Hemoglobinopatías diagnosticadas en el área sanitaria del Hospital Universitario Nuestra Señora de Candelaria de Santa Cruz de Tenerife durante un año

Flórez, Salazar; Hernández, Lilia Mestas

doi:10.4321/s0212-71992008000200003

Cited by 2 publications

(1 citation statement)

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“…This value is three times higher than that recently reported by Modell et al with a estimated percentage of pregnant woman carriers for haemoglobinopathy of 0.34% 28. The results of a very recent haemoglobinopathy study, also performed in the Canary Islands by De Las Heras et al ,29 reported that a total of 198 haemoglobinopathies were found in an adult population, with 125 of them corresponding to structural variants. In three cases SCD was identified, and in 70 cases AS was identified.…”

Section: Scd In Spainmentioning

confidence: 58%

Neonatal haemoglobinopathy screening in Spain

Pereira

Corrons²

2008

J Clin Pathol

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The prevalence of variant haemoglobins in Spain is increasing as a result of recent African immigration. Of the 19 regions of Spain, 13 have more than 1% of residents of African origin or ethnicity. Haemoglobinopathy prevalence is heterogeneous. Some cases of sickle cell disease (SCD) and sickle cell trait have been found in autochthonous individuals, but this is very rare. Most of the studies of SCD prevalence in Spain are incomplete or focused on a few geographical regions. When screening has been carried out regardless of ethnic origin, overall haemoglobinopathy prevalence has varied from 0.14% to 0.94% and the estimated prevalence of SCD has varied from 0.001 (in Extremadura) to 0.03 (in Aragón). A registry for SCD maintained by the Spanish Society of Paediatric Haematology shows that in the last 4 years the prevalence of SCD has increased threefold. Only two Spanish Communities (Extremadura and Madrid) are running an official neonatal screening programme for SCD. Other Spanish Communities have finished local pilot studies and are expected to establish neonatal screening programmes shortly. Catalonia, the Spanish community with the highest African immigration flow and SCD genetic impact, has not yet established an official programme for SCD neonatal screening; screening currently depends on individual hospital policies and is restricted to at-risk ethnic groups. Studies performed so far suggest that universal screening should be recommended for regions with a high annual birth rate and SCD prevalence (Catalonia and Madrid, for example), with a targeted policy being restricted to regions with low annual birth rate and SCD prevalence.

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Section: Scd In Spainmentioning

confidence: 58%