The aim of the study was to investigate the hepatoprotective activity of ethanol extract of whole plant of Canscora perfoliata in CCl4 induced hepatotoxic rats. Administration of hepatotoxins (CCl4) showed significant elevation of serum SGOT, SGPT, ALP, bilirubin, conjugated, unconjugated bilirubin and lipid peroxidation. Treatment with Canscora perfoliata (150 and 300mg/kg) significantly reduced the above mentioned parameters. The plant extract also enhanced the antioxidant activity. The ethanol extract of Canscora perfoliata have significant effect on the CCl4 induced hepatotoxicity animal models.