Hematological Profile of Normal Pregnant Women in Western India: A Cohort Study in Rural Population of Gujarat

Purohit, Geetanjali; Shah, Trushna; Harsoda, J M

doi:10.9734/bpi/rdmmr/v6/13696d

Cited by 3 publications

(4 citation statements)

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“…It is assumed that elevated leukocyte levels associated with pregnancy at LA are due to the physiological stress led by the state of pregnancy, and an increase in the number of neutrophils is probably a homeostatic answer to apoptosis of the altered neutrophil expressed during pregnancy [ 31 ]. The finding that IL-6 (a pro-inflammatory cytokine) levels were not different between pregnant women at LA and in HA but that their values were unchanged during gestation, suggests that differences in WBC during normal pregnancy are not associated with inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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The objectives of the study were to determine differences in the parameters of red blood cells (RBC), white blood cells (WBC), and platelets at low altitude (LA) and at high altitude (HA) and with the gestation being advanced, and to determine correlations between parameters of RBC and platelets. We also studied the association of RBC and platelets with markers of iron status. In addition, markers of iron status and inflammation were measured and compared at each trimester of gestation in pregnant women at LA and HA. A cross-sectional comparative study was conducted at Lima (150 m above sea level) and Cusco at 3400 m above sea level from May to December 2019. Hematological parameters in pregnant women (233 at LA and 211 at HA) were analyzed using an automated hematology analyzer. Serum ferritin levels, soluble transferrin receptor (sTfR), hepcidin, erythropoietin, testosterone, estradiol, and interleukin-6 (IL6) levels were measured by ELISA. One-way ANOVA supplemented with post hoc test, chi-square test, and Pearson correlation test statistical analyses were performed. p < 0.05 was considered significant. Pregnant woman at HA compared to LA had significantly lower WBC (p < 0.01), associated with higher parameters of the RBC, except for the mean corpuscular volume (MCV) that was no different (p > 0.05). Platelets and mean platelet volume (MPV) were higher (p < 0.01), and platelet distribution width (PDW) was lower at HA than at LA (p < 0.01). A higher value of serum ferritin (p < 0.01), testosterone (p < 0.05), and hepcidin (p < 0.01) was observed at HA, while the concentration of sTfR was lower at HA than at LA (p < 0.01). At LA, neutrophils increased in the third trimester (p < 0.05). RBC parameters decreased with the progress of the gestation, except RDW-CV, which increased. The platelet count decreased and the MPV and PDW were significantly higher in the third trimester. Serum ferritin, hepcidin, and serum testosterone decreased, while sTfR and serum estradiol increased during gestation. At HA, the WBC and red blood cell distribution width- coefficient of variation (RDW-CV), PCT, and serum IL-6 did not change with gestational trimesters. RBC, hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin concentration (MCHC), and platelet count were lower as gestation advanced. MCV, MPV, and PDW increased in the third trimester. Serum ferritin, testosterone, and hepcidin were lower in the third trimester. Serum estradiol, erythropoietin, and sTfR increased as gestation progressed. Direct or inverse correlations were observed between RBC and platelet parameters and LA and HA. A better number of significant correlations were observed at HA. Hb, Hct, and RDW-CV showed a significant correlation with serum ferritin at LA and HA. Of these parameters, RDW-CV and PDW showed an inversely significant association with ferritin (p < 0.05). In conclusion, a different pattern was observed in hematological markers as well as in iron status markers between pregnant women at LA and HA. In pregnant women a significant correlation between several RBC parameters with platelet marker parameters was also observed. Data suggest that pregnant women at HA have adequate iron status during pregnancy as reflected by higher serum ferritin levels, lower sTfR levels, and higher hepcidin values than pregnant women at LA.

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Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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“…During the gestational stages, a decrease in circulation hepcidin levels suggests pregnant iron deficiency it is essential for the preservation of healthy maternal and homeostasis of embryonic iron (45). Additionally, a reduction in serum hepcidin levels Improves maternal iron absorption and placental transfer of dietary ironresulting in an improvement in the newborn iron status (46). It is yet unknown how hepcidin levels are regulated throughout pregnancy.…”

Section: Biochemical Alterations Of the Study Populationmentioning

confidence: 99%

Physiological, hematological and some biochemical alterations during pregnancy

Saleem

Muhammed

Al-Hetty

et al. 2022

ijhs

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The mother's body undergoes several changes in all organ of the bodily systems to stimulate the growth and development of the fetus; hence, the clinical laboratory play an important role in the management of pregnant women. A total number of 90 sample were (60 pregnant and 30 control) from the general women population that were referrals from al-Ramadi of obstetrician – gynecologist hospital in the period November 2021 to June 2022. The result of statistical analysis of the present study showed there were no significantly differences between age of pregnant and control group and the gestation period time the pregnant women was 15 % in 1st trimester of gestation, 35 % in 2nd trimester of gestation and 50 % in 3rd trimester of gestation , in addition complete peripheral blood count examination ( leukocytes , Neutrophils , Lymphocytes ,Erythrocytes , Hemoglobin , Hematocrit , and Platelet) revealed significantly lower rates of pregnancy compared to the control group while (Neutrophil) were revealed significantly increase between pregnant and control group.

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“…The physiological changes of pregnancy, due to the influence of hormones such as oestrogen, progesterone,prolactin, renin, human placenta lactogen also affect haematological indices when compared with the non-pregnant state [1]. The haematological parameters is further influenced by race, geographical location, age, environmental factors and the prevalence of infectious diseases such as malaria [2]. On average, one in four pregnant women in areas of stable transmission in Africa has evidence of malaria infection at the time of delivery based on the estimated prevalence of 26% of placental malaria [3].…”

Section: Introductionmentioning

confidence: 99%

“…In Sub-Saharan Africa, Plasmodium falciparum infection of the placenta remains a major challenge among pregnant women [4] and its prevalence is influenced by maternal age, gravidity, use of malarial prophylaxis, nutrition, host genetics, level of host's immunity, parasite genetics and transmission rates [5]. Maternal anaemia is the commonest consequence of Plasmodium falciparum malarial infection [2]. In Sub-Saharan Africa, Ataide et al [6], in their study reported increase parasitaemia in the placenta is a risk factor for miscarriages in Pregnant women which in most cases may have adverse effect on the foetus.…”

Section: Introductionmentioning

confidence: 99%

Variation in some Haematological Parameters in Patients with Plasmodiasis Attending Antenatal Clinic in Primary Health Care Centre, Ozuoba, Port Harcourt

Echonwere-Uwikor

Chukwuigwe-Igbere

Chukwu

et al. 2022

JAMPS

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Introdction: Haematological parameters are useful in making diagnosis of diseases and also help in the antenatal assessment of women during pregnancy. The physiological changes of pregnancy, due to the influence of hormones such as oestrogen, progesterone also affect haematological indices when compared with the non-pregnant state. Aim: The study investigated haematological indices in pregnant women with plasmodiasis attending antenatal clinics in Primary health care centre Ozuoba, Port Harcourt. Methodology: This was a cross sectional study, which recruited a total of one hundred (100) subjects, of which (40) were non parasitized pregnant women who served as control, while (60) were parasitized pregnant women who served as test. The samples were analyzed for haematological parameters using (Sysmex XP-300), while microscopy was used to investigated for the presence of malaria parasite. Result: Comparing the hematological parameters of the study population at different level of plasmodiasis, showed that WBC, and Neutrophil were significant with p-Value of 0.001 and 0.0089 respectively at P<0.05. The other haematological parameters such as, Red Blood Cell, Haemoglobin, Haematocrit, Mean Cell Volume, Mean Cell Haemoglobin, Mean CellHaemoglobin Concentration, Platelet, Plateletcrit, Neutrophils, lymphocyte, monocyte, eosinophil and basophil showed no statistical significant difference at p<0.05. While comparison of the haematological parameters of the study group according to parity showed that WBC count had statistical significance with a p-Value of 0.0035 at p<0.05. Conclusion: Findings from this study has shown that there was statistical significant difference in the white blood cell count of malaria-parasitized pregnant subject. It was further revealed that there was no statistical significant difference in the other haematological parameters. The reason for the pattern of result obtained is that some of the pregnant women may have been receiving prophylactic antimalarial drugs before their recruitment, this will in turn minimize the impact of malaria infection on some haematological parameters.

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Hematological Profile of Normal Pregnant Women in Western India: A Cohort Study in Rural Population of Gujarat

Cited by 3 publications

References 0 publications

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Physiological, hematological and some biochemical alterations during pregnancy

Variation in some Haematological Parameters in Patients with Plasmodiasis Attending Antenatal Clinic in Primary Health Care Centre, Ozuoba, Port Harcourt

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