Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells

Targosz, Aneta; Brzozowski, Tomasz; Pierzchalski, Piotr; Szczyrk, Urszula; Ptak‐Belowska, Agata; Konturek, Stanisław J.; Pawlik, Wiesław W.

doi:10.1007/s00011-012-0487-x

Cited by 43 publications

(29 citation statements)

References 48 publications

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“…Tumorigenic pathogens or persistent infections are able to boost the host immunity and cause continuous inflammation to initiate carcinogenesis. For instance, it was considered that persistent Helicobacter pylori infection was associated with the pathogenesis of gastric cancer and mucosa-associated lymphoid tissue lymphoma [57], hepatitis B or C viruses with hepatocellular carcinoma, or Schistosoma or Bacteroides species with bladder and colon cancer, respectively [58]. Consistent inflammation can induce the occurrence of autoimmunity, oncogenic mutations, genomic instability, early tumor promotion, or angiogenesis.…”

Section: Roles Of Chemokines In Cancer-related Inflammationmentioning

confidence: 99%

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Shi

Wang

Hou

et al. 2015

Cancer Metastasis Rev

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Inflammatory cells and mediators are essential components in tumor microenvironment and play decisive roles in the initiation, proliferation, survival, promotion, invasion, or metastasis of lung cancer. Clinical and epidemiologic studies suggested a strong association between inflammation and lung cancer and an influence of immune surveillances and tumor responses to chemotherapeutic drugs, although roles of inflammation in lung cancer remain unclear. The present review outlined roles of inflammation in lung cancer, with particular focus on inflammatory components, types, biomarkers, or principal mechanisms by which the inflammation contributes to the development of lung cancer. The cancer-associated inflammatory cells (CICs) should be furthermore defined and include cancer-specific and interacted cells with inflammatory or inflammation-like characteristics, e.g., innate or adaptive immune cells and cancer tissue cells. We also discuss targeting potentials of inflammation in the prevention and treatment of lung cancer. The diversity of cancer-related inflammatory microenvironment is instrumental to design novel therapeutic approaches for lung cancer.

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Section: Roles Of Chemokines In Cancer-related Inflammationmentioning

confidence: 99%

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Shi

Wang

Hou

et al. 2015

Cancer Metastasis Rev

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“…This is accompanied by a shift towards a proapoptotic homeostasis with increased expression of bax and decreased expression of bcl2 [199,200]. The induction of oncogenes like cmyc is also interfering with these processes [199,201].…”

Section: Response To H Pylori In the Gastric Mucosamentioning

confidence: 99%

Helicobacter pylori and Gastric Cancer

Bornschein

Malfertheiner

2014

Dig Dis

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Infection with Helicobacter pylori is established as the major risk factor for gastric cancer development. Damage of the mucosal barrier due to H. pylori-induced inflammation enhances the carcinogenic effect of other risk factors such as salt intake or tobacco smoking. The genetic disposition of both the bacterial strain and the host can increase the potential towards gastric cancer formation. Genetic variance of the bacterial proteins CagA and VacA is associated with a higher gastric cancer risk, as are polymorphisms and epigenetic changes in host gene coding for interleukins (IL1β, IL8), transcription factors (CDX2, RUNX3) and DNA repair enzymes. Application of high-throughput assays for genome-wide assessment of either genetic structural variance or gene expression patterns may lead to a better understanding of the pathobiological background of these processes, including the underlying signaling pathways. Understanding of the stepwise alterations that take place in the transition from chronic atrophic gastritis, via metaplastic changes, to invasive neoplasia is vital to define the ‘point of no return' before which eradication of H. pylori has the potential to prevent gastric cancer. Currently, eradication as preventive strategy is only recommended for high-incidence regions in Asia; large population studies with an adequate follow-up are required to demonstrate the effectiveness of such an approach in Western populations.

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“…5,[32][33][34][35][36][37][38] The specific presentation depends on the virulence features of the bacteria, host characteristics and environmental factors. Many studies have shown that the most virulent genotypes of H. pylori are cagA(+), vacA (+).…”

Section: Clinical Presentationmentioning

confidence: 99%

Clinical differences of Helicobacter pylori infection in children

Iwańczak¹,

Buchner²,

Iwańczak³

2017

Adv Clin Exp Med

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Helicobacter pylori infection is widely spread all over the world. The prevalence of H. pylori infection in the world varies and depends on numerous factors such as age, ethnicity, geographical and socioeconomic status. Humans have been in a symbiotic relationship with this bacterium for thousands of years. However 10-20% of people infected with H. pylori are likely to develop gastroduodenal diseases such as peptic ulcer disease, iron deficiency anemia, gastric mucosal atrophy, metaplasia, dysplasia, MALT lymphoma, or gastric adenocarcinoma. Most of these diseases develop as the infection progresses and they are likely to occur later in life among the elderly. In the following years, the use of modern molecular techniques has led to the discovery of new Helicobacter strains and their genotypic differentiation. Newly discovered Helicobacter microorganisms can colonize human gastrointestinal tract and bile ducts. This article summarizes the distinct features of H. pylori infection in children including its prevalence, clinical manifestation, indications for treatment and recommended schemes of eradication.

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Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells

Cited by 43 publications

References 48 publications

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Helicobacter pylori and Gastric Cancer

Clinical differences of Helicobacter pylori infection in children

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