Hemostasis in Epileptic Seizures

Abstract

Convulsive seizures can be accompanied by serious changes in the body. The purpose of this study is to investigate the platelet aggregation using the Born method and the hemolysate aggregation test, coagulation hemostasis (plasma recalcification time, prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time, antithrombin III, fibrinogen, beta‐naphthol test, soluble fibrin monomer complex (SFMK), euglobulin clot lysis time (ECLT) and histological changes of the brain in 20 rats after an epileptic seizure caused by parenteral administration of Nikethamide. All animal experimentation protocols were approved by the UMSA Animal Ethical Committee. Immediately after the convulsive seizure the platelet count, the height of aggregatogram and index of platelet aggregation have been reduced. Shortening of the prothrombin and thrombin time in intact fibrinogen concentration, decreasing of SFMC without changing of ECLT was revealed. Blockade of microcirculatory, injury of the vascular wall, perivascular changes (edema, hemorrhage) were observed in the brain. These results suggest that we have identified laboratory signs of disseminated intravascular coagulation (DIC) (hypercoagulation phenomena, thrombocytopenia, and thrombocytopathia), which were confirmed by morphological features. These data can be used in the management of patients with seizures.