Hepatoblastoma in an Equine Fetus

Neu, Suzanne M.

doi:10.1177/104063879300500426

Cited by 23 publications

(28 citation statements)

References 14 publications

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“…In 6 out of 9 cases, at postmortem examination, the left liver lobe contained the primary tumor with metastases to other lobes. 3,8,13,21,22,27,29 In the cases presented herein, the affected lobe was not recorded in horse fetus no. 1, and in horse no.…”

Section: Discussionmentioning

confidence: 73%

“…3,8,13,21,22,27,29 Traumatic rupture of these tumors as a result of dystocia was reported in equine neonates 22 and have also been reported in humans. 34 Juvenile horses frequently presented with a nonspecific history of lethargy, fever, inappetence, weight loss, diarrhea, and mucous membrane congestion.…”

Section: Discussionmentioning

confidence: 90%

“…2 the primary site involved the right liver lobe. Numerous metastatic sites outside the liver have been reported, 3,8,13,21,22,27,29 including 1 case that reported omental and mesenteric tumors. 29 The latter finding is inconsistent with those reported for humans, where HB was rarely, if ever, metastatic to abdominal lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…5,10,12,16,38 Primary equine liver tumors are rare, with only 17 cases reported, of which 9 were classified as HB (Table 1). 3,4,8,13,18,19,21,22,24,27,29,32,33,35 Other reports of primary hepatic tumors in fetuses and juvenile horses included mixed hamartoma, 33 mesenchymal hamartoma, 4 and HCC. 18,32 In mature horses, cholangiocellular carcinoma 24 and combined HCC and cholangiocarcinoma have also been diagnosed ( Table 2).…”

Section: Introductionmentioning

confidence: 99%

“…16 The number of reports of equine HB is too low to make generalizations, but the primary tumor was in the left liver lobe in 6 out of 9 equine HB cases. 3,8,13,21,22,27,29 Ultrasonographically, human HB typically appeared as a lobulated, vascular, solid mass with calcification and hypoechoic areas that may have indicated necrosis or hemorrhage. 34 Metastases to abdominal lymph nodes are considered rare in HB but not in HCC.…”

Section: Introductionmentioning

confidence: 99%

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Equine Primary Liver Tumors: A Case Series and Review of the Literature

et al. 2010

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Abstract. Hepatoblastoma (HB) is an uncommon pediatric liver tumor in humans and horses. In humans, HB is most frequently diagnosed in fetuses, neonates, and young children, whereas hepatocellular carcinoma (HCC) affects juvenile and adult humans. Hepatoblastoma in the horse is rare, with only 9 reported cases. Affected horses ranged in age from late-term aborted fetuses to 3 years. The current study describes 3 new cases of primary liver tumors in horses and reviews findings in relation to other reports on this condition. Tumors classified as HB were identified in a male Standardbred aborted fetus and in a 4-year-old Thoroughbred filly. Hepatocellular carcinoma was diagnosed in a 15-month-old Paint filly. In the Standardbred fetus, the tumor was only present in the liver. In the Thoroughbred and Paint fillies, primary tumors were in the right liver lobe and at the hilus, respectively, and there were metastases to other lobes (HB) and mesenteric lymph nodes (HCC). Tumors were sharply demarcated from adjacent tissue, nonencapsulated, compressive, and invasive. Consisting of cords and nests, or disorganized sheets of epithelial cells, tumors had variable stromal and vascular components. The fetal tumor contained areas of smaller, less differentiated cells with a pronounced mesenchymal component interpreted to be embryonal hepatic tissue. Diagnoses were based on tumor histomorphologic features, resemblance to hepatocyte developmental stages, age of the animal, and patterns of metastasis. Tumors classified as HB were a-fetoprotein immunoreactive. Primary hepatic tumors in the horse are diverse in morphology and include subtypes compatible with classification criteria applied to human tumors.

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