We extend the two-flavor hard-wall holographic model of Erlich, Katz, Son and Stephanov [Phys. Rev. Lett. 95, 261602 (2005)] to four flavors to incorporate strange and charm quarks. The model incorporates chiral and flavor symmetry breaking and provides a reasonable description of masses and weak decay constants of a variety of scalar, pseudoscalar, vector and axial-vector strange and charmed mesons. In particular, we examine flavor symmetry breaking in the strong couplings of the ρ meson to the charmed D and D * mesons. We also compute electromagnetic form factors of the π, ρ, K, K * , D and D * mesons. We compare our results for the D and D * mesons with lattice QCD data and other nonperturbative approaches.