a high degree of interindividual variability in pathologic outcomes. Arsenic metabolism is a key factor underlying toxicity, and the primary purpose of this review is to summarize recent discoveries concerning the influence of the human gut microbiome on the metabolism, bioavailability, and toxicity of ingested arsenic. We review and discuss the current state of knowledge along with relevant methodologies for studying these phenomena. Recent Findings Bacteria in the human gut can biochemically transform arsenic-containing compounds (arsenicals). Recent publications utilizing culture-based approaches combined with analytical biochemistry and molecular genetics have helped identify several arsenical transformations by bacteria that are at least possible in the human gut and are likely to mediate arsenic toxicity to the host. Other studies that directly incubate stool samples in vitro also demonstrate the gut microbiome's potential to alter arsenic speciation and bioavailability. In vivo disruption or elimination of the microbiome has been shown to influence toxicity and body burden of arsenic through altered excretion and biotransformation of arsenicals. Currently, few clinical or epidemiological studies have investigated relationships between the gut microbiome and arsenic-related health outcomes in humans, although current evidence provides strong rationale for this research in the future. Summary The human gut microbiome can metabolize arsenic and influence arsenical oxidation state, methylation status, thiolation status, bioavailability, and excretion. We discuss the strength of current evidence and propose that the microbiome be considered in future epidemiologic and toxicologic studies of human arsenic exposure.

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“…All studies on humans or different animal models or in vitro, concerning investigations of ≥2 heavy metals, are concordant in concluding that heavy metal exposure, even if for a short period of time, can cause perturbations in the composition, structure and diversity of the GM. The majority of the studies used the amplification and sequencing of the 16S rRNA gene for the microbial community analysis; only 2 studies (16,17), proceeded with metabolomics approach demonstrating that As, Cd and selenate also influenced several metabolic pathways. When investigated together, different toxicants may interact and their effects, on GM or on health status, could be potentiated.…”

Section: Data Collection and Analysismentioning

confidence: 99%

“…Li et al treated mice with Cd chloride and As in their drinking water for 2 weeks. Colon and caecum content were collected and 16S rRNA gene was sequenced (16). Both As and Cd significantly perturbed the metabolome and lowered the GM diversity; however, only Cd significantly decreased the microbial diversity.…”

Section: Data Collection and Analysismentioning

confidence: 99%

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Influence of toxic metal exposure on the gut microbiota (Review)

et al. 2021

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The gut microbiota (GM) is composed of >100 trillion different organisms, including bacteria, viruses, fungi, archaea and protists, coexisting in a complex system. The GM can be very sensitive to drugs, diet or even environmental pollutants. In the present review, recent data related to the interaction between the GM and heavy/toxic metals are discussed, focusing on the compounds most widely distributed in the environment or considered biopersistent. There are data to suggest that exposure to metals can alter the composition, diversity, homogeneity and structure of the GM. The specific modifications reported are not homogeneous, and a number of factors may explain this variability, including differences in metal compound, exposure modalities (e.g., food, water, in vitro), exposure time, qualitative and quantitative diversity of bacterial species in basal microbiota and analytical issues. As regards metal nanoparticles, some authors foresee the premises for a safe preventive and therapeutic use, while others have revealed harmful effects on both the gut microbiome and health. These findings, which would benefit from the application of modern approaches such as metagenomic sequencing and metabolomics, seem to indicate structural and functional analysis of gut microbiota as an early biomarker of detrimental effects from exposure to metals.

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Heavy metal exposure causes changes in the metabolic health-associated gut microbiome and metabolites

Cited by 154 publications

References 58 publications

Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice

Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice

The Human Gut Microbiome’s Influence on Arsenic Toxicity

Influence of toxic metal exposure on the gut microbiota (Review)

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