Helicobacter Pylori, Zinc and Iron in Oxidative Stress-Induced Injury of Gastric Mucosa

Dovhanj, Jasna; Kljaić, Ksenija; Dodig-Ćurković, Katarina; Ćurković, Mario; Volarevic, M.; Marjanović, Ksenija

doi:10.2174/138955709787001767

Cited by 10 publications

(4 citation statements)

References 62 publications

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“…Zinc deficiency may affect the intercellular junctional complexes structure of gastro-intestinal epithelial cells and result in consequently allow a more extensive migration of neutrophils. Depletion of zinc strongly destroys membrane barrier function and integrity, induces an increase in neutrophil accumulation, and starts a positive regulation of chemokines that plays an important role in neutrophil migration and inflammatory development (Dovhanj et al, 2009;Christudoss et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.

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Section: Discussionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Zinc insufficiency has been shown to severely compromise the integrity and function of cell membranes. This can lead to increased accumulation of neutrophils and upregulation of chemokines, which play a crucial role in the migration of neutrophils and the development of inflammation (30,31). Therefore, it is very important that healthy people infected with H. pylori have sufficient Zinc intake to prevent the destruction of H.pylori to the gastric membrane (32)(33)(34)(35)(36).…”

Section: Zincmentioning

confidence: 99%

Nutrition and Helicobacter pylori infection in gastric disease

Selma İrem SÖZEN,

Hafize Kovancı,

Muhammed Said Dalkılıç

et al. 2023

World J. Adv. Res. Rev.

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H. pylori is a highly prevalent bacterial infection among humans. It is considered the major etiological factor in the development of chronic gastritis, peptic ulcers, and stomach cancer. Nutritional therapy is important for the prevention of gastritis, as well as for reducing stomach irritation (irritation) in the treatment of gastritis, and it plays an important role by helping to eradicate or strengthen the stomach wall. Chronic gastritis should be diagnosed before it progresses and causes fatal diseases such as peptic ulcer or cancer, and it should be treated with both a healthy diet and appropriate medications.

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“…Host intracellular iron has been noticed as an important cofactor in induction of NADPHdependent oxidative burst. The changed equilibrium of intracellular iron could influence the course of infection to the enhancement of the pathogen with regard to oxidative stress (Dovhanj et al, 2009). The expression of eight proteins (78 kDa glucose-regulated protein precursor, endoplasmin precursor, aldehyde dehydrogenase 2 and L-lactate dehydrogenase B chain, intracellular chloride channel protein 1, glutathione S-transferase, heat-shock protein 60 and cytokeratin 8) were altered in the H. pylori-infected tissues compared with the non-infected tissues.…”

Section: Helicobacter Pylori-induced Oxidative Stressmentioning

confidence: 99%