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The present study was undertaken to investigate the effect of the ethanolic extract of Syzygium aromaticum to albino rats. Forty eight Albino rats were employed to test the safety and the anti-inflammatory effect of the extract. Safety of the extract was examined on experimental animal's model at three dose levels of the extract orally in daily doses for three weeks. Effects of S. aromaticum on rats revealed no significant effect on biochemical or haematological parameters. The anti-inflammatory effect of the extract was tested in four equal groups; groups 1 and 2 were treated with 250 and 500 mg/kg of the extract, respectively, group 3 was treated with indomethacine and group 4 was the untreated control. Carrageenan was used as an acute form inducer of inflammation. Indomethacine, the non-steroidal anti-inflammatory drugs (NSAIDs), was used as a reference compound. Oedema size was monitored at the 1 st , 2 nd , 4 th , 6 th and after 24 hours. The ethanolic extract of S. aromaticum showed significant (P < 0.001) decreased in the oedema size at efficacy rates of 79.41%, 82.39% and 63.92% for the dose, 500 mg/kg body weight at the 2 nd , 4 th and 6 th hour respectively higher than that produced by indomethacine.

Seven-day-old male Brown H i s e x chicks were fed Ricinus communis seed at concentrations of 0.5% and 5%.Mortality rates, signs, pathological changes and alterations in clinical chemistry were recorded. The results indicated that both diets containing Ricinus seed are fatal to chicks and that toxicity is characterized by locomotor disturbances, impaired vision, abnormal posture, growth depression, enterohepatonephropathies and anaemia. Significant increases in serum sorbitol dehydrogenase (SDH), glutamic dehydrogenase (GDH), glutamic oxaloacetic transaminase (GOT), potassium, and total hepatic and cardiac lipids, and decreases in hepatic vitamin A, serum total protein and manganese concentrations were observed in Ricinus-fed chicks.

We present the first reported study of Ruta graveolens toxicity in 7-8-month-old Nubian goats. Oral administration of 5 g/kg bw per day of R. graveolens leaves caused tremor, dyspnoea, frequent urination, incoordination of movement, ataxia and recumbency, with death after 1-7 days. In goats receiving oral doses of 1 g/kg bw per day of the leaves, the course of toxicity was prolonged and the animals had pallor of the visible mucous membranes and loss in condition; one died on day 17, the others being slaughtered on days 41 and 46. The clinical effects were correlated with pathological changes in various organs, alterations in serum aspartate transaminase, creatine kinase, total protein, cholesterol, urea and other serum constituents, haematological values and the concentrations in the tissues of copper, iron, zinc, manganese, calcium and phosphorus.

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