Hepatic Fibrogenic Activity in Chronic Alcoholic Pancreatitis

Valderrama, Rodrigo; Navarro, Salvador; Bruguera, Miquel; López, José Manuel; Caballería, Joan; Bianchi, L.; Pérez-Ayuso, Rosa María; Giménez, America; m., Adrian; Parés, Albert; Fernández‐Cruz, Laureano; Terés, J

doi:10.1097/00006676-199910000-00008

Cited by 3 publications

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“…Aparisi et al 22 reported that there is no overlap between patients of alcohol-induced CP and liver cirrhosis regarding clinical manifestations, imaging studies, and functional tests. However, most patients with ACP have also enhanced hepatic fibrogenic activity that leads to increased collagen deposition 4 . There was no difference in the perioperative parameters in the patients with normal liver and fibrosis on liver biopsy in the present study.…”

Section: Discussioncontrasting

confidence: 60%

“…However, most patients with ACP have also enhanced hepatic fibrogenic activity that leads to increased collagen deposition. 4 There was no difference in the perioperative parameters in the patients with normal liver and fibrosis on liver biopsy in the present study. Patients with liver fibrosis who died had low albumin, generalized swelling, and ascites, which suggest that they had progression of fibrosis resulting in hepatic decompensation.…”

Section: Discussioncontrasting

confidence: 51%

“…On the contrary, in idiopathic chronic pancreatitis (ICP), it may be due to protein-energy malnutrition or pancreatic endocrine insufficiency. Recent reports also corroborate the increased prevalence of liver fibrosis in patients with CP, and approximately 50% of the patients with liver disease in CP have cirrhosis 2,4 . However, the incidence of fibrosis without overt or histological cirrhosis and its clinical relevance is not studied well.…”

mentioning

confidence: 83%

“…Recent reports also corroborate the increased prevalence of liver fibrosis in patients with CP, and approximately 50% of the patients with liver disease in CP have cirrhosis. 2,4 However, the incidence of fibrosis without overt or histological cirrhosis and its clinical relevance is not studied well.…”

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confidence: 99%

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Histopathological Changes in Liver of Patients With Chronic Pancreatitis Requiring Surgical Intervention and Their Clinical Significance

Saluja¹,

Varshney²,

Kumar

et al. 2022

Pancreas

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ObjectivesThe histopathological changes in the liver and their clinical implication in chronic pancreatitis (CP) have not been studied well. We analyzed the incidence, risk factors, and long-term outcomes of these changes in CP.MethodsChronic pancreatitis patients who underwent surgery with intraoperative liver biopsy from 2012 to 2018 formed the study group. Based on liver histopathology, 3 groups were formed: normal liver, group NL; fatty liver, group FL; and inflammation/fibrosis, group FS. The risk factors and long-term outcomes, including mortality, were evaluated.ResultsAmong 73 patients, 39 (53.4%) had idiopathic, and 34 (46.6%) had alcoholic CP. The median age was 32 years, 52 (71.2%) were males and comprised NL, n = 40 (55%); FL, n = 22 (30%); and FS, n = 11 (15%). The preoperative risk factors were comparable among NL and FL groups. Overall 14 of 73 patients (19.2%) (NL, 5 of 40; FL, 5 of 22; FS, 4 of 11 [P = 0.82]) had died at median follow-up of 36 months (range, 25–85 months). The main causes of mortality were tuberculosis and severe malnutrition secondary to pancreatic insufficiency.ConclusionsThe mortality is higher in patients with inflammation/fibrosis or steatosis in liver biopsy, and such patients need monitoring for progression of liver disease and pancreatic insufficiency.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussioncontrasting

confidence: 51%

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confidence: 83%

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confidence: 99%

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