Hepatoprotective and Antioxidant Activity of Canscora Perfoliata Lam (Gentianaceae) Against Ccl4 Induced Hepatotoxicity in Rats

Abstract

The aim of the study was to investigate the hepatoprotective activity of ethanol extract of whole plant of Canscora perfoliata in CCl4 induced hepatotoxic rats. Administration of hepatotoxins (CCl4) showed significant elevation of serum SGOT, SGPT, ALP, bilirubin, conjugated, unconjugated bilirubin and lipid peroxidation. Treatment with Canscora perfoliata (150 and 300mg/kg) significantly reduced the above mentioned parameters. The plant extract also enhanced the antioxidant activity. The ethanol extract of Canscora perfoliata have significant effect on the CCl4 induced hepatotoxicity animal models.

Hepatoprotective and antioxidant effect of Polygala chinensis L. whole plant against CCl4 induced hepatotoxicity in rats

“…This might lead to decreased antioxidant defense and increased oxidative stress and thereby the tissue injury occurs. Similar studies also indicate the failure of cellular antioxidant defense system during hepatotoxicity was recorded 32,33 .…”

“…pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP), total, conjugated bilirubin, unconjugated bilirubin were determined as per the standard procedures 12,13 . Liver homogenates (10%W/V) were prepared in ice cold 10mM tris buffer (pH7.4).…”

Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride

“…Tricholoromethyl radical bind covalently with protein, fat and DNA and CCl 3 O 2 will accumulate in reticulum endoplasmic. Increase of CCl 3 and CCl 3 O 2 levels in hepatocyte initiate the lipid peroxidation reaction in phospholipid that composes the cell membran of hepatocyte, and lead to cell membrane dysfunction (Thangakrishnakumari et al, 2017). Free radical that comes from Fenton reaction will also increase.…”

Hepatoprotective activity of whole Plant Extract of Catharanthus Pusillus (Murr.) G.Don (Apocynaceae)

“…Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP), total, conjugated bilirubin, unconjugated bilirubin were determined as per the standard procedures (Shanmugasundaram et al,2010 &Thangakrishnakumari et al, 2012) . Liver homogenates (10%W/V) were prepared in ice cold 10mM tris buffer (pH7.4).…”