Hemolytic Disease in Newborn Dogs

Young, Lawrence E.; Christian, Richard M.; Ervin, Donald M.; Davis, R. Wendell; O’Brien, William A.; Swisher, Scott N.; Yuile, Charles L.

doi:10.1097/00006254-195202000-00019

Cited by 7 publications

(11 citation statements)

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“…Nevertheless, care must be taken during pretransfusion procedures in canine females, since neonatal isoerythrolysis occurs in DEA 1-positive pups when DEA 1-negative bitches immunized with IV injections of DEA 1-positive RBC and mated with DEA 1-positive sires. The fact was not observed on DEA 4-positive puppies born from DEA 4-negative bitches immunized against DEA 4 by blood transfusions (Young et al 1951, Swisher & Young 1961.…”

Section: Resultsmentioning

confidence: 84%

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

et al. 2011

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RESUMO.-[Frequências dos tipos sanguíneos do sistema DEA em uma população de cães de raça doadores de sangue em Porto Alegre, RS.] O estudo da imunohematologia canina é muito importante para a medicina veterinária transfusional. O objetivo deste estudo foi determinar as frequências dos tipos sanguíneos do sistema DEA em uma população de cães de raça que fazem parte de um programa de cães doadores de sangue em Porto Alegre, RS, Brasil. Cem cães saudáveis de raça pura foram selecionados, vinte de cada raça (Dogue Alemão, Rottweiler, Golden Retriever, Pastor Alemão e Dogo Argentino). Amostras de sangue foram coletadas em tubos contendo ACD-A e o teste de hemaglutinação em tubo de ensaio da MSU (MI, EUA) foi utilizado para determinar os tipos sanguíneos. A população estudada apresentou frequências gerais de 61% para DEA 1.1, 22% para DEA 1.2, 7% para DEA 3, 100% para DEA 4, 9% para DEA 5 and 16% para DEA 7. Uma associação significativa foi encontrada entre as raças e certas combinações de tipos sanguíneos nesta população. Os resultados estão de acordo com a literatura, visto que a maioria da população canina estudada foi positiva para DEA 1. The study of canine immunohematology is very important for veterinary transfusion medicine. The objective of this study was to determine the DEA blood type frequencies in a purebred canine blood donor population from Porto Alegre, RS, Brazil. One hundred clinically healthy purebred dogs were chosen, 20 dogs from each breed (Great Dane, Rottweiler, Golden Retriever, German Shepherd and Argentine Dogo). Blood samples were taken in ACD-A tubes and the MSU hemagglutination tube test (MI, USA) was used to determine the blood types. The studied population presented general frequencies of 61% for DEA 1.1, 22% for DEA 1.2, 7% for DEA 3, 100% for DEA 4, 9% for DEA 5 and 16% for DEA 7. A significant association was found between breeds and certain combinations of blood types in this population. The results are in agreement with the literature since most part of the canine population studied was positive for DEA 1.1, the most antigenic blood type in dogs. Differences were found among the studied breeds and those should be considered when selecting a blood donor. The knowledge of blood types frequencies and their combinations in different canine populations, including different breeds, is important because it shows the particularities of each group, helps to keep a data bank of local frequencies and minimizes the risks of transfusion reactions.

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Section: Resultsmentioning

confidence: 84%

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

et al. 2011

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“…This concept has gained considerable support by the demonstration of specificities of certain of these "antibodies" in acquired hemolytic anemia (41,42). Attractive as this hypothesis is the possibility of the production of abnormal globulins capable of attachment to erythrocytes by non-antigenic pathways cannot be ignored (21,22 (43)(44)(45) on the production of a positive direct and indirect Coombs test in the dog by infusing incompatible blood and in canine hemolytic disease of the newborn in which "incomplete antibodies" were implicated as the causative factor. Chute and Sommers (46) observed a positive indirect Coombs test in parabiotic disease of the rat.…”

Section: Discussionmentioning

confidence: 99%

Positive Direct Coombs Test Induced by Phenylhydrazine1

Muirhead¹,

Groves²,

Bryan³

1954

J. Clin. Invest.

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“…7 If a female dog has received a mismatched RBC transfusion prior to whelping, alloantibodies in the colostrum might possibly cause alloimmune hemolytic anemia (neonatal isoerythrolysis) in neonatal puppies. 4,10,18 Blood types other than DEA 1.1 seem to be less antigenic. However, severe hemolytic transfusion reactions have been reported in response to DEA 4 and to an unidentified common RBC membrane antigen.…”

Section: Introductionmentioning

confidence: 95%

Clinical evaluation of the QuickVet®/RapidVet® canine dog erythrocyte antigen 1.1 blood-typing test

2012

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In transfusion medicine, blood typing is an integral part of pretransfusion testing. The objective of the current study was the clinical evaluation of an automated canine cartridge dog erythrocyte antigen (DEA) 1.1 blood-typing method (QuickVet/RapidVet) and comparison of the results with a gel column-based method (ID-Gel Test Canine DEA 1.1). Ethylenediamine tetra-acetic acid-anticoagulated blood samples from 11 healthy and 85 sick dogs were available for typing. Before blood typing, all samples were tested for agglutination and hemolysis. All samples were tested once or multiple times with both methods according to the manufacturer's guidelines. With the gel method, 53 dogs tested DEA 1.1 positive and 42 dogs DEA 1.1 negative; blood typing was not possible due to erythrocyte autoagglutination in 1 dog. With the cartridge test, 53 samples tested DEA 1.1 positive, 34 samples tested DEA 1.1 negative, and 6 results were inconclusive (3 samples were not included due to autoagglutination or severe hemolysis). Without taking the inconclusive samples into account, the agreement between both methods was 96.5%. The sensitivity and specificity for samples that were definitively typed by both methods were 100% and 91.9%, respectively. The cartridge test was suitable for in-clinic canine DEA 1.1 blood typing, although some discrepancies compared to the gel method existed. The cartridge test is software-directed, is easy to use, and does not require user interpretation, but preanalytical guidelines (sample evaluation for agglutination and hemolysis) have to be followed. For inconclusive results, an alternate blood-typing method should be performed.

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Hemolytic Disease in Newborn Dogs

Cited by 7 publications

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Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

Positive Direct Coombs Test Induced by Phenylhydrazine1

Clinical evaluation of the QuickVet®/RapidVet® canine dog erythrocyte antigen 1.1 blood-typing test

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