Heidenhain Pouch Response to Antral Stimulation before and after Antral Denervation in Dogs

Emås, Sverre; Vagne, M; Grossman, Morton I.

doi:10.3181/00379727-132-34387

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…Their findings indicated that acid production in response to a test meal was no greater in patients with a vagally innervated antrum than in patients with a vagally denervated antrum when the antrum was maintained in continuity with the fundus. These findings confirmed the early work of Grossman et al (16), who demonstrated that release of gastrin by chemical agents acting locally in the antrum was not dependent upon intact vagal innervation, but contradict the studies of Emas (17), who showed that denervation of the antrum reduced acid secretion from denervated parietal cells when the antrum was stimulated.…”

Section: Potential Advantages Of Pevsupporting

confidence: 87%

Parietal Cell Vagotomy without Drainage for the Treatment of Duodenal Ulcer

Ph¹

1976

Annu. Rev. Med.

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PVC without drainage for the treatment of duodenal ulcer is a safe procedure. There are fewer gastrointestinal complaints of the type frequently observed after more orthodox gastric surgery. Diarrhea and dumping may be noted after PCV but the incidence of both is less, and when they do occur they are milder and more easily controlled than after other types of operations. The ultimate recurrent ulcer rate remains unresolved because insufficient time for observation and follow-up has elapsed. Since most recurrent ulcers that occur after other gastric procedures present within the first two years after operation, the documentation by several authors of a recurrent ulcer rate of 2-4% in patients followed two to four years after operation suggests that PCV is a highly effective procedure. Yet the high recurrence rates of 22% reported by one group indicates that the operation is not highly effective for everyone. The factors responsible for the discrepancy between the high and low recurrence rates reported by different authors are not evident at this time.

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Section: Potential Advantages Of Pevsupporting

confidence: 87%

Parietal Cell Vagotomy without Drainage for the Treatment of Duodenal Ulcer

Ph¹

1976

Annu. Rev. Med.

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“…In the dogs with denervatfd pouches, the increased response to food following complete vagotomy is similar to that described in dogs with intact antra (Emas and Crossman, 1969;Evans et ai, 1953;Kanar and Harkins, 1953;Lawson and Dragstedt, 1968;Storer et ai, 1952). That this change occurred despite previous antral denervation is in keeping with the view that it results from a reduetion in the inhibiting effect of acid on gastrin release consequent upon a decrease in the amount of acid secreted by the main stomach (Grossman, 1960).…”

Section: Discussionsupporting

confidence: 62%

Effect of Denervation of Pyloric Antrum on the Gastric Secretory Response to Food

Hunt¹,

Forrest²

1975

Aust J Exp Biol Med

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Summary. The effect of selective denervation of the pyloric antrum on secretory respon.se to three types of food was determined in 3 dogs with innervated and 4 with denervated stomach pouches. With the antrmii in situ this procedure has .surprisingly little eHect on the total meal responses in innervated pouches, on the variation in response induced by altered buffering capacity of the meals, or on the effect of subsequent vagotomy. However, the antrum appears less sensitive to local stimuli after denervation, as evidenced by the reduced meal response from the denervated indicator pouch after denervation of the antrum.INTRODUCTION.

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“…Thirdly, the studies presented in this paper demonstrate that the hypergastrinaemia associated with duodenal ulceration is abolished by "medical" or surgical vagotomy. There have not, as yet, been any studies in man to determine the effect of vagotomy on the gastrin content of antral tissue but it has been shown in dogs 19 that extrinsic antral denervation significantly decreases the gastrin response following stimulation by antral perfusion with acetylcholine. Since the stimulus used in these studies was maximal, and involved the parasympathetic neurotransmitter substance (which acts directly on the gastrin secreting cells) the decrease in gastrin response could not (as the authors suggest) have been due to the loss of a "fa~ilitated release" but must have represented a decrease in the releasable gastrin; indicating that denervation (vagal) does decrease the antral content of gastrin.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vagotomy on Serum Gastrin in Patients with Duodenal Ulceration

Lazarus

1970

Australasian Annals of Medicine

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Summary The concept of increased vagal activity in patients with duodenal ulceration was investigated by observing the effect of medical and surgical vagotomy on the secretion of gastrin. Using a radioimmunoassay technique fasting serum levels of gastrin were determined in 41 normal subjects, 40 patients with duodenal ulceration and 16 patients following vagotomy. The effect of atropine on gastrin secretion was observed in a further 2 patients with duodenal ulceration. The patients with duodenal ulceration were found to have elevated serum levels of gastrin. The 8 patients with “complete” vagotomy had significantly lower serum levels of gastrin than the patients with duodenal ulceration, the patients with an “incomplete” vagotomy or the normal subjects. Post‐vagotomy hypergastrinaemia was associated with a recurrence of ulceration. The abolition, by medical or surgical vagotomy, of the hypergastrinaemia associated with duodenal ulceration is consistent with the hypothesis of an increased vagal tone in this disease. These studies also suggest that gastrin estimations may be useful in predicting the presence of inadequate vagotomies.

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Heidenhain Pouch Response to Antral Stimulation before and after Antral Denervation in Dogs

Cited by 14 publications

References 5 publications

Parietal Cell Vagotomy without Drainage for the Treatment of Duodenal Ulcer

Parietal Cell Vagotomy without Drainage for the Treatment of Duodenal Ulcer

Effect of Denervation of Pyloric Antrum on the Gastric Secretory Response to Food

Effect of Vagotomy on Serum Gastrin in Patients with Duodenal Ulceration

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