2013
DOI: 10.1016/j.dld.2012.08.018
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Hepatocellular carcinoma in patients without cirrhosis in Italy

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Cited by 41 publications
(40 citation statements)
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“…This goes along with data previously reported in which 12% to 21.4% of patients with HCC in NCL abused alcohol [4,5,7]. This suggests that cirrhosis is not a condition sine qua non in alcoholic liver disease for HCC development.…”
Section: Discussionsupporting
confidence: 88%
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“…This goes along with data previously reported in which 12% to 21.4% of patients with HCC in NCL abused alcohol [4,5,7]. This suggests that cirrhosis is not a condition sine qua non in alcoholic liver disease for HCC development.…”
Section: Discussionsupporting
confidence: 88%
“…The three main risk factors for HCC (HBV or HCV infection and alcohol abuse) are less frequent than in patients with LC. Patients with HCC in NCL present at more advanced tumor stages than patients with HCC in LC [4,7] because tumors are generally detected when the disease has become symptomatic. The reason for this is that HCC in LC are frequently detected during surveillance ultrasound.…”
Section: Introductionmentioning
confidence: 99%
“…[18][19][20] While the post resection five-year survival rates for a non-cirrhotic liver (44-58%) remain higher than survival post resection for a cirrhotic liver (23-48%), the prognosis remains dismal. 5 Despite this patient's Childs-Pugh score of A, she died due to surgical complications caused by the extensive size of the tumor.…”
Section: Discussionmentioning
confidence: 99%
“…This delay in diagnosis is often why such patients have larger tumor burdens at initial presentation with an average of 12 cm compared to cirrhotic HCC with variable but often smaller sizes. 5 Current clinical evidence suggests that the first step of management for patients who have preserved hepatic function (Childs-Pugh score A) and a solitary mass is resection. 17 Despite preserved liver function, patients with non-cirrhotic HCC do not have significantly higher rates of survival than do patients with cirrhotic HCC.…”
Section: Discussionmentioning
confidence: 99%
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