Hemodynamic Parameters Change Earlier Than Tissue Oxygen Tension in Hemorrhage

Pestel, G.; Fukui, Kimiko; Kimberger, Oliver; Hager, Helmut; Kurz, Andrea; Hiltebrand, Luzius B.

doi:10.1016/j.jss.2008.11.002

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…During a normative donation of 400 ml of whole blood, about 10% of the total blood volume is taken from the human circulation within several minutes, Most blood donors generally can tolerate a blood loss of such magnitude even in the elderly (Gandini et al 1999;Janetzko et al 1998Janetzko et al , 2001, however, about 0.15% of donors experience severe adverse reaction such as syncope, with loss of consciousness due to decreased cerebral perfusion. Many studies (Vespa et al 1997(Vespa et al , 2005Janetzko et al 2001;Zöllei et al 2004;Pestel et al 2006;Pestel et al 2010) regarding physiological responses to hemorrhage have been performed in a variety of species and with many different approaches. Zöllei et al (2004) studied autonomic responses to blood donation in 48 healthy volunteers and concluded that the 350-400 ml acute volume loss in 5 min lead to sympathetic activation, which was followed by increased systolic, diastolic and mean blood pressure.…”

Section: Introductionmentioning

confidence: 99%

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Zhang

Zhang²,

Yang

et al. 2011

Brain Topogr

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The aim of this study was to investigate the effect of 400 ml whole blood donation on the human electroencephalogram (EEG) and hematology, not earlier reported in the literature. EEG activity was recorded from ten male blood donors (experiment group) before, during and after blood donation (i.e., 400 ml whole blood withdrawal). EEG topography and regional spectral field powers analyses were carried out via fast Fourier transformation. The venous hemoglobin (Hb) concentration was measured with a hematology analyzer. In the control investigation, 12 male age-matched volunteers (control group) were kept in semi-sitting position for the duration of a blood donation without actually vena puncture. The volunteers had no prior experiences of blood donation. Within the experiment group, post-donation Hb concentration decreased by 3.7% compared with the pre-donation Hb values (P < 0.01). Before blood donation, Hb concentration in control group was significantly higher compared to the experiment group (P < 0.05). For the experiment group, the field power of alpha-1 (7.5-9.5 Hz) EEG during blood withdrawal was significantly lower compared to that after blood withdrawal (P < 0.05). In contrast for the control group, all seven bands of regional spectral field powers showed no significantly discrepancies in the three periods. Blood donation attenuates the alpha-1 at the parietal-frontal area on human EEG-DMN transiently with no lasting effect at post-donation period. The blood donation-related effects on brain function may be of little consequence due to slight hemodynamic change and the results may facilitate the opinion that blood donation is a safe process and that should not discourage volunteers.

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Section: Introductionmentioning

confidence: 99%

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Zhang

Zhang²,

Yang

et al. 2011

Brain Topogr

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“…However, one group reported contrary findings in a pig model, where changes in systemic haemodynamic variables were more sensitive than tissue oxygen tension measured with Clark-type electrodes in the jejunal and colonic wall, liver, and s.c. tissue (using a tonometer) during haemorrhage. 32 Here, the tissue oxygen tensions did not decrease until 20-40% of estimated blood volume had been withdrawn, which is a rather surprising finding. The reasons for this disparity are unclear but could be methodological.…”

Section: Tissue Oxygen Tension Monitoring In Shock States and Other Rmentioning

confidence: 65%

Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

Santis

Singer

2015

British Journal of Anaesthesia

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Tissue oxygen tension is the partial pressure of oxygen within the interstitial space of an organ bed. As it represents the balance between local oxygen delivery and consumption at any given time, it offers a ready monitoring capability to assess the adequacy of tissue perfusion relative to local demands. This review covers the various methodologies used to measure tissue oxygen tension, describes the underlying physiological and pathophysiological principles, and summarizes human and laboratory data published to date.

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“…Accurate estimation of intraoperative blood loss is an important component of circulatory competency assessment and management (4,5). Estimating blood loss volume, together with systemic indicators such as digital pulse pressure (dPP) and MAP, provides important information for making appropriate fluid therapy decisions including whole blood transfusion (6,7).…”

Section: Introductionmentioning

confidence: 99%

Blood Loss Estimation in Small Animals and Assessment of a Pictorial Tool to Improve Accuracy in a Global Population of Veterinary Anesthesia Staff

Cumming

Martínez-Taboada

2020

Front. Vet. Sci.

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Visual estimation of blood loss is the most common form of evaluating intraoperative hemorrhage, and is also the most inaccurate. This study investigated the visual estimation accuracy of a global population of anesthesia staff and students as an initial estimation and also with the assistance of a pictorial guide. A voluntary, two-part, online, anonymous survey was distributed to members of two email databases with an interest in anesthesia, including students, nurses, interns, residents, general practitioners, and specialists. The survey consisted of visual and brief descriptive depictions of blood loss scenarios involving small animals, principally including images of common surgical items and receptacles containing a blood-like substance. Each participant estimated the blood volume (in mL) for each scenario twice, initially (Pre-Guide [PGD]) and then with the aid of a pictorial guide (With-Guide [WGD]). The pictorial guide used similar images labeled with corresponding volumes. Data was analyzed for normality with the Shapiro-Wilks test, corrected to absolute error and compared for statistical significance using the Wilcoxon signed-ranks test or the Kruskal-Wallis test as appropriate. The overall raw PGD phase median estimation error was−27 mL (range −99 to 248 mL). The PGD raw median error increased with scenario complexity. There were no differences between role, gender, experience, or country of origin. The overall median raw estimation error for the WGD phase was 13 mL (range −80 ml to 143 mL) (p = 0.0128). Visual blood loss estimation is inaccurate amongst veterinary anesthetists and associated staff, showing decreasing accuracy with increasing complexity. A pictorial guide improves the accuracy generally, and specifically for more complex scenarios which are likely to reflect the clinical situation.

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Hemodynamic Parameters Change Earlier Than Tissue Oxygen Tension in Hemorrhage

Cited by 14 publications

References 24 publications

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

Blood Loss Estimation in Small Animals and Assessment of a Pictorial Tool to Improve Accuracy in a Global Population of Veterinary Anesthesia Staff

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