Helicobacter pylori in patients with gastritis in West Cameroon: prevalence and risk factors for infection

Agbor, Nathan E.; Esemu, Seraphine Nkie; Ndip, Lucy; Tanih, Nicoline F.; Smith, Stella I.; Ndip, Roland N.

doi:10.1186/s13104-018-3662-5

Cited by 24 publications

(37 citation statements)

References 26 publications

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“…The prevalence of sex in female was 60.8% which was high compared to males 39.23% and this is almost similar to the study in Assosa General Hospital West Ethiopia (17) and it is also in another study the proportion of females is compared to male prevalence was higher (13,18). But this study is in consistent with another study in Giggiga university Somalia regional states of Ethiopia.…”

Section: Discussionsupporting

confidence: 89%

Prevalence of Helicobacter Pylori Infection and Associated Factors Among Gastritis Patents in Yekatit 12 Teaching Hospital Addis Ababa Ethiopia

Hailu¹,

Sileshi²,

Panari³

2020

Preprint

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Introduction: Helicobacter pylori colonize the stomach of about ~50% of the world’s human population and infection is more in clients with dyspeptic conditions and its associated with the severity of gastritis. The present study revealed that the magnitude of H. Pylori and burden of the bacterial infection as well as the contribution of H. Pylori for gastritis and also assesses the current prevalence of H. Pylori infection.Objective: To evaluate the prevalence of Helicobacter Pylori infection and associated factors among gastritis patents in Yekatit 12 Hospital.Methodology: An institutional based cross-sectional study was conducted in Yekatit 12 teaching hospital Addis Ababa city, Ethiopia. The participants were those patients come to the hospital for treatment of gastritis and send to the laboratory to confirm Helicobacter pylori infection in the data collection period. A total of 394 participants were interviewed by using a structured pre tested questionnaire. The data were coded and entered into Epi Data 3.1 version , cleaned and exported to version 20, SPSS. Multiple Logistic regression was used to estimate Adjusted (AORs) with a 95% confidence interval (CI) of positive responses to the different risk factors. P-value < 0.05 was considered as significant.Result: The total occurrence of H. Pylori in observers was 25.9%. Regarding income of family, those participants who have less income and living in rural areas were extra prone to be infected with H. Pylori (AOR=5.857, CI 95% = 1.389-24.686, P = 0.016 and AOR=3.663, CI 95% = 1.068-12.557, P =0.039) respectively. Further, the prevalence of study was significant association with participants who had experience of gastrointestinal illness, mouth to mouth kissing, unable to hand wash regularly before meal and after latrine used (AOR=4.270, 95%CI=1.785-10.21, P=0.01, AOR=53.085, 95%CI=16.185-174.114, P=0.000, AOR=7.316, 95%CI=1.944-27.536, P=0.003, AOR=3.374, 95%CI=1.024-11.114, P=0.046) respectively.Conclusion and recommendation: The finding shows that H. Pylori infection was significantly associated with occupational status,gender, smoking tobacco and hand washing regularly before meal and after toilet. I recommend making clean and saving the work place; regular hand wash, before food preparation, before feeding and after latrine. A health professional should give health education by using different media about the transition and health biro also should give emphases.

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Section: Discussionsupporting

confidence: 89%

Prevalence of Helicobacter Pylori Infection and Associated Factors Among Gastritis Patents in Yekatit 12 Teaching Hospital Addis Ababa Ethiopia

Hailu¹,

Sileshi²,

Panari³

2020

Preprint

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“…Many of these acid-resistant bacteria have the capacity to produce some type of SCFAs, which changes the production and finally the proportion of SCFAs ( Supplementary Figure 5). Meanwhile, the dominant growth of these beneficial bacteria reduces some harmful or acid-sensitive bacteria, similar to the reduction of Helicobacter, Campylobacter, and Bifidobacterium observed in this study [27,28] (Supplementary Figure 6).…”

Section: Discussionsupporting

confidence: 83%

Low and high concentrations of butyrate regulate fat accumulation in chicken adipocytes via different mechanisms

et al. 2020

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The present study investigated the effects of varying concentrations of sodium butyrate (SB) on fat accumulation and cell proliferation in chicken adipocytes. High and low serial concentrations of SB used significantly reduced adipocytic fat accumulation. However, they were observed to exhibit differences in cell morphology and distinctions in lipogenic genes expression profiles. At lower concentration (0.01 mM), fat accumulation was decreased with an associated downregulation in the expression of lipogenic genes, which was mediated by free fatty acid receptors (FFARs). Contarily, at higher concentration (1 mM), the fat droplets laden in adipocytes were enlarged, and this was accompanied with activation of lipogenic genes expression. However, the total accumulated fat was also decreased largely due to reduction in cell numbers, which was partially attributable to the reduction in histone deacetylase (HDAC) activity. Animal experiments further indicated that dietary supplementation of lower dose coated SB (0.1% wt/wt) inhibited fat deposition in livers and abdominal fat tissues of broilers, suggesting the potential application of sodium butyrate as feed additive in the regulation of fat deposition.

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“…The risk factors for H. pylori infection are sex (10) , age (11,12) , smoking (13) , alcohol consumption (14) , contaminated food (12) , untreated water intake (5) , family size (15) , bed sharing (16) , poor living conditions in childhood (17) , educational (13) and socioeconomic level (18) , hygiene (19) , and family medical history of gastric disease (11) .…”

Section: Introductionmentioning

confidence: 99%

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

Borges

Ramos

Filho

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: In Brazil, particularly in the underdeveloped localities, the prevalence of Helicobacter pylori (H. pylori) infections can range up to 90%. These rates are higher in older individuals and vary by country region. H. pylori infections are linked to the development of gastric pathologies, namely mild to moderate gastritis, gastroenteritis, peptic ulcer, intestinal metaplasia, and gastric cancer. In 1994, this organism was classified by the International Agency for Research on Cancer (IARC) as pertaining to the Group 1 carcinogen for gastric adenocarcinoma etiology. Gastric cancer represents a significant public health problem, being the fourth most common malignant tumor and the second largest cause of cancer-related deaths. OBJECTIVE: To investigate the prevalence of H. pylori infection in dyspeptic patients and determine the link between clinical risk factors and gastric adenocarcinoma diagnosis. METHODS: Polymerase chain reaction (PCR) analysis was employed for molecular diagnosis of gastric tissue biopsies collected from 113 dyspeptic patients at the University Hospital of Federal University of Goiás. Molecular analyses allowed the identification of H. pylori infections. Furthermore, histopathological examinations were performed to determine the clinical risks of developing gastric malignancies. RESULTS: The test results identified 69 individuals older than 44 years, from 75 (66.4%) positive H. pylori infection samples. The prevalence of gastric adenocarcinoma in this study was 1.3%. Among the infected patients, six (8.2%) had high risk, and 67 (91.8%) had a low risk of developing gastric cancer (P<0.05). CONCLUSION: This study shows a high prevalence of H. pylori infection and identifies its contribution to gastric inflammations, which in the long term are manifested in high-risk clinical factors for the development of gastric adenocarcinoma.

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Helicobacter pylori in patients with gastritis in West Cameroon: prevalence and risk factors for infection

Cited by 24 publications

References 26 publications

Prevalence of Helicobacter Pylori Infection and Associated Factors Among Gastritis Patents in Yekatit 12 Teaching Hospital Addis Ababa Ethiopia

Prevalence of Helicobacter Pylori Infection and Associated Factors Among Gastritis Patents in Yekatit 12 Teaching Hospital Addis Ababa Ethiopia

Low and high concentrations of butyrate regulate fat accumulation in chicken adipocytes via different mechanisms

[Article Partial Retraction] Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients and Its Association With Clinical Risk Factors for Developing Gastric Adenocarcinoma

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