Hemolysis by surfactants — A review

Manaargadoo-Catin, Magalie; Ali-Cherif, Anaïs; Pougnas, Jean-Luc; Perrin, Catherine

doi:10.1016/j.cis.2015.10.011

Cited by 146 publications

(125 citation statements)

References 113 publications

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“…One report discussed the detailed mechanism for the changes in the RBC membrane and subsequent hemolysis by surfactants [4]. The first step in the surfactant effect on the cell or tissue is permeation or partition of compounds into the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro

Mineo¹

2017

Biochem Pharmacol

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Section: Discussionmentioning

confidence: 99%

“…Although there is some debate over whether monocarboxylic acids possessing a small number of hydrocarbons (<10) should be categorized as surfactant [4] or not [5], they could be recognized as a kind of surfactant-like substance due to their chemical structure and amphiphilic characteristic.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro

Mineo¹

2017

Biochem Pharmacol

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“…These cells' contact with nonbiological objects may significantly affect their functions [18,19]. Nanomaterial interaction with these cells has different effects depending on their intrinsic characteristics.…”

Section: Interaction Of Nanomaterials With Red Cellsmentioning

confidence: 99%

Interaction of Nanoparticles with Blood Components and Associated Pathophysiological Effects

Cruz¹,

Rodríguez-Fragoso²,

JorgeReyes-Esparza³

et al. 2018

Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications

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Nanotechnology currently plays a pivotal role in several fields and has enabled substantial advances in a relatively short time. In biomedicine, nanomaterials can be potentially employed as a tool for early diagnosis and an innovative mode of drug delivery. Novel nanomaterials are currently widely manipulated without a full assessment of their potential health risks. It is commonly thought that nanomaterials' first contact with the organism is through the different components of the immune system. However, if the entry route is intravenous, the first contact will be with the blood's components (erythrocytes, platelets, white cells, plasma and complement proteins). The presence of nanomaterials within a dynamic environment such as the bloodstream can produce potential harmful effects following interaction with several blood components. The design of innovative strategies leading to the development of more hemocompatible nanomaterials is also necessary.

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“…The effects of Micafungin are reminiscent to the hemolytic effects of surfactant [97]. It is actually the purpose of eryptosis to clear defective erythrocytes from circulating blood prior to hemolysis [42].…”

Section: +mentioning

confidence: 99%

Micafungin-Induced Suicidal Erythrocyte Death

Peter

Bissinger

Signoretto

et al. 2016

Cell Physiol Biochem

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Background/Aims: The antifungal drug Micafungin is used for the treatment of diverse fungal infections including candidiasis and aspergillosis. Side effects of Micafungin treatment include microangiopathic hemolytic anemia and thrombocytopenia with microvascular thrombosis. The development of thrombosis may be fostered by stimulation of eryptosis, the suicidal death of erythrocytes characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca²⁺ activity ([Ca²⁺]_i), oxidative stress, ceramide, activated protein kinase C (PKC), casein kinase 1α or p38 kinase and activated caspases. The present study explored, whether Micafungin induces eryptosis. Methods: Flow cytometry was employed to estimate phosphatidylserine abundance at the erythrocyte surface from annexin-V-binding, cell volume from forward scatter, [Ca²⁺]_i from Fluo3-fluorescence, abundance of reactive oxygen species (ROS) from DCFDA dependent fluorescence, and ceramide abundance at the erythrocyte surface utilizing specific antibodies. Hemolysis was quantified by measuring haemoglobin concentration in the supernatant. Results: A 48 hours exposure of human erythrocytes to Micafungin (10 - 25 µg/ml) significantly increased hemolysis and the percentage of annexin-V-binding cells, and significantly decreased forward scatter. Micafungin (25 µg/ml) did not significantly modify Fluo3-fluorescence, DCFDA fluorescence, or ceramide abundance. The effect of Micafungin on annexin-V-binding was not significantly modified by removal of extracellular Ca²⁺, by PKC inhibitor staurosporine (1 µM), p38 kinase inhibitor SB203580 (2 µM), casein kinase 1α inhibitor D4476 (10 µM) or pancaspase inhibitor zVAD (10 µM). Conclusions: Micafungin triggers hemolysis and eryptosis with cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane.

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Hemolysis by surfactants — A review

Cited by 146 publications

References 113 publications

Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro

Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro

Interaction of Nanoparticles with Blood Components and Associated Pathophysiological Effects

Micafungin-Induced Suicidal Erythrocyte Death

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