Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats

Rajasekaran, A.; Periyasamy, Muthusamy

doi:10.1186/1749-8546-7-12

Cited by 22 publications

(20 citation statements)

References 21 publications

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“…These cytosolic enzymes are secreted into the blood due to damage in liver cells. These enzymes are typical of hepatocellular damage and considered as a biomarker in diagnosis and treatment [47,48]. In our study, the serum ALT and AST levels increased statistically significantly in the PARA-treated rats in 6 hr, and this increase is further exacerbated for 24 hr.…”

Section: Discussionsupporting

confidence: 54%

The Role of Urotensin Receptors in the Paracetamol‐Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist

Palabıyık

Karakuş

Akpınar

et al. 2015

Basic Clin Pharma Tox

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We aimed to evaluate the possible protective effect of a UTR antagonist and to determine the effect of the antagonist on ALT and AST levels in serum, the mRNA expression level of UTR, tumour necrosis factor-alpha (TNF-a) and IL-1b and SOD activity, GSH and MDA levels in liver tissues, which are important mediators or markers for the hepatotoxicity animal model in mice. Animals fasted overnight and were divided into seven equal groups (n = 12). The first group was the healthy group (administered 0.1% DMSO intraperitoneally). Group 2 received only paracetamol (PARA) (administered orally at a dosage of 300 mg/kg). Groups 3 and 4 were treated with only AGO (AC7954, UTR agonist) 15 and 30 mg/kg intraperitoneally, respectively. Groups 5 and 6 were treated with only ANTA (SB657510, UTR antagonist) 30 and 60 mg/kg intraperitoneally, respectively. Group 7 was treated with AGO 30 mg/kg and ANTA 60 mg/kg intraperitoneally. One hour after the pre-treatment drugs were administered, groups 3 through 7 were given PARA. After the experimental period, the mice were killed 6 and 24 hr after PARA was administered. Antagonist administration significantly decreased the ALT and AST levels, while agonist administration did not. In addition, SOD activity and GSH levels increased, and the MDA level decreased with the pre-treatment of two antagonist doses. The increased UTR gene expression through PARA was significantly lower in both doses of the antagonist groups at 24 hr when compared with the agonist and PARA groups. This study showed that UTR antagonists have hepatoprotective and anti-inflammatory effects on high-dose PARA-induced hepatotoxicity in mice.

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Section: Discussionsupporting

confidence: 54%

The Role of Urotensin Receptors in the Paracetamol‐Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist

Palabıyık

Karakuş

Akpınar

et al. 2015

Basic Clin Pharma Tox

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“…4 Experimental models using Pct-induced toxicity have been widely employed to evaluate hepatoprotection of drugs and vegetable compounds. Rajasekaran and Periyasamy 5 studied the effect of Trichosanthes lobata and Kiran et al 6 investigated the effect of Cyathea gigantean. Jothy et al 7 compared Polyalthia longifolia and Cassia spectabilis.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats

et al. 2015

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“…10 Singh BN and Saravanan N evaluated the aqueous extract of P. Indica leaves against carbon tetrachloride induced hepatotoxicity in rats. 11 It showed a decreased in the serum enzymatic level of ALT, AST, ALP, total bilirubin.…”

Section: Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves

Valte¹,

Singh²,

Raleng³

et al. 2018

Int J Basic Clin Pharmacol

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Background: Traditionally, the bark of Pavetta Indica Linn., in decoction or pulverized, is administered, especially to children, to correct visceral obstructions. The decocted leaves are used externally to alleviate the pains caused by hemorrhoids. The root, pulverized and mixed with the ginger and rice-water, is given in dropsy. A local fomentation with the leaves is useful in relieving the pain of piles. Paracetamol (PCM) toxicity generates free radicals and raised serum enzyme levels-SGPT, SGOT, Alkaline Phosphatase and S. Albumin. It causes necrosis, congested vessels, multifocal area of fatty changes nuclear disintegration, sinusoidal dilation, kuffer cell hyperplasia. The reverse is considered as the index of hepatoprotective activity. The present study is being taken up to screen hepatoprotective action of P. Indica Linn.Methods: The acute liver damage in albino rats was induced by per oral administration of a single dose of 2000mg/kg b.w. PCM suspension in 0.5% Carboxy methyl cellulose (CMC) and chronic liver damage by giving the same dose of PCM on the 7th day. The hepatoprotective activity was monitored biochemically by estimating S. transaminase, S. bilirubin and S. Protein on the 8th day of experiment.Results: Ethanol extract of P. Indica inhibited PCM induced liver toxicity in albino rats at 100mg/kg and 200mg/kg b.w as assessed by the biochemical values.Conclusions: Ethanol extract of “P. Indica” exhibited significant hepatoprotective activity.

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Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats

Cited by 22 publications

References 21 publications

The Role of Urotensin Receptors in the Paracetamol‐Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist

The Role of Urotensin Receptors in the Paracetamol‐Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist

Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats

Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves

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