Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats

Baxla, Sushma Lalita; Gora, Ravuri Halley; Kerketta, Priscilla; Kumar, Nitin; Roy, B. K.; Patra, Pabitra Hriday

doi:10.14202/vetworld.2013.664-667

Cited by 15 publications

(11 citation statements)

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“…Histopathological results demonstrating structural changes in liver tissue of aminoglycoside metal toxic such as lead acetate were reported by some researchers. [ 25 26 ] In the present study, histopathological view of liver sections in lead acetate-treated group showed loss of the normal structure of hepatic cells, blood congestion, and fatty degeneration. Lead acetate thus had deleterious effect on liver tissues.…”

Section: Discussionsupporting

confidence: 53%

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

et al. 2017

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Background:Lead is one of the most toxic metals, producing severe organ damage in animals and humans. Oxidative stress is reported to play an important role in lead acetate-induced liver injury.Aim:This study was carried out to investigate the role of ethanol extract of Eucheuma cottonii in protecting against lead acetate-induced hepatotoxicity in male mice.Materials and Methods:The sample used fifty male mice which were divided into five groups: negative control (mice were given daily with Aquadest); positive control (mice were given daily with lead acetate 20 mg/kg body weight (BW) orally once in a day for 21 days); and the treatment group (mice were given E. cottonii extracts 200 mg, 400 mg, and 800 mg/kg BW orally once in a day for 25 days, and on the 4th day, were given lead acetate 20 mg/kg BW 1 h after E. cottonii extract administration for 21 days). On day 25, the levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured. The data of SGOT, SGPT, ALP, MDA, SOD, and GPx were analyzed with one-way ANOVA, followed by least significant difference test.Results:The results showed that oral administration of lead acetate 20 mg/kg BW for 21 days resulted in a significant increase in SGOT, SGPT, ALP, and MDA levels. Moreover, there was a significant decrease in SOD and GPx levels. Treatment with E. cottonii extracts of 800 mg/kg BW but not with 200 mg/kg BW and 400 mg/kg BW significantly (P < 0.05) decreased the elevated SGPT, SGOT, ALP, and MDA levels as compared to positive control group. Treatment with E. cottonii extracts of 800 mg/kg BW also showed a significant increase in SOD and GPx levels as compared to positive control group. Treating mice with lead acetate showed different histopathological changes such as loss of the normal structure of hepatic cells, blood congestion, and fatty degeneration whereas animals treated with lead acetate and E. cottonii extracts showed an improvement in these changes and the tissue appeared with normal structures.Conclusion:It can be concluded that E. cottonii extracts could be a potent natural product and can provide a promising hepatoprotective effect against lead acetate-induced hepatotoxicity in mice.SUMMARY In summary, Oxidative stress reported to play an important role in lead acetate induced liver injury. The lead acetate treatment significantly increased the SGOT, SGPT, ALP, MDA, and decreased the antioxidant enzymes (SOD and GPx) in liver. The inhibition of antioxidant enzymes will increase free radicals in liver tissues and might induce liver injury in mice. The presence of ethanol extract of Eucheuma cottonii with lead acetate showed protective effects as attenuating lead acetate against its liver toxicity, and this may be due to the activity of ethanol extract of Eucheuma cottonii as antioxidant. The antioxidant enzymes (SOD and GPx) were increased, and MDA, SGOT, SGPT, ALP were decreased after ...

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Section: Discussionsupporting

confidence: 53%

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

et al. 2017

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“…En el caso de los grupos experimentales de C. longa 100 mg y 200 mg/kg/día, se observó una disminución significativa de la actividad enzimática de AST, ALT y ALP. Similares resultados fueron encontrados en estudios previos donde C. longa disminuye el aumento de las enzimas de AST, ALT y APL en hepatotoxicidad inducida con CCl 4 (25)(26)(27)(28)(29) . Además, los resultados obtenidos en la determinación del efecto antioxidante in vitro del extracto de C. longa, explicarían, en parte, la efectividad hepatoprotectora del extracto contra el estrés hepático agudo causado por el CCl 4 , puesto que, el poder reductor de un compuesto sirve como potencial indicador de su capacidad antioxidante (30) .…”

Section: Discussionunclassified

Análisis fitoquímico, actividad antioxidante y hepatoprotectora del extracto acuoso liofilizado de Curcuma longa en lesiones hepáticas inducidas con tetraclorometano en ratas albinas

Canelo-Saldaña

Mendoza-Gardini

Villacrés-Vallejo

et al. 2017

Rev. per. med. integr.

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765REV PERU MED INTEGRATIVA.2017;2(3):765-72. Citar comoCanelo-Saldaña P, Mendoza-Gardini Y, Villacrés Vallejo J, Aranda-Ventura J, González-Aspajo G. Análisis fitoquímico, actividad antioxidante y hepatoprotector del extracto acuoso liofilizado de Curcuma longa en lesiones hepáticas inducidas con tetraclorometano, en ratas albinas Rev Peru Med Integrativa.2017;2(3):765-72. Historia del artículo Información del artículo ResumenObjetivos. Realizar un análisis fitoquímico y describir la actividad hepatoprotectora y antioxidante del extracto de rizomas de Curcuma longa L. (C. longa) en un modelo murino. Materiales y métodos. La actividad antioxidante in vitro del extracto acuoso liofilizado de rizoma de C. longa L. (Fam: Zingiberaceae) se evaluó con el método de DPPH, además, también se realizó el análisis fitoquímico de tres solventes de extracción (ExEt, ExDCM y ExH 2 O). El ensayo in vivo se realizó en ratas albinas cepa Holtzman. Se formaron cinco grupos de tratamiento: (control normal); (control-CCl 4 ); (Control positivo); (C. longa 100 mg/kg) y (C. longa 200 mg/kg), que fueron inducidos con CCl 4 para desarrollar daño hepático. Este modelo permitió medir el efecto protector de los extractos sobre los marcadores bioquímicos (AST, ALT y ALP) en sangre. Posteriormente, se realizó un examen histopatológico de las secciones hepáticas para apoyar la inducción de la hepatoxicidad y la eficacia hepatoprotectora. Resultados.El extracto mostró un poder reductor mucho menor que el ácido ascórbico, en el tamizaje fitoquímico se encontraron compuestos fenólicos, triterpenos, quinonas, cumarinas y flavonoides, además la cantidad de curcumina encontrada fue de 0,4%-0,6%. El extracto liofilizado de C.longa mostró un efecto protector significativo (P<0,05), disminuyendo la actividad enzimática de los marcadores hepatoespecíficos. Los niveles elevados de enzimas séricas AST, ALT y ALP, se hallaron restablecidas hacia la normalización, de manera dosis dependiente, con el máximo efecto protector a dosis de 200 mg/kg. Las observaciones histopatológicas soportan las evidencias bioquímicas de hepatoprotección. Estos efectos fueron comparables a la droga estándar, silimarina. Conclusiones. Los resultados presentados en este estudio revelan fuertemente el efecto protector del extracto liofilizado de C. longa, cultivada en la región Loreto, frente a daño hepático inducido por CCl 4 en experimentación animal. Palabras clave: Curcuma, Antioxidantes, Curcumina, Tetracloruro de Carbono, Hepatoprotector (Fuente: DeCS).Phytochemical analysis, antioxidant and hepatoprotective activity of liofilizated aqueous extract of Curcuma longa on albino rats liver injury induced by tetrachloromethane AbstractObjectives. To develop a phytochemical analysis and describe the hepatoprotective and antioxidant activities of Curcuma longa (C. longa) rhizomes extract in a murine model. Materials and methods. In vitro antioxidant activity of aqueous liofilizated extract of rhizome of C. longa L. (Fam: Zingiberaceae) was evaluated by DPPH assays, and the phyto...

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“…C. longa exerted hepatoprotective properties against liver injury induced by heavy metals, such as lead [40] and mercury [41], and toxic pesticides, such as carbofuran [42] and endosulfan [43], by lowering the serum levels of AST, ALT, ALP, gamma-glutamyl transpeptidase (GGT), and TB, improving hepatic protein synthesis, and preventing toxicity-induced weight loss in rats and chickens. Specifically, oral supplementation of C. longa (500 mg/kg daily for 28 days) led to a significant reduction of the elevated AST, ALT, and ALP in Wistar albino rats, which are abnormal markers associated with the hepatocellular damage.…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review

Jang

Lee

2020

Evidence-Based Complementary and Alternative Medicine

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Hepatobiliary disease currently serves as an important public health issue due to the fact that it is one of the major causes of death among economically active individuals and can easily progress to chronic diseases. Despite the development of vaccines and numerous drugs, a definite treatment remains lacking owing to different stages of the disease itself, its intricate pathogenesis, an effect uncertainty for long-term use, resistance, and side effects. Curcuma longa (C. longa), which belongs to the family Zingiberaceae and the genus Curcuma, has long been used not only as spice for curry or dye but also as a constituent of herbal formula for the treatment of different diseases due to its bioactive activities. Recently, many studies on the experimental results of C. longa have been published relative to hepatobiliary diseases such as fatty liver, hepatitis, cirrhosis, and tumors. Therefore, in this review, we aimed to summarize the pharmacological effects and underlying molecular mechanisms of C. longa and its four compounds, β-elemene, germacrone, ar-turmerone, and bisacurone, against hepatobiliary diseases. C. longa exhibited antioxidant, hepatoprotective, antisteatotic, anti-inflammatory, antifibrotic, antitumor, and cholagogic effects by regulating apoptosis, CYP2E1, Nrf, lipid metabolism-related factors, TGF-β, NF-κB, CYP7A1, and so on. In particular, β-elemene could be an attractive compound owing to its remarkable hepatoprotective, anti-inflammatory, antifibrotic, and antitumor activities. Altogether, the present review provides a preclinical basis for the efficacy of C. longa as an effective therapeutic agent for the prevention and treatment of hepatobiliary diseases, despite the need for further studies to establish the extraction conditions and separation of active constituents with high bioavailability, and warrants further evaluation in clinical trials.

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Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats

Cited by 15 publications

References 31 publications

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

Análisis fitoquímico, actividad antioxidante y hepatoprotectora del extracto acuoso liofilizado de Curcuma longa en lesiones hepáticas inducidas con tetraclorometano en ratas albinas

Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review

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Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats

Cited by 15 publications

References 31 publications

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

The potency of red seaweed (Eucheuma cottonii) extracts as hepatoprotector on lead acetate-induced hepatotoxicity in mice

Análisis fitoquí­mico, actividad antioxidante y hepatoprotectora del extracto acuoso liofilizado de Curcuma longa en lesiones hepáticas inducidas con tetraclorometano en ratas albinas

Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review

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Análisis fitoquímico, actividad antioxidante y hepatoprotectora del extracto acuoso liofilizado de Curcuma longa en lesiones hepáticas inducidas con tetraclorometano en ratas albinas