Hepatic lipase activity increases after liver denervation in the rat

Hansson, Per; Lindfeldt, J.; Ekelund, Mats; Kullendorff, Carl‐Magnus; Holmin, T.; Nilsson‐Ehle, Peter

doi:10.1016/0005-2760(85)90209-7

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…The tissue was immediately frozen at -70 "C to allow analysis of all samples in the same series. SRL activity was determined as described previously for the enzyme activity in liver tissue [8]. Briefly, the adrenal tissue was homogenized and the floating fat removed by centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Salt resistant lipase activity in human adrenal gland is increased in Cushing's disease

Berg

Hansson

Nilsson‐Ehle

1990

Journal of Internal Medicine

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Salt resistant lipase (also designated hepatic lipase) is present in normal human adrenal cortex at activity levels of about 1 mU g-1 tissue wet weight. In hyperplastic adrenocortical tissue from four patients with Cushing's disease the salt resistant lipase activity was found to be about 5-fold higher than this value. The activity of salt resistant lipase in postheparin plasma was elevated in two of the patients, indicating that the high enzyme activity in adrenal cortex may originate from the liver. Lipoprotein lipase activity in postheparin plasma was clearly depressed in all patients with Cushing's disease and was associated with moderate hypertriglyceridaemia and slightly lowered HDL cholesterol levels. Thus high ACTH and/or corticosteroid levels appear to affect lipoprotein metabolism by a number of mechanisms.

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Section: Methodsmentioning

confidence: 99%

Salt resistant lipase activity in human adrenal gland is increased in Cushing's disease

Berg

Hansson

Nilsson‐Ehle

1990

Journal of Internal Medicine

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“…Hepatic lipase activity in the liver tissue was determined as described by Hansson et al (7). Briefly, the tissue was homogenized, and floating fat removed by centrifuga¬ tion.…”

Section: Methodsmentioning

confidence: 99%

“…They were housed in single cages on a 06.00-18.00 h light cycle at 23°C. The rats received chow ad libitum; no effect by hepatic hilar denervation on feeding was recorded in an earlier study (7). Prior to operation, all animals were provided with 6-n-propyl-2-thiouracil (PTU) in the drinking water (0.1 g/1) during 8 days.…”

Section: Animals and Surgical Proceduresmentioning

confidence: 99%

“…Metabolic control of hepatic lipase is mediated by hormones, such as insulin, gestagens (2)(3)(4)(5), and thyroid hormones (6). Nervous regulation of he¬ patic lipase activity has also been demonstrated; rats denervated at the liver hilus had a 20% higher enzyme activity than sham-operated controls (7).…”

mentioning

confidence: 99%

“…The purpose of the present study was to investigate the effects of two denervation proce¬ dures, hepatic hilar denervation and hepatic vago¬ tomy, on the regulation of hepatic lipase activity. To amplify the possible stimulatory effect of de¬ nervation (7) we conducted the experiment in hy-pothyroid rats, which have a decreased hepatic lipase activity (9).…”

mentioning

confidence: 99%

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Hepatic lipase activity after liver denervation in hypothyroid rats

Berg

Hammarström²,

Hansson³

et al. 1990

Acta Endocrinologica

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Hepatic hilar denervation, hepatic vagotomy or sham operation were performed in hypothyroid rats. Activities of hepatic lipase were measured nine days after surgery. Sham operation in itself was associated with a decrease of hepatic lipase activity by about 40% compared with non-operated animals. Both hilar denervation and hepatic vagotomy were associated with increased hepatic lipase activity (40% and 35%, compared with sham-operated animals). Liver contents of norepinephrine were reduced by about 90% after hilar denervation, whereas hepatic vagotomy did not affect norepinephrine levels. No major changes in lipids and lipoproteins were noted.

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