Hepatoprotective activity of Woodfordia fruticosa Kurz flowers against carbon tetrachloride induced hepatotoxicity

Chandan, B. K.; Saxena, Ajit Kumar; Shukla, Sangeeta; Sharma, Neha; Gupta, D.K.; Singh, Kuldip; Suri, Jyotsna; Bhadauria, Monika; Qazi, Ghulam N.

doi:10.1016/j.jep.2008.06.020

Cited by 51 publications

(30 citation statements)

References 22 publications

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“…Treatment with HE at the doses of 250 and 500 mg/kg body weight conferred marked protection against APAP-induced liver damage, which effect similar to that of the standard drug silymarin (positive control, group 9). The doses used in this study are in agreement with literature data (Chandan et al, 2008;Olaleye et al, 2010). 328.13 ± 14.9** 276.82 ± 9.78** * p < 0.05 significantly different from control group.…”

Section: Resultssupporting

confidence: 91%

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lucarini

Bernardes

Tozatti

et al. 2014

Emir. J. Food Agric

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The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and its constituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liver damage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg, p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg body weight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These observations were comparable to the normal group prior to APAP administration. Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained results from the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayed significant hepatoprotective activity against APAP-induced liver damage.

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Section: Resultssupporting

confidence: 91%

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lucarini

Bernardes

Tozatti

et al. 2014

Emir. J. Food Agric

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“…Fractionation: The methanolic extract of plant was dispersed in 1 L of distilled water separately and fractionated [8] with toluene, ethylacetate, 2-butanone, n-butyl alcohol and petroleum ether in succession.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats

Sabbani¹,

Ch²,

Thatipelli³

et al. 2015

J Drug Metab Toxicol

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The hepatoprotective and antioxidant activity of methanolic extract of whole plant of Gardenia Gummifera (GGME) was evaluated against paracetamol induced liver damage in rats. And the GGME fractionated based on polarity of solvents with toluene, ethanol, 2-butanone, n-butanol and petroleum ether. The substantially elevated serum enzymatic levels of Aspartate Aminotransferas (AST), Alanine Transaminase (ALT), Alkaline Phosphate (ALP) and total bilirubin were restored towards normalization significantly by the GGME in a dose dependent manner in paracetamol induced liver damage. The biochemical observations were supplemented with histopathological examination liver sections high protection against paracetamol induced hepatoxicity. Further investigation continued with GGME fractions, 2-Butanone Fraction (BTF) and nbutanol Fraction (BAF) substantially elevated serum enzymatic levels of AST, ALT, ALP and Total Bilirubin (TB) were restored towards normalization significantly The significant values showed with n-butanol fraction on pentobarbitone induced sleeping time in mice and the liver weight of paracetamol induced liver damaged in rats. Meanwhile, in vitro antioxidant activities such as DPPH scavenging assay was also screened which were also found significantly positive in a dose dependent manner. The results of this study strongly indicate that GGME and n-butanol fraction results potent hepatoprotective activity against paracetamol induced liver damage in experimental animals.

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“…Sub fraction [6][7][8][9][10][11][12][13][14] 3 :MeOH with increasing contents of methanol afforded compound 8 (45 mg) and 9 (32 mg). Fraction E was subjected to CC over silica gel using gradient elution with C 6 H 6 :EtOAc (10:0-3:7) afforded 24 subfraction (each 15 ml) possess mixture of compounds; subfraction [2][3][4][5][6][7][8][9] subjected to a preparative silica gel chromatography afforded compound 3 (27 mg), then subfractions [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] was re-purified on Sephadex LH-20 CC and eluted with MeOH:H 2 O (9.5:0.5) affording compound 10 (36 mg).…”

Section: Extraction and Isolationmentioning

confidence: 99%

Assessing the Bioactivity and Antioxidative Properties of Some Compounds Isolated From Abutilon Hirtum (Lam.)

Hamed¹,

Refahy²,

Abdel‐Aziz³

2017

Asian J Pharm Clin Res

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Objectives: The present study on the methanol extract of Abutilon hirtum (Lam.) [Malvaceae] afforded ten compounds. Findings from this assessment indicated that A. hirtum leaves possessed vast potential as medicinal product especially in liver cancer treatment.Methods: Dried-powdered leaves were boiled under reflux in 10 L of petroleum ether for 8 hrs. After filtration, the solvent was evaporated; afforded 15 g of petroleum ether extract followed by boiling with reflux for 8 hrs with chloroform, then filtration and the residue was evaporated to give 34 g chloroform extract. Ethyl acetate was added and refluxed for 8 hrs, then filtration and evaporation to give 31 g ethyl acetate extract. Finally the leaves were refluxed with 10 L of 85 % aqueous MeOH, after cooling, the solution was filtered and evaporated and the residue was 210 g methanol extract then the residue was dissolved in de-ionized water (250 ml), then the salt was removed by adding excess methanol solution (2.5 L), and finally filtered. The cytotoxicity of the isolated compounds was evaluated towards HepG2 liver-carcinoma cell line using MTT assay, the antimicrobial activity was tested using the Disc agar plate method and the total antioxidant capacity was determined according to phosphomolybdenum method. Results:The isolated compounds identified as methyl gallate, cuneataside E, bergapten, gallic acid, ellagic acid, epigallocatechin-3-O-gallate, kaempferol-3-O-α-L-rhamnoside, benzyl-1-O-β-D-glucopyranoside, 2(4-hydroxyphenyl)ethyl-O-β-D-glucopyranoside and β-sitosterol. All the isolated compounds are known; but they were isolated from Abutilon hirtum for the first time. Conclusion:This report may serve as a footprint concerning the biological and pharmacological activities of A. hirtum leaves.

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Hepatoprotective activity of Woodfordia fruticosa Kurz flowers against carbon tetrachloride induced hepatotoxicity

Cited by 51 publications

References 22 publications

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats

Assessing the Bioactivity and Antioxidative Properties of Some Compounds Isolated From Abutilon Hirtum (Lam.)

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