Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family

Ahmed, Bahar; Alam, Tanveer; Varshney, Manoj; Khan, Shah Alam

doi:10.1016/s0378-8741(01)00392-0

Cited by 74 publications

(57 citation statements)

References 13 publications

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“…The results of the present study are in agreement with this finding and demonstrate the decreased functional ability of CCl 4 -injected rat livers (33). Decreased serum TP and albumin levels have been reported in CCl 4 -administered rats (38). In contrast, a significant increase in the serum TP and albumin levels was observed in the groups that received both arbutin and CCl 4 .…”

Section: Discussionsupporting

confidence: 92%

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Mirshahvalad

Feizi

Barkhordar

et al. 2016

Jundishapur J Nat Pharm Prod

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Section: Discussionsupporting

confidence: 92%

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Mirshahvalad

Feizi

Barkhordar

et al. 2016

Jundishapur J Nat Pharm Prod

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“…The results of this study corroborate the works of several authors [16][17][18] who have shown that following the injection of a substance inducing hepatotoxicity like DNPH, an increase of liver weight of rats, as well as the relative liver weight of rats were observed. The increase in value of T-BIL and D-BIL 9,19 and decrease of ALB 12,20 are also associated to DNPH induced liver toxicity. 21 Hepatic cytolysis, loss of biochemical functions generate the inhibition of ALB production, expressed by a decrease in ALB.…”

Section: Discussionmentioning

confidence: 97%

“…10 Liver diseases are numerous and mainly caused by infections (viral, bacterial, fungal, and parasitic), hepatotoxic substances, excessive intake of alcohol and toxins. 11 The use of plants, especially H. sabdariffa, in the treatment and prevention of liver diseases is confirmed and justified by very recent and important works 11,12 which showed that generally, medicinal plants play a crucial role in protecting the liver. In addition to that, the availability of this species and especially the use of its petals as food fall has become a habit for African populations.…”

Section: Introductionmentioning

confidence: 98%

Hepatoprotective and antioxidant activities of <i>Hibiscus sabdariffa</i> petal extracts in Wistar rats

Obouayeba

Boyvin

M’boh

et al. 2014

Int J Basic Clin Pharmacol

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Background: Hibiscus sabdariffa is a medicinal plant rich in phytochemical compounds, which is the source of its biological properties. This study on the aqueous extract of H. sabdariffa (AEHS) was conducted to assess its hepatoprotective and antioxidant properties. Methods: It was carried out with 25 Wistar rats divided into five groups. Two groups were treated with a solution of NaCl 0.9%. One group was treated with silymarin at a dose of 25 mg/kg body weight (BW). Two other groups were treated with the AEHS at different doses (100 and 200 mg/kg BW). The treatments were carried out via oral route and at single dose for 7 days. After injection of 2,4-dinitrophenylhydrazine (DNPH), blood samples were collected for the carrying out of biochemical analyses of oxidative stress markers (thiobarbituric acid reactive substances, ferric reduction antioxidant parameter, and 2,2-diphenyl-1-picrylhydrazyl) and hepatotoxicity (albumin, total and direct bilirubin, alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase). Results: Three major results were obtained. The hepatotoxicity of DNPH expressed by the rats of Group 1 was significantly different (p<0.05) from those of the other groups (control, 2-4) for both hepatotoxicity and oxidative stress markers. The hepatoprotective and antioxidant properties of the AEHS and confirmation of those of silymarin through the rats of Groups 2-4 were statistically identical (p<0.05) to the control group for markers of hepatotoxicity and oxidative stress. Conclusion: These results confirm and reinforce certain therapeutic virtues of H. sabdariffa.

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“…On the other hand, some of them reported that, excess alcohol consumption has been linked with altered liver metabolism and liver damage [19]. At reverse, the results obtained by others found a decrease in serum total proteins and albumin in ethanol administered rats [20]. They suggested that this decrease was due to a reduction in the functional ability of liver by ethanol.…”

Section: Discussionmentioning

confidence: 98%

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Elhag¹,

Bernard²,

Badwi³

2017

ABB

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This study was implemented at the University of Khartoum to investigate the protective effect of camel milk mixed with camel urine against alcohol-induced liver damage in Wistar albino rats. The reasons for combining camel milk and urine together are because that in Sudan this combination is used extensively in traditional medicine and they claimed that this combination cures a lot of diseases including liver disease and jaundice; 25 Wister Albino rats of both sexes were brought and divided into 5 groups. Group 1 (control group) received normal saline, group 2 received ethanol 10% at dose of (0.5 g/100g body weight) and group 3 rats received Silymarin (5 mg/100g body weight) plus ethanol 10% (0.5 g/100g). Group 4 received a mixture of camel milk and urine (1:1) at the rate of 2 ml/100g and group 5 rats were administered with the mixture of camel's milk and urine as in group 4 plus ethanol 10% (0.5 g/100g). All treatments given by an oral intubation, experiment lasts for 28 days, rats were euthanized, serum samples and liver sections obtained. Oral administration of 10% ethanol (0.5 g/100g) induced liver damage which was clear in group 2 in a form of generalized necrosis, fatty change and congestion, beside high elevation of serum enzymes (AST, ALT, and ALP). Giving camel's milk and urine mixture to group 5 with ethanol 10% (0.5 g/100g), resulted in significant reduction of levels of serum enzymes (AST, ALT, and ALP) and in stabilization of serum metabolites (total protein, albumin and bilirubin). The degree of reduction was lower when significantly compared to (Silymarin + ethanol) group, and all results were verified by the histopathological changes. Hepatoprotective effects of camel's milk and urine mixture were recorded and this could be attributed to antioxidant activity or to its chelate effects on toxicants. Drinking raw camel milk and urine mixture,

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Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family

Cited by 74 publications

References 13 publications

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Hepatoprotective and antioxidant activities of <i>Hibiscus sabdariffa</i> petal extracts in Wistar rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

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Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family

Cited by 74 publications

References 13 publications

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Hepatoprotective and antioxidant activities of &lt;i&gt;Hibiscus sabdariffa&lt;/i&gt; petal extracts in Wistar rats

Protective Activity of Camel’s Milk and Urine Mixture (&lt;i&gt;Camelus dromedaries&lt;/i&gt;) against Ethanol-Induced Hepatotoxicity in Rats

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Hepatoprotective and antioxidant activities of <i>Hibiscus sabdariffa</i> petal extracts in Wistar rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats