Hepato-nephro-toxicity Induced by Premium Fungicide and Protective Effect of Sesame Oil

Ziada, Reem M.; Abdulrhman, Sanaa M.; Nahas, A. A.

doi:10.21608/ejhm.2020.133961

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…Ziada and Abdulrhman ( 2020 ) reported that the AZ fungicide induced liver and kidney damage, as shown by the elevated function bioindicators. As a result of the AZ impact, GSH was reduced while MDA was increased dramatically.…”

Section: Discussionmentioning

confidence: 99%

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Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

El-Hak

Al-Eisa

Ryad

et al. 2022

Environ Sci Pollut Res

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Acetamiprid (neonicotinoid insecticide) and azoxystrobin (fungicide) are widespread pesticides used for pest management, but they have the potential for toxicity to mammals. The goal of this study was to look for oxidative stress, metabolic alterations, and reproductive problems in male rats’ serum after 2 months of exposure to sub-lethal dosages of acetamiprid and azoxystrobin. Seven classes of male rats were formed: control, 3 groups of acetamiprid (1/10, 1/20, 1/40 LD50), and 3 groups of azoxystrobin (1/10, 1/20, 1/40 LD50) and were orally daily treated (n = 8/group). Our findings revealed that acetamiprid and azoxystrobin disrupted oxidative and metabolic processes in the examined rats throughout 30 and 60 days of testing. The levels of nitric oxide increased significantly, while catalase, a superoxide dismutase enzyme, and glutathione reductase activity were reduced. Serum levels of sex hormones, calcium, and total protein have all dropped substantially in rats. In comparison to the control group, the testis and liver structure, as well as spermatozoa parameters, had distinct histological characteristics. In conclusion, acetamiprid and azoxystrobin exhibit dose- and time-dependent effects on oxidative parameters that cause testis damage.

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Section: Discussionmentioning

confidence: 99%

“…The inflammatory response includes the migration and activation of both resident and circulating inflammatory cells, as well as the release of cytokines. Activated inflammatory cells and released cytokines induce fibroblasts to replicate, migrate, secrete and produce collagen (Ziada and Abdulrhman 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

El-Hak

Al-Eisa

Ryad

et al. 2022

Environ Sci Pollut Res

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“…The herbicide 2,4-D has been related to tubular damage, glomerular alterations, vascular congestion, and an increased number of pyknotic nuclei in the kidneys of rats [ 21 ]. In addition, azoxystrobin fungicide administration in rats showed degeneration of tubular epithelial cells and hemorrhage in the intratubular spaces [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Herbicides’ effects on rat kidneys include marked proximal and distal tubular lesions showing coagulation necrosis with tubular cell loss [ 20 , 21 , 22 ]. Fungicides have also been related to degeneration of some tubular epithelial cells and hemorrhage in rat kidneys [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study

Meyer

Santos

Asmus

et al. 2022

IJERPH

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Recent evidence suggests that pesticides may play a role in chronic kidney disease. However, little is known about associations with acute kidney failure (AKF). We investigated trends in AKF and pesticide expenditures and associations with agricultural work in two Brazilian regions with intense use of pesticides, in the south and midwest. Using death certificate data, we investigated trends in AKF mortality (1980–2014). We used joinpoint regression to calculate annual percent changes in AKF mortality rates by urban/rural status and, in rural municipalities, by tertiles of per capita pesticide expenditures. We then compared AKF mortality in farmers and population controls from 2006 to 2014 using logistic regression to estimate odds ratios and 95% confidence intervals adjusted by age, sex, region, education, and race. AKF mortality increased in both regions regardless of urban/rural status; trends were steeper from the mid-1990s to 2000s, and in rural municipalities, they were higher by tertiles of pesticide expenditures. Agricultural workers were more likely to die from AKF than from other causes, especially at younger ages, among females, and in the southern municipalities. We observed increasing AKF mortality in rural areas with greater pesticide expenditures and an association of AKF mortality with agricultural work, especially among younger workers.

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“…So, there is a great interest in bioactive natural compounds due to their protective properties against both the toxicity of various toxins and other pathogenic factors, especially ROS [16]. The plant extracts do their preservative impact through free radicals scavenging and the antioxidant defense mechanism modulating [10]. Therefore, the current study was undertaken to estimate the effectiveness of boldo extract against Amistar-induced biological alterations in male rats.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective impact of Boldo (Peumus boldus) extract against azoxystrobin induced DNA damage, gene expression modulation, biochemical and histopathological alterations mediated-ROS generation in male rats

et al. 2022

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Peumus boldus Molina, ordinarily mentioned to as 'boldo', is expended in folk medicine to cure gastrointestinal and hepatic diseases. This plant is wealthy in several antioxidant compounds. The current research evaluated the ameliorative effect of boldo leaves extract on lipid peroxidation, liver antioxidant enzymes, ROS generation, DNA damage, gene expression, and histopathological changes induced by Amistar fungicide in male rats. The rats were allocated in four groups treated with boldo extract (50 mg/Kg b.w) and/or with Amistar (1/20 of LD50). As likely, the treatment with fungicide significantly (P<0.05) decreased the antioxidant enzymes activities, while increasing the liver biomarker parameters, lipid peroxidation, ROS generation, DNA damage, and hepatic tissue lesions as well as altered the expression of stress and antioxidant related genes in comparison with control rats. Pretreatment with boldo extract significantly improved the negative effects induced by Amistar on the liver cells. The research results indicate that the boldo extract acts as a defender against the oxidative hepatic injury produced by fungicide. The defensive capability of boldo extract could be owing to the existence of natural antioxidants and anti-inflammatory constituents' likes gallic acid, ellagic acid, querectin, daidzein, ferulic acid and rutin.

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Hepato-nephro-toxicity Induced by Premium Fungicide and Protective Effect of Sesame Oil

Cited by 7 publications

References 13 publications

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats

Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study

Hepatoprotective impact of Boldo (Peumus boldus) extract against azoxystrobin induced DNA damage, gene expression modulation, biochemical and histopathological alterations mediated-ROS generation in male rats

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