Hepatic intra-arterial injection of 1,25-dihydroxyvitamin D3 in lipiodol: Pilot study in patients with hepatocellular carcinoma

Morris, David L.; Jourdan, J; Finlay, I. G.; Gruenberger, Thomas; Pourgholami, Mohammad H.

doi:10.3892/ijo.21.4.901

Cited by 11 publications

(9 citation statements)

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“…Results obtained revealed that, while in three patients the calcium levels exceeded the normal range, even at these extremely high doses of 1,25-(OH) 2 D 3 , non of the patients developed grade 3 hypercalcemia. 1,25-(OH) 2 D 3 administration also led to transient stabilization of serum ␣-fetoprotein in some patients [49]. The data obtained support the hypothesis that, in patients with HCC, IHA delivery of 1,25-(OH) 2 D 3 in lipiodol can allow administration of supra-pharmacological doses of the drug with out the development of hypercalcemia.…”

Section: Phase I Clinical Trial Of Iha Administration Of 125-(oh) 2 supporting

confidence: 69%

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Pourgholami

Morris

2004

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Phase I Clinical Trial Of Iha Administration Of 125-(oh) 2 supporting

confidence: 69%

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Pourgholami

Morris

2004

The Journal of Steroid Biochemistry and Molecular Biology

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“…PCR products of the MnSOD enhancer region and RelB amounts in (A) and expression of MnSOD shown in the three panels of (B) were normalized by the relating controls, and fold increases or decreases were calculated by normalizing amounts in the treated groups with the untreated controls as described in prostate cancer cells (27) (44,45). Alternative routes of administration have been used in patients with hepatocellular carcinoma (46). Although the effectiveness of regional administration of 1a,25-(OH) 2 D 3 remains to be proven, it is interesting to note that the prostate is one organ most amendable to such an approach.…”

Section: Discussionmentioning

confidence: 99%

Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1α,25-dihydroxyvitamin D3 in prostate cancer cells

Xu¹,

Fang

Clair³

et al. 2007

Molecular Cancer Therapeutics

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Nuclear factor-KB provides an adaptive response to protect cancer cells against cytotoxicity induced by redox active therapeutics. RelB is uniquely expressed at a high level in prostate cancer with high Gleason scores. Recently, we showed that the level of RelB rapidly increases in androgen-independent prostate cancer cells after exposure to ionizing radiation (IR), leading to a reduction in intrinsic radiosensitivity. Here, we show that interaction of 1A,25-dihydroxyvitamin D 3 [1A,25-(OH) 2 D 3 ] with the vitamin D receptor significantly enhances radiosensitivity of prostate cancer cells at clinically relevant radiation doses. The radiosensitization effect of 1A,25-(OH) 2 D 3 is mediated, at least in part, by selectively suppressing IR-mediated RelB activation, leading to a reduced expression of its target gene MnSOD, a primary antioxidant enzyme in mitochondria. These results suggest that suppression of manganese superoxide dismutase is a mechanism by which 1A,25-(OH) 2 D 3 exerts its radiosensitization effect and that 1A,25-(OH) 2 D 3 may serve as an effective pharmacologic agent for selectively sensitizing prostate cancer cells to IR via suppression of antioxidant responses in mitochondria.

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“…In a phase 1 clinical trial the safety of high doses of vitamin D administered in lipiodol and directly injected into the hepatic artery of 8 patients with refractory HCC was evaluated[ 152 ]. Lipiodol is an oily substance consisting of polyunsaturated esters enriched in iodine used as a vector for chemoembolization or internal radiotherapy in unresectable HCCs[ 153 ].…”

Section: Vitamin D and Its Analogues In Hcc Preventionmentioning

confidence: 99%

“…Lipiodol is an oily substance consisting of polyunsaturated esters enriched in iodine used as a vector for chemoembolization or internal radiotherapy in unresectable HCCs[ 153 ]. Although this study was not specifically designed as a pilot study of vitamin D efficacy in HCC, the results showed a certain stabilization of tumor marker levels, suggesting some efficacy of vitamin D[ 152 ]. Another clinical trial (ClinicalTrials.gov; identifier NCT01575717) is currently performed to assess the effect of two different doses of vitamin D3 (2000 IU vs 4000 IU) on serum 25OHD levels in HCC patients on liver transplant lists.…”

Section: Vitamin D and Its Analogues In Hcc Preventionmentioning

confidence: 99%

Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review

Hoàn

Tong

Song

et al. 2018

WJG

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The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses (HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response (SVR) to interferon (IFN) plus ribavirin (RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBV- and HCV-related chronic liver diseases. Furthermore, current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients.

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Hepatic intra-arterial injection of 1,25-dihydroxyvitamin D3 in lipiodol: Pilot study in patients with hepatocellular carcinoma

Cited by 11 publications

References 0 publications

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1α,25-dihydroxyvitamin D3 in prostate cancer cells

Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review

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