Hepatoprotective, antixidant and anticancer activities of &lt;i&gt; Terminalia brownii&lt;/i&gt; Fresen leaf abstract

Sintayehu, Biruk; Kakoti, Bibhuti Bhusan; Kataki, Manjir Sarma; Gebrelibanos, Mebrahtom; Gomathi, P.; Ayualem, Abadi; Zaru, Hailemichael; Asres, Kaleb

doi:10.4314/epj.v33i1.3

Cited by 3 publications

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“…Our finding that the leaves of T. brownii are rich in antioxidant compounds is in agreement with a previous report that T. brownii leaves contain antioxidant compounds [58,59]. These results warrant further consideration to quantify the antioxidant capacity of the pure compounds in relation to a combination of compounds (fractions and extracts) per one TLC spot.…”

Section: Antioxidant Potential Of a Terminalia Brownii Ethyl Acetate ...supporting

confidence: 92%

Anti-Candida Activity of Extracts Containing Ellagitannins, Triterpenes and Flavonoids of Terminalia brownii, a Medicinal Plant Growing in Semi-Arid and Savannah Woodland in Sudan

et al. 2022

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Various parts of Terminalia brownii (Fresen) are used in Sudanese traditional medicine against fungal infections. The present study aimed to verify these uses by investigating the anti-Candida activity and phytochemistry of T. brownii extracts. Established agar diffusion and microplate dilution methods were used for the antifungal screenings. HPLC-DAD and UHPLC/QTOF-MS were used for the chemical fingerprinting of extracts and for determination of molecular masses. Large inhibition zones and MIC values of 312 µg/mL were obtained with acetone, ethyl acetate and methanol extracts of the leaves and acetone and methanol extracts of the roots. In addition, decoctions and macerations of the leaves and stem bark showed good activity. Sixty compounds were identified from a leaf ethyl acetate extract, showing good antifungal activity. Di-, tri- and tetra-gallotannins, chebulinic acid (eutannin) and ellagitannins, including an isomer of methyl-(S)-flavogallonate, terflavin B and corilagin, were detected in T. brownii leaves for the first time. In addition, genipin, luteolin-7-O-glucoside, apigenin, kaempferol-4’-sulfate, myricetin-3-rhamnoside and sericic acid were also characterized. Amongst the pure compounds present in T. brownii leaves, apigenin and β-sitosterol gave the strongest growth inhibitory effects. From this study, it was evident that the leaf extracts of T. brownii have considerable anti-Candida activity with MIC values ranging from 312 to 2500 µg/mL.

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Section: Antioxidant Potential Of a Terminalia Brownii Ethyl Acetate ...supporting

confidence: 92%

Anti-Candida Activity of Extracts Containing Ellagitannins, Triterpenes and Flavonoids of Terminalia brownii, a Medicinal Plant Growing in Semi-Arid and Savannah Woodland in Sudan

et al. 2022

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“…Te plant is used in traditional medicine for managing various ailments, including yellow fever, diabetes, kidney disorders, diarrhea, rheumatism, gastric ulcers, allergy, wounds, back pain, stomachache, fever, malaria, and cough bronchitis, among others [32]. Terminalia brownii has a wide array of biological activities, including anticancer, antimalarial, antipyretic, antinociceptive, preneoplastic lesion prevention, antidiabetic, and antimycobacterial, among others [33][34][35][36][37][38][39]. Despite T. brownii being widely used in folklore medicine and its immense biological activities, its efect on innate immunity remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

Mbiri

Ogila

Kisangau

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Terminalia brownii is widely used in folklore medicine and has diverse biological activities. However, its effect on the immune system is yet to be studied. Therefore, our study evaluated the immunomodulatory effect of T. brownii on nonspecific immunity. Innate immunity is the initial defence phase against pathogens or injuries. Dichloromethane plant extracts were tested on female Swiss albino mice and Wister rats. The effect of the extract on innate immunity was assessed via total and differential leukocyte counts, tumor necrosis factor-alpha, and nitric oxide production by mouse macrophages. The 3-(4, 5-dimethyl thiazolyl-2)-2, 5-diphenyltetrazolium bromide assay was employed for viability testing. Phytochemical profiling was carried out using gas chromatography-mass spectrometry, while toxicity studies were carried out following the Organization for Economic Cooperation and Development guidelines. Our results demonstrated that administration of T. brownii stem bark dichloromethane extract to pyrogallol-immuno compromised mice significantly ( p < 0.05 ) increased total and differential leukocyte counts compared with the control. The extract showed no adverse effect on the viability of Vero cells and macrophages and significantly ( p < 0.05 ) augmented tumor necrosis factor-alpha and nitric oxide production. Hexadecanoic acid, linoleic acid, octadecanoic acid, squalene, campesterol, stigmasterol, and β-sitosterol, all of which stimulate, were identified in the extract. The extract did not cause any death or toxic signs in rats. In conclusion, T. brownii dichloromethane extract has an immunoenhancing effect on innate immune responses and is not toxic. The observed immunoenhancing impact of the extract was attributed to the presence of the identified compounds. The results of this study provide crucial ethnopharmacological leads towards the development of novel immunomodulators for managing immune-related disorders.

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Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Tola

Ibrahim

Melak

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. MetS are common throughout the world, including Ethiopia. These have traditionally been treated using medicinal plants, particularly in rural areas where they are freely accessible. This systematic review tried to investigate the treatment of MetS with Ethiopian medicinal herbs and made recommendations for more validation research. A careful analysis of the literature was also conducted on the therapeutic effects of these and other Ethiopian medicinal plants with hepatoprotective and antihypertensive activities. Methods. The relevant keywords “Ethnomedicinal + hypertension,” “Ethnopharmacological + hypertension,” “Ethnomedicinal + hepatitis, jaundices, and liver disease,” “Ethnopharmacological + hepatic disorder,” and “Ethnomedicinal + weight loss” were used to search for relevant articles in the major electronic scientific databases, including PubMed, Science Direct, Web of Science, and Google Scholar. The search strategy included all articles with descriptions that were accessible until April 30, 2022. The study’s subjects, methods, or year of publication were no restrictions in the search. The outcomes were compiled using descriptive statistics. Results. Fifty-four (54) studies were examined in the review that satisfied the inclusion and exclusion criteria for the treatment of MetS in Ethiopia. The most often used ethnobotanical plant species for the treatment of hypertension and hepatic disorders were Moringa stenopetala and Croton macrostachyus. Both hepatic and hypertensive disorders were treated more frequently with leaves (52% and 39%, respectively) than with roots (20% and 13%, respectively). Some intriguing studies came from an ethnobotanical investigation into medicinal herbs’ hepatoprotective and antihypertensive properties. The most often investigated medicinal plant for its antihypertensive effects is Moringa stenopetala. Conclusion. The study revealed that Ethiopians often use anti-MetS herbal remedies. We advocate the experimental validation of the commonly used medicinal plants with the identification of active compounds and the development of effective alternative drugs for the treatment of MetS.

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Hepatoprotective, antixidant and anticancer activities of <i> Terminalia brownii</i> Fresen leaf abstract

Cited by 3 publications

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Anti-Candida Activity of Extracts Containing Ellagitannins, Triterpenes and Flavonoids of Terminalia brownii, a Medicinal Plant Growing in Semi-Arid and Savannah Woodland in Sudan

Anti-Candida Activity of Extracts Containing Ellagitannins, Triterpenes and Flavonoids of Terminalia brownii, a Medicinal Plant Growing in Semi-Arid and Savannah Woodland in Sudan

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

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