Hepatitis E virus antibodies among patients with hemophilia, blood donors, and hepatitis patients

Zaaijer, Hans L.; Mauser‐Bunschoten, E. P.; Veen, J; Kapprell, Hans-Peter; M, Kok; Berg, H. M. Van Den; Lelie, P. N.

doi:10.1002/jmv.1890460313

Cited by 38 publications

(37 citation statements)

References 8 publications

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“…In Brazil (a country where HEV is nonendemic), 2.6 to 3% of healthy blood donors were found to have HEV antibodies (10). Similarly, the presence of HEV antibodies was reported in countries where HEV is nonendemic in Europe, including Spain, Sweden, Germany, Greece, England, Finland, Italy, and The Netherlands (1,15,16,42,43). Similar data were observed in human populations in Ontario (M. Fearon [Ontario Ministry of Health, Toronto, Ontario], personal communication).…”

Section: Discussionmentioning

confidence: 86%

Prevalence of Hepatitis E Virus Antibodies in Canadian Swine Herds and Identification of a Novel Variant of Swine Hepatitis E Virus

Yoo

Willson²,

Pei

et al. 2001

Clin Diagn Lab Immunol

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Swine hepatitis E virus is a newly identified potentially zoonotic virus from pigs of particular concern for possible direct transmission to a human xenotransplant recipient by organ transplantation. In the present study, prevalence of serum antibodies to hepatitis E virus was examined in Canadian swine herds. A total of 998 serum samples collected from 6-month-old healthy slaughter hogs were examined by enzyme immunoassay and Western blot analysis for antibodies to the recombinant open reading frame 3 (ORF3) protein of hepatitis E virus expressed in Escherichia coli. These samples represented more than 80 different swine production units from five major swine-producing provinces across Canada. From this study, 594 samples (59.4%) were found to be positive for hepatitis E virus antibody. The seroprevalence was higher in Quebec (88.8%) and Ontario (80.1%) than in Alberta and Saskatchewan (38.3%). By PCR using a pair of oligonucleotide primers deduced from the ORF2 sequence of human hepatitis E virus, a specific hepatitis E virus sequence was recovered from feces of pigs. The nucleotide sequence identity between the U.S. swine hepatitis E virus and the Canadian isolate (SK3) was only 85.8%, suggesting that genotypic variations may exist in swine hepatitis E virus in North America. Among 165 serum samples collected from humans in Saskatchewan, 2.4% were found to be positive for antibodies to the hepatitis E virus ORF3 protein. Our data indicate that hepatitis E virus is highly prevalent in commercial swine populations in Canada and support the suggestion that the swine hepatitis E virus may be an important zoonotic agent for humans.

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Section: Discussionmentioning

confidence: 86%

Prevalence of Hepatitis E Virus Antibodies in Canadian Swine Herds and Identification of a Novel Variant of Swine Hepatitis E Virus

Yoo

Willson²,

Pei

et al. 2001

Clin Diagn Lab Immunol

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“…They also suggested that the parenteral transmission of HEV may have occurred in Japanese patients with hemophilia via non-virus-inactivated coagulation factors (34). Other studies in different countries showed lower HEV seropositivity among hemophilia patients (45)(46)(47)(48) than Japan.…”

Section: Discussionmentioning

confidence: 99%

The Seroprevalence of Entrically Transmitted Viral Hepatitis in HCV Infected Thalassemia and Hemophilia Patients in Iran

Elizee

Alavian

Miri

et al. 2013

Jundishapur J Microbiol

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Background: Hepatitis A and E virus (HAV and HEV) infections are acute and self-limited diseases that usually spread through oral-fecal route. Also, blood transfusion as a possible route of entrically transmitted hepatitis has been suggested. Hemophilia and thalassemia patients are highly at risk of transfusion-transmissible viruses (HBV, HCV, and HIV). Any superimposed infection with other viral hepatitis (in particular hepatitis A) cause active liver failure in hemophilia and thalassemia patients. Objectives: The aim of this study is to consider seroprevalence of anti HAV and HEV antibodies (Ab) in thalassemia and hemophilia patients with chronic hepatitis C in Iran. Patients and Methods:In a cross-sectional study and under general census sampling, sera of 219 thalassemia and hemophilia patients infected with HCV were examined in Tehran Hepatitis Center (THC) between 2009 and 2010. Enzyme-linked immunisorbentassey (ELISA) was done to observe anti HAV and HEV IgG Ab. Patients were chosen from all provinces of Iran. Results: Anti-HAV IgG antibodies were observed more frequently in thalassemia patients (60/64; 93.8%) than in hemophilia patients (104/155; 67.1%, P < 0.001). The seroprevalence of both antibodies increased with age. Among thalassemia patients, there was no significant association between HAV seropositivity and other variables, but in hemophilia group, seropositive patients were significantly older than seronegative group (P < 0.05). Totally, anti HEV Ab (1/64; 1.6% thalassemia and 5/155; 3.2% hemophilia) was seropositive in six patients. There was no significant association between HEV infection and other variables in thalassemia patients, however, in hemophilia patients, HEV positive ones were significantly older than HEV negative group (P=0.01). Conclusions: Vaccination of non-immune individuals against HAV infection in high risk groups especially hemophilia and thalassemia patients is recommended. Results did not show any differences about seroprevalence of HEV among Iranian general population.

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“…In der Regel war dabei unbekannt, ob die Infektion auf die Gabe von Blutprodukten zurückzuführen war oder auf anderem Weg erworben worden war. In der Literatur sind nur wenige Untersuchungen von Hämophiliepatienten berichtet worden [196,197]; in keiner dieser Untersuchungen gab es Hinweise auf ein erkennbares HEV-Infektionsrisiko durch Gerinnungspräparate. Allerdings wurde in einer japanischen Studie bei äl-teren Hämophiliepatienten, die auch mit nicht virusinaktivierten Gerinnungsprä-paraten behandelt worden waren, eine erhöhte Antikörperprävalenz festgestellt [198].…”

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