Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Chen, Li; Jiao, Tingying; Liu, Weiwei; Wang, Jue; Xiao, Tao; Lin, Zheng; Sun, Chuying; Wang, Kanglong; He, Yifan; Zhang, Yuwei; Xu, Hongwei; Wang, Jiawen; Zuo, Jian‐Ping; Ding, Qiurong; He, Shijun; Gonzalez, Frank J.; Xie, Cen

doi:10.1016/j.stem.2022.08.008

Cited by 75 publications

(42 citation statements)

References 55 publications

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“…In recent years, FXR has been identified as a potential therapeutic target for the treatment of colorectal cancer and inflammatory bowel disease (IBD). 6 The activation of the FXR by endogenous bile acids promotes intestinal cancer stem cell proliferation. 7 Similarly, activating the FXR can also promote the growth of colon stem cells in IBD mice.…”

Section: Introductionmentioning

confidence: 99%

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Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…7 Similarly, activating the FXR can also promote the growth of colon stem cells in IBD mice. 6 Nonetheless, the activation of the FXR in the normal small intestine tissue can suppress cell proliferation while antagonizing FXR-promoted cell proliferation. 8 FXR-dependent regulation of cell proliferation in different tissues is different.…”

Section: Introductionmentioning

confidence: 99%

Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor

et al. 2023

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“…Primary sclerosing cholangitis (PSC)-IBD is also the result of dysregulated Th17/Treg balance [114]. IBD patients are often accompanied by dysregulated bacterial flora, BAs and pro-inflammatory factors [115]. Genes encoding various metabolism-related enzymes in the gut flora regulate anti-inflammatory BAs small molecules and their derivatives, and they were negatively correlated with intestinal IBD [27,61].…”

Section: Bas Immune and Diseasementioning

confidence: 99%

Effect of gut flora mediated‐bile acid metabolism on intestinal immune microenvironment

Zhang

Gao

et al. 2023

Immunology

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According to reports, gut microbiota and metabolites regulate the intestinal immune microenvironment. In recent years, an increasing number of studies reported that bile acids (BAs) of intestinal flora origin affect T helper cells and regulatory T cells (Treg cells). Th17 cells play a pro‐inflammatory role and Treg cells usually act in an immunosuppressive role. In this review, we emphatically summarised the influence and corresponding mechanism of different configurations of lithocholic acid (LCA) and deoxycholic acid (DCA) on intestinal Th17 cells, Treg cells and intestinal immune microenvironment. The regulation of BAs receptors G protein‐coupled bile acid receptor 1 (GPBAR1/TGR5) and farnesoid X receptor (FXR) on immune cells and intestinal environment are elaborated. Furthermore, the potential clinical applications above were also concluded in three aspects. The above will help researchers better understand the effects of gut flora on the intestinal immune microenvironment via BAs and contribute to the development of new targeted drugs.

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“…Primary sclerosing cholangitis (PSC)-IBD is also a result of a dysregulated Th17/Treg balance 112 . IBD is often accompanied by dysregulated bacterial flora, BAs, and pro-inflammatory factors 113 . Genes encoding various metabolism-related enzymes in the gut flora regulate anti-inflammatory BAs small molecules and their derivatives, and are negatively correlated with intestinal IBD 27,61 .…”

Section: Bas Immune and Diseasementioning

confidence: 99%

Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment

Zhang

Gao

Yang

et al. 2023

Preprint

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According to reports, gut microbiota and metabolites regulate intestinal immune microenvironment. In recent years, an increasing number of studies reported that bile acids (BAs) of intestinal flora origin affects T helper cells and Treg cells. Th17 cells play a pro-inflammatory role and Treg cells usually act an immunosuppressive role. In this review, we emphatically summarized the influence and corresponding mechanism of different configurations of the LCA and DCA on intestinal Th17 cells, Treg cells and intestinal immune microenvironment. The regulation of BAs receptors G protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and farnesoid X receptor (FXR) on immune cells and intestinal environment are elaborated. Furthermore, the potential clinical applications above were also concluded in three aspects. These above will help researchers better understand the effects of gut flora on the intestinal immune microenvironment via BAs and contribute to the development of new targeted drugs.

show abstract

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Cited by 75 publications

References 55 publications

Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor

Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor

Effect of gut flora mediated‐bile acid metabolism on intestinal immune microenvironment

Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment

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