2010
DOI: 10.1002/chir.20873
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Heparin‐induced circular dichroism of an achiral, bicyclic species

Abstract: Antimalarial drugs have shown potential in suppressing the role of glycosaminoglycans (GAGs) in the pathology of prion protein conformational disorders (e.g. "Mad Cow" disease) by competing for sites of electrostatic interaction. In this study, circular dichroism (CD) and UV/Visible (UV/Vis) absorption spectroscopy techniques were used to investigate the interactions between N-methyl-N'-(7-chloro-4-quinolyl)-1,3-diaminopropane (QD), an achiral, bicyclic compound similar to previously investigated antimalarial … Show more

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Cited by 9 publications
(1 citation statement)
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“…Induced circular dichroism (CD) spectroscopy was used to examine the interactions between the pyrene fluorophore of the peptide and heparin. Achiral chromophores, such as pyrene and anthracene, displayed induced CD upon binding to the biomolecules with chiral centers, such as DNA, cyclodextrin, and heparin. On the other hand, the induced CD was observed by interactions between the peptides and achiral chromophores. Surprisingly, 2 showed significant induced CD even in the absence of heparin in 100% aqueous solution and mixed aqueous–organic solvent systems (Figure ).…”
Section: Resultsmentioning
confidence: 99%
“…Induced circular dichroism (CD) spectroscopy was used to examine the interactions between the pyrene fluorophore of the peptide and heparin. Achiral chromophores, such as pyrene and anthracene, displayed induced CD upon binding to the biomolecules with chiral centers, such as DNA, cyclodextrin, and heparin. On the other hand, the induced CD was observed by interactions between the peptides and achiral chromophores. Surprisingly, 2 showed significant induced CD even in the absence of heparin in 100% aqueous solution and mixed aqueous–organic solvent systems (Figure ).…”
Section: Resultsmentioning
confidence: 99%