Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.

Abstract

The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1-3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

“…The measurement of the zeta potential allows predictions about the storage stability of colloidal dispersion. In general, particle aggregation is less likely to occur for charged particles (high zeta potential) due to electric repulsion (Enomoto et al, 2001). The DSC thermal behavior of the untreated S154 was chosen as reference for the examination of the crystallinity of colloidal SLN matrices.…”

“…N. sativa plant is one of the most extensively studied, both phytochemically and pharmacologically. The extracts of N. sativa seeds have been used by patients to suppress coughs disintegrate renal calculi, retard the carcinogenic process (Worthen et al, 1998;Hosseinzadeh et al, 2007) treat abdominal pain, diarrhea, flatulence and polio (Enomoto et al, 2001), exert choleretic and uricosuric activities, antiinflammatory (Chakravarty, 1993;Houghton et al, 1995) and antioxidant effects (Mansour et al, 2002;Mansour, 2000). Besides, the essential oil was shown to have antihelminthic (Agarwal et al, 1979), antinematodal (Akhtar and Riffat, 1991), antischistosomal (Mahmoud et al, 2002), antimicrobial (Aboul-Ela et al, 1996;Hanafy and Hatem, 1991;Aboul-Ela, 2002) and antiviral (Salem and Hossain, 2000) effects.…”

Cuminum cyminum – A Popular Spice: An Updated Review

“…The aqueous and oil extracts of the black cumin seeds have been shown to possess antioxidant, anti-inflammatory, anticancer, analgesic, antimicrobial activities and applications has in sanitary, cosmetic, agricultural and food industries. Black cumin seeds have been also used by patients to suppress coughs disintegrate renal calculi, retard the carcinogenic process, [25][26] treat abdominal pain, diarrhea, flatulence and polio, 27 exert choleretic and uricosuric activities, carminative, stimulatory and diaphoretic properties, anti-inflammatory 28,29 and antioxidant effects. 30,31 It is also used in the treatment of bronchial asthma and eczema.…”

The Favorable Effect of Style of Zea mays L. on Streptozotocin Induced Diabetic Nephropathy

“…2) We previously reported the effectivity of Chinese crude drugs, marine algae and traditional Turkish folk medicines against these risk factors. [3][4][5][6] In this research we focused on effectivity of the style of Zea mays L. (Gramineae) on diabetic nephropathy. The style of Z. mays is commonly known as corn silk and has been used in folk medicine as a decoction for diuretic treatment in Japan and China.…”