Hematopoietic effect of ginsenoside Rg3 in ICR mouse primary cultures and its application to a biological response modifier

Joo, Seong-Soo; Won, Tae Joon; Kim, M.S.; Lee, D.I.

doi:10.1016/j.fitote.2004.02.008

Cited by 20 publications

(13 citation statements)

References 10 publications

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“…Ginsenoside Rg3 could regulate the proliferation of the spleen and bone marrow cells, and enhance the colony formation of hematopoietic progenitor cells (Joo et al, 2004). The current study revealed that ginsenosides displayed a stimulatory action on type A spermatogonial proliferation by colony formation.…”

Section: Discussionmentioning

confidence: 52%

Ginsenosides stimulated the proliferation of mouse spermatogonia involving activation of protein kinase C

Zhang

Wang

Zhang

2009

J. Zhejiang Univ. Sci. B

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Abstract:The effect of ginsenosides on proliferation of type A spermatogonia was investigated in 7-day-old mice. Spermatogonia were characterized by c-kit expression and cell proliferation was assessed by immunocytochemical demonstration of proliferating cell nuclear antigen (PCNA). After 72-h culture, Sertoli cells formed a confluent monolayer to which numerous spermatogonial colonies attached. Spermatogonia were positive for c-kit staining and showed high proliferating activity by PCNA expression. Ginsenosides (1.0~10 μg/ml) significantly stimulated proliferation of spermatogonia. Activation of protein kinase C (PKC) elicited proliferation of spermatogonia at 10 −8 to 10 −7 mol/L and the PKC inhibitor H 7 inhibited this effect. Likewise, ginsenosides-stimulated spermatogonial proliferation was suppressed by combined treatment of H 7 . These results indicate that the proliferating effect of ginsenosides on mouse type A spermatogonia might be mediated by a mechanism involving the PKC signal transduction pathway.

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Section: Discussionmentioning

confidence: 52%

Ginsenosides stimulated the proliferation of mouse spermatogonia involving activation of protein kinase C

Zhang

Wang

Zhang

2009

J. Zhejiang Univ. Sci. B

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“…1). 11) A concentrated stock solution (10 mg/ml) of Rg3 was prepared by dissolving in 10% dimethylsulfoxide (DMSO, Sigma, MO, U.S.A.) and was kept at 4°C until use. The stock solution was further diluted in culture media at a 1 : 10 ratio for cell treatments.…”

Section: Methodsmentioning

confidence: 99%

Prevention of Inflammation-Mediated Neurotoxicity by Rg3 and Its Role in Microglial Activation

Joo

Yoo

Ahn

et al. 2008

Biological & Pharmaceutical Bulletin

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“…For example, nine repeated cycles of steaming, commonly used for Rehmannia root preparation, have been applied to ginseng to make black ginseng, which can increased ginsenoside Rg 3 in red ginseng. Ginsenoside Rg 3 is known for its neuroprotective, anti-anemic, and analgesic effects [7,8] and is being massproduced in China, where has been successfully commercialized as anti-cancer treatment agent [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

Lee¹,

Yun²,

Liu³

et al. 2010

Journal of Ginseng Research

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:This study compared the effects of black, white, and red ginseng extracts (WGE, RGE, BGE, 200 mg/kg, p.o.) on learning and memory deficits associated with scopolamine treatment (SCOP, 2 mg/kg, i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. Ginseng significantly reversed SCOP-induced memory impairment in the passiveavoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased acetylcholinesterase (AChE) activity produced by SCOP was significantly inhibited by WGE and RGE (p<0.001). SCOP administration had no effect on choline acetyltransferase (ChAT) activity, but RGE and BGE significantly increased ChAT activity (p<0.05). SCOP administration increased oxidative damage in the brain. Treatment of amnesic mice with ginseng extracts decreased malondialdehyde (MDA) levels and restored superoxide dismutase (SOD) and catalase (CAT) activity to control levels. These results suggest that black ginseng enhances cognitive activity by regulation of cholinergic enzymes and antioxidant systems.

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Hematopoietic effect of ginsenoside Rg3 in ICR mouse primary cultures and its application to a biological response modifier

Cited by 20 publications

References 10 publications

Ginsenosides stimulated the proliferation of mouse spermatogonia involving activation of protein kinase C

Ginsenosides stimulated the proliferation of mouse spermatogonia involving activation of protein kinase C

Prevention of Inflammation-Mediated Neurotoxicity by Rg3 and Its Role in Microglial Activation

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

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