Hemorheology and heart rate variability in patients with diabetes mellitus type 2

Velcheva, Irena; Damianov, Petar; Mantarova, Stefka; Antonova, Nadia

doi:10.3233/ch-2011-1500

Cited by 13 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study focused on changes in hemorheology and hemodynamics, which are indicators of early changes in vascular structure and function. Hematocrit value and plasma viscosity have been shown to correlate with heart rate variability in patients with T2DM ( 37 ). The erythrocyte sedimentation rate has been shown to be a predictor of coronary heart disease and heart failure ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Chinese herbal medicine Shenqi compound for early intervention in patients at high cardiovascular risk of type 2 diabetes mellitus: the protocol of a multicenter, randomized, double-blind, placebo-controlled trial

Leng,

Zhang,

Yao

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

IntroductionReducing multiple cardiovascular risk factors is a key link and a challenging clinical problem to reduce the risk of cardiovascular complications and death in patients with diabetes. Currently, there is a lack of clinical studies on patients with diabetes combined with multiple risk factors. Traditional Chinese medicine is believed to have therapeutic effects that contribute to the comprehensive control of multiple cardiovascular factors. This study aims to provide evidence for the efficacy and safety of Shenqi compound (SQC) for early intervention in diabetic patients at high cardiovascular risk.Methods and analysisThis study is a multicenter, randomized, double-blind, placebo-controlled trial. A total of 120 diabetic patients with high cardiovascular risk were enrolled in five research centers. After a 2-week run-in period, the intervention group received basic treatment and SQC granules, and the control group received basic treatment and placebo granules for a total of 24 weeks, with a 24-week follow-up. The endpoint outcomes are major adverse cardiovascular events and renal-related and peripheral vascular disease events. The primary efficacy outcome is carotid intima-media thickness, and the secondary efficacy outcomes are carotid shear stress, indicators of glucose and lipid metabolism, pancreatic islets function, hemorheology, traditional Chinese medicine syndrome score, and quality of life scale. Safety indicators and adverse events were used to assess the safety of SQC.DiscussionThis study comprehensively evaluated the efficacy and safety of SQC for early intervention in diabetic patients at high cardiovascular risk from the aspects of overall metabolic level, structure, and function of blood vessels, quality of life, and long-term follow-up of endpoint events, providing evidence-based evidence for the short-term efficacy and long-term benefits of early treatment to reduce the risk of diabetic cardiovascular complications.Trial Registration: This trial is registered in the Chinese Clinical Trial Registry on March 9, 2023, https://www.chictr.org.cn/showproj.html?proj=192803 (No. ChiCTR2300069219).

show abstract

Section: Discussionmentioning

confidence: 99%

Chinese herbal medicine Shenqi compound for early intervention in patients at high cardiovascular risk of type 2 diabetes mellitus: the protocol of a multicenter, randomized, double-blind, placebo-controlled trial

Leng,

Zhang,

Yao

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Whole blood viscosity (Forconi et al 2009;Salazar et al 2011) and plasma viscosity (Kiesewetter et al 1986;Koenig et al 1992;Sweeetnam et al 1996;Lowe et al 2000) play an important role in various cardiovascular diseases (Coull et al 1991;Shi et al 1996;Herrick 2005;Velcheva et al 2011) as well as a key role in hyperviscosity syndrome (Stone et al 2012) caused, for instance, by monoclonal gammopathy (Waldenström's disease) (Gertz 2012), multiple myeloma (Park et al 2005), polycythemia (Ickenstein et al 1999), leukemia with blast crises (Dearth et al 1978) and polycythemia in the newborn infant (Mimouni et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Determination of whole blood and plasma viscosity by means of flow curve analysis

Ruef¹,

Gehm²,

Gehm³

et al. 2014

gpb

View full text Add to dashboard Cite

The LS300 viscometer permits automated measurements of viscosity at several shear rates of non-Newtonian fluids. We determined whole blood and plasma viscosity, aggregation, red blood cell deformability, and hematocrit of 66 healthy adults. The effects of the anticoagulants EDTA, heparin and citrate, and of centrifugation on blood viscosity (n=12) and red blood cell geometry (n=5) were investigated. With regard to the whole blood viscosity of adults, the best agreement was obtained by Casson's calculation compared to the methods of Ostwald, Bingham and Newton. The approximated flow curve of plasma showed only marginal differences between the method of Newton and Ostwald, whereas the latter gave the best quality of approximation. Centrifugation and the anticoagulants had a significant impact on whole blood viscosity and yield shear stress, whereas erythrocyte geometry remained unaffected. By linear regression of hematocrit with viscosity and yield shear stress, its impact on blood viscosity could be calculated in a hematocrit range of 0.32-0.50. Determination of whole blood viscosity should be performed in a standardized manner at several shear rates and without centrifugation of the blood samples.

show abstract

“…One potential mechanism for this observation is that arctiin, after transformation into arctigenin, can suppress NF-κB activation and nuclear translocation, which results in a decreased production of pro-inflammatory cytokines [24]. A previous study [25] has indicated that the changes in whole blood viscosity and fibrinogen are the predominant haemorheological variables that contribute to the microcirculatory disturbances in patients with type 2 diabetes. After 16 weeks of arctiin treatment, some viscosity factors, such as the blood viscosity, reduced viscosity of whole blood, and EAI, were not significantly altered; however, the serum glucose concentration was decreased significantly when compared with week 0.…”

Section: Discussionmentioning

confidence: 99%

Effects of Arctiin on Streptozotocin-Induced Diabetic Retinopathy in Sprague-Dawley Rats

Lü

Zhou

et al. 2012

Planta Med

View full text Add to dashboard Cite

Diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L., has been reported to have antidiabetic activity. In this study, we investigated the effect of arctiin on the serum glucose and HBA1c levels, the blood viscosity, and VEGF expression in the retinal tissues of rats with diabetic retinopathy. We first extracted arctiin from Fructus Arctii and then investigated its chemopreventive effect on streptozotocin-induced diabetic retinopathy in male Sprague-Dawley rats. After the induction of diabetes using streptozotocin (30 mg/kg, i. p.), the rats were randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na. Twenty nondiabetic sham-treated rats were treated with 0.5 % CMC-Na. The occurrence of diabetic retinopathy did not differ dramatically among the groups. However, at week 16, the glycosylated haemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin. In addition, treatment with arctiin ameliorated retinal oedema, detachment of the retina, and VEGF expression in the retina, as detected using histological and immunochemical examinations. Finally, arctiin increased the viability of retinal microvascular endothelial cells in vitro. Together, these findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy.

show abstract

Hemorheology and heart rate variability in patients with diabetes mellitus type 2

Cited by 13 publications

References 9 publications

Chinese herbal medicine Shenqi compound for early intervention in patients at high cardiovascular risk of type 2 diabetes mellitus: the protocol of a multicenter, randomized, double-blind, placebo-controlled trial

Chinese herbal medicine Shenqi compound for early intervention in patients at high cardiovascular risk of type 2 diabetes mellitus: the protocol of a multicenter, randomized, double-blind, placebo-controlled trial

Determination of whole blood and plasma viscosity by means of flow curve analysis

Effects of Arctiin on Streptozotocin-Induced Diabetic Retinopathy in Sprague-Dawley Rats

Contact Info

Product

Resources

About