Hemolysis index to detect degree of hydroxocobalamin interference with common laboratory tests

Fueyo, Laura; Robles, Juan; Aguilar, I Benavente; Yáñez, Aina M.; Socias, Magdalena; M, Parera

doi:10.1002/jcla.22089

Cited by 11 publications

(2 citation statements)

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“…The red discoloration of body fluids after OHCob administration makes laboratory evaluation by spectrophotometric techniques erroneous. 16 Of greatest concern is the accuracy of COHb concentrations. 17 In a study using rabbit models by Lee et al, 17 OHCob administration was shown to falsely increase COHb concentrations.…”

Section: Effect Of Hydroxocobalamin On Laboratory Evaluationmentioning

confidence: 99%

“…Of particular clinical importance, a falsely increased lactate level was seen after true lactate levels were found to be below 4.8 mmol/L (but not greater) using spectrophotometric or electrochemical detection. 21 This increase in the false-positive assessment of the degree of toxicity could lead unnecessary escalation of care.…”

Section: Examining the Effects Of Ohcob Onmentioning

confidence: 99%

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Carbon Monoxide: The Other Silent Killer

Cumpston¹,

Rose²

2017

Emerg Med

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A 50-year-old woman was pulled from the window of a burning building and found to be in cardiac arrest with pulseless electrical activity. Standard advanced cardiac life-support was started, and infusion of intra-osseous hydroxocobalamin (OHCob) was administered at the time of intubation because of the concern for cyanide (CN) gas exposure during smoke inhalation. Return of spontaneous circulation occurred before arrival at the hospital.Upon presentation to the ED, the patient's vital signs were: initial blood pressure (BP), 92/47 mm Hg; heart rate (HR), 112 beats/min; respiratory rate (RR), 31 breaths/min; and temperature (T), 99.7°F.Following intubation, the patient's oxygen saturation (SaO 2 ) on pulse oximetry (POX) was 93%, and her fraction of inspired oxygen (FiO 2 ) was 100%.On physical examination, the patient's face was covered with soot. The lung sounds were equal and clear to auscultation bilaterally. The neurological examination was significant for a Glasgow Coma Scale of 3, without administered sedation, and there were no signs of dermal burns. Initial arterial blood gas (ABG) results were: pH, 7.06; carbon dioxide partial pressure (PCO 2 ), 58 mm Hg; partial pressure of oxygen (PO 2 ), 152 mm Hg; bicarbonate (HCO 3 ), 17 mm Hg; SaO 2 , 98% (after intubation); FiO 2 , 100%; carboxyhemoglobin (COHb), 30%; and lactate, 14 mmol/L.

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Section: Effect Of Hydroxocobalamin On Laboratory Evaluationmentioning

confidence: 99%

Section: Examining the Effects Of Ohcob Onmentioning

confidence: 99%