Hepatoprotective Activity Combination of Curanga Fel-Terrae Lour Leaves and Curcuma Heyneana Valeton and Zijp Rhizome in Rat Induced by Combination of Rifampin and Isoniazid

Abstract

Objective: The liver is a vital organ in the body, it is often exposured to the xenobiotics that can cause injury. Pugun tano (Curanga fel-terrae) and temu giring (Curcuma heyneana) are plants that have been claimed to cure many ailments including protecting the liver. But the hepatoprotective properties of the combination of these plants has not been well studied. In this regard, the current study was undertaken to evaluate the activity combination of those plants. Methods:The male Wistar rats were divided into 6 groups, group I was a negative control (CMC-Na); group II-IV were the treatment groups and were given combination extracts at the doses of 50 mg/kg, 75 mg/kg and 100 mg/kg respectively; group V was positive control (catechin) and group VI was normal control. All of groups except group VI were given combination rifampin 100 mg/kg and isoniazid 50 mg/kg for 15 d along with administration of extracts. At the day 16, rats were sacrificed. Histopathology of the liver and biochemical assay of blood was done at the end of the administration. Results:The administration of the combination of C. fel-terrae and C. heyneana at the doses of 75 and 100 mg/kg significantly inhibited the elevation of aspartate aminotransferase (AST) and alanine transaminase (ALT) compared to negative control (p<0.05). Histopathological assessment of the liver was comparable to the normal control (p>0.05). Conclusion:The combination of C. fel-terrae and C. heyneana at the dose of 75 and 100 mg/kg is able to protect the liver from damage induced by rifampin and isoniazid.

Effectiveness of Pugun Tanoh Leaves Ethanol Extract (Curanga fel-terrae (Lour.) Merr) as an Anti-inflammation in Patients after Tooth Extraction at Dental and Mouth Hospital of Dentistry Faculty, Universitas Sumatera Utara

“…In 2014 and 2015, the study continued with hepatoprotective activity. It was proven that the ethanol extract of C. fel-terrae leaves at a dose of 125 mg/kg had hepatoprotective activity and had the same effect as catechins [7]. Acute toxicity, subchronic, and teratogenic tests have also been carried out so that the extract of C. fel-terrae leaves is safe for use in humans.…”

PHYTOCHEMICAL CONSTITUENT OF Picria fel-terrae Lour. ETHANOL EXTRACT AND ITS TERATOGENIC EFFECT

“…Some researches have been carried out to this plant and reported has many activities such as a diuretic, acetylcholinesterase inhibitor, hepatoprotective, anticancer, antidiabetic, antiasthma as well as anthelmintic. [1][2][3][4][5][6][7][8][9] The various benefits derived from P. fel-terrae as a medicinal plant are potential to be developed into a safe and easy-to-use herbal medicine preparation including for pregnant women. To obtain herbal medicine which safe for human use, a series of toxicity tests are required.…”