Heparin-Induced Fever: A Case Report and Literature Review

Laun, Jake; Laun, Katie; Farooqi, Adeel; Smith, David J.

doi:10.1093/jbcr/irz064

Cited by 11 publications

(16 citation statements)

References 7 publications

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“…In these patients became afebrile within 24 hours and 8 hours respectively. 9 Our case demonstrates what is most likely a heparin-induced fever in a neurologically ill patient after ruling out the other possible etiologies. To the best of our knowledge, this is the first reported case in an NICU setup.…”

Section: Discussionmentioning

confidence: 72%

“…Drugs that have been implicated in causing fevers include various anticonvulsants, allopurinol, and certain antibiotics with nitrofurantoin, minocycline, and sulfonamides being the most common. 7 Heparin has been documented as causing drug-induced fever (DIF) with only two previously reported cases by Forni and Murray and Laun et al 8,9 Case Description A 32-year-old female with Guillain-Barré syndrome on ventilator had an episode of bradycardia with asystole on day 2 of NICU admission. Return of spontaneous circulation was achieved in less than 5 minutes, and neurological examination after 72 hours showed decline in cognitive function with preserved consciousness.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heparin-Induced Fever in Neurointensive Care Unit: A Rarity Yet a Possibility

Krishnakumar

Naik

Ramesh

et al. 2021

J Neuroanaesth Crit Care

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Fever is considered a protective response having multitude of benefits in terms of enhancing resistance to infection, recruiting cytokines to the injured tissue, and promoting healing. In terms of an injured brain, this becomes a double-edged sword triggering an inflammatory cascade resulting in secondary brain injury. It is important to identify the etiology so that corrective measures can be taken. Here we report a case of persistent fever in a patient with Guillain-Barré syndrome, which was probably due to heparin. This is the first report of heparin-induced fever in a neurocritical care setting and third report overall.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Heparin-Induced Fever in Neurointensive Care Unit: A Rarity Yet a Possibility

Krishnakumar

Naik

Ramesh

et al. 2021

J Neuroanaesth Crit Care

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“…d) Vaccines and allergic extracts could cause fever because both contain bacterial and virus pyrogens [6][7][8].…”

Section: Df Mechanismsmentioning

confidence: 99%

Fever as an Adverse Drug Reaction of Different Therapeutic Groups

Postnikov¹,

Teplova²,

Ermilin³

et al. 2020

AJP

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Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor -dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) -rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.

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“…3,40 Eksisi lesi harus dalam dan luas dengan margin eksisi 1 cm. 6,17 Untuk lesi yang lebih kecil dapat dilakukan eksisi lokal dengan batas yang adekuat diikuti oleh penutupan primer. Flap atau graft dapat digunakan untuk menutup lesi yang lebih besar.…”

Section: Case Reportunclassified

Hemangioma Verukosa

Rinandari¹,

Sari²

2020

MEDICINUS

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Hemangioma verukosa adalah malformasi vena verukosa terlokalisisasi berupa hemangioma kapiler atau kavernosa dengan reaksi proliferasi epidermis berupa hiperkeratosis, akantosis dan papilomatosis serta ditandai dengan proliferasi dan pelebaran vaskular pada dermis hingga subkutan. Kelainan ini biasanya ditemukan pada ekstremitas bawah dan unilateral. Hemangioma verukosa sering didiagnosis sebagai malformasi vena atau limfatik. Seorang anak laki-laki berusia 11 tahun datang dengan bercak merah kehitaman yang kasar dan berbenjol-benjol pada kaki kanan yang dimiliki sejak lahir. Empat bulan sebelumnya, bercak tersebut berdarah akibat terkena lemparan bola kemudian menjadi semakin kasar, tebal dan bertambah gelap. Diagnosis awal pasien adalah hemangioma dan dilakukan krioterapi, namun lesi tidak membaik setelah 6 kali krioterapi. Diagnosis VH harus dipertimbangkan terutama jika menemukan lesi papul, plak maupun nodul eritematosa hiperkeratotik, ada saat lahir, berlokasi di ekstremitas bawah dan menunjukkan pertumbuhan setelah trauma atau infeksi. Dari hasil anamnesis, pemeriksaan fisik, serta penunjang, pasien didiagnosis dengan hemangioma verukosa. Terapi eksisi dengan margin yang adekuat pada kasus hemangioma verukosa dapat memberikan prognosis yang baik dan tingkat kekambuhan yang rendah. Terapi pada pasien ini berupa kombinasi salep clobetasol propionate 0,05% dan salicylic acid 5% kemudian dilakukan eksisi.

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Heparin-Induced Fever: A Case Report and Literature Review

Cited by 11 publications

References 7 publications

Heparin-Induced Fever in Neurointensive Care Unit: A Rarity Yet a Possibility

Heparin-Induced Fever in Neurointensive Care Unit: A Rarity Yet a Possibility

Fever as an Adverse Drug Reaction of Different Therapeutic Groups

Hemangioma Verukosa

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