Hepatobiliary and Pancreatic: Liver transplantation for massive hepatic lymphangiomatosis

Aw, Lee; Rajanayagam, Jeremy; Sarikwal, Anubhav; Davies, Janene; Lewindon, P. J.

doi:10.1111/jgh.12493

Cited by 5 publications

(4 citation statements)

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“…[6,7] Few studies reported the association between liver cirrhosis and DPL and hepatic lymphangiomatosis is not common. [8] Our case was combined cirrhotic and hepatic encephalopathy for 20-year, with no obvious cause. It is puzzled to us that the symptoms of HE can be relieved without no treatment.…”

Section: Discussionmentioning

confidence: 96%

Diffuse pulmonary lymphangiomatosis

Yu¹,

Mi²,

Cong³

et al. 2019

Medicine

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Rationale:Diffuse pulmonary lymphangiomatos (DPL) is a rare aggressive lymphatic disorder characterized by proliferation of anastomozing lymphatic vessels and extremely rare in adult patients.Patient concerns:We report a case of diffuse pulmonary lymphangiomatosis in 59-year-old man presented with cough and sputum for 2 months.Diagnoses:Combining clinical manifestations with results of radiological, bronchoscopy, and surgical lung biopsy, it was consistent with the diagnosis of DPL.Interventions:After bronchoalveolar lavage and biopsy, symptom of cough got worse suddenly accompanied by excessive chyloptysis. The patient received an emergency surgical intervention and low fat medium chain fat treatment.Outcomes:The patient was discharged with a much better health condition.Lessons:This case report is the oldest patient reported in the English literature, to the best of our knowledge. Serious complications of bronchoscopy should be considered, especially in DPL patients with severely enlarged mediastinum or with thin-walled translucent vesicles under endoscopy.

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Section: Discussionmentioning

confidence: 96%

Diffuse pulmonary lymphangiomatosis

Yu¹,

Mi²,

Cong³

et al. 2019

Medicine

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“…Hepatic lymphangioma is usually considered a benign tumor[ 20 , 33 ]. Treatments for hepatic lymphangioma include complete resection, partial resection with cleaning cystic fluid, needle aspiration, sclerosing agent injection, liver transplantation, and immunosuppressive drugs for diffused and serious condition[ 11 , 12 , 34 - 36 ]. Partial resection with cleaning cystic fluid and needle aspiration can definitely lead to tumor recurrence[ 32 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The use of immunosuppressive agents to treat hepatic lymphangioma or lymphangiomatosis has not been approved[ 12 , 38 ]. Liver transplantation is the last choice for hepatic lymphangiomatosis with deteriorated liver function and progressing symptoms affecting the quality of life[ 11 , 12 , 34 , 35 , 37 ]. It is thought that hepatic lymphangioma or lymphangiomatosis is a low grade malignancy or has the potential to metastasize as hepatic recurrence is observed even after liver transplantation[ 12 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Less than 5% of intra-abdominal lymphangiomas are described, and the most frequently affected location is the small bowel mesentery, followed by the omentum, mesocolon, and retroperitoneum[ 9 , 10 ]. When lymphangiomas affect multiple organs, including the liver, spleen, soft tissues, serosa (mesentery), peritoneum, retroperitoneum, and skeletal, the situation is named lymphangiomatosis, which could not be eradicated by surgery but may respond to systemic chemotherapy and radiotherapy with limited efficacy and poor prognosis[ 11 - 13 ]. In addition, solitary lesions in the liver are rare and are further classified into capillary lymphangioma, cystic lymphangioma, and cavernous lymphangioma[ 4 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Solitary hepatic lymphangioma mimicking liver malignancy: A case report and literature review

Long¹,

Zhang²,

Cheng³

et al. 2020

WJCC

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BACKGROUND Hepatic lymphangioma, a malformation of the liver lymphatic system, is a rare benign neoplasm and usually coexists with other visceral lymphangiomas. Solitary hepatic lymphangioma is much more rarely seen and could cause a clinical misinterpretation as malignancy. CASE SUMMARY A 50-year-old woman with a liver mass of approximately 3.5 cm was initially diagnosed with hepatocellular carcinoma given the risk factors for liver cancer that she presented with, including Schistosome japonicum infection and jaundice, and also together with imaging results, which showed the mass enhanced quickly in the arterial phase and faded fast in the venous phase. The patient did not have the surgery first but received three rounds of transarterial chemoembolization because of her anxiety and fears for operation. Finally, the patient underwent laparoscopic liver segment 4b resection and cholecystectomy and was discharged from the hospital only 10 d after the operation. The pathological examination indicated the mass as hepatic lymphangioma. The patient has been followed up for 30 mo without recurrence. To raise the awareness of this misdiagnosed case and to better diagnose and treat this rare disease in future, we reviewed the published literature of solitary hepatic lymphangioma for its clinical symptoms, imaging presentation, operative techniques, histology features and prognosis. CONCLUSION Solitary hepatic lymphangioma mimicking malignancy makes diagnosis difficult. Complete surgical resection is the first choice to treat solitary hepatic lymphangioma.

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