Hepatoprotective Effect of Garlic Homogenate Co-Administered with Anti-Tuberculosis Drugs in RatLiver Enzymes

Nasiru, Adabara U; Hafsat, I. G.; Mohammad, Mariam; Sabo, Angelique

doi:10.7763/ijbbb.2012.v2.131

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Previous studies indicated that garlic homogenates showed hepatoprotective activity in mice treated with Isoniazid. 15 Diallyl sulfides were also reported to have a protective effect, in vivo, on carbon tetrachloride-induced liver injury in mice. 16 Thus, it was expected for the polysulfide mixtures (G1 to G6) to show a hepatoprotective effect against acetaminophen toxicity.…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Diallyl Polysulfides fromAllium sativumas Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents

Oosthuizen

Arbach

Meyer

et al. 2017

Journal of Medicinal Food

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Mycobacterium tuberculosis remains one of the world's deadliest killers, with an annual death rate of ∼1.5 million. The medicinal effects of garlic have been well documented, and natural products have been shown to have antimycobacterial activity. The current study evaluated the efficacy of six Allium sativum L. polysulfide mixtures as antimycobacterial agents together with their cytotoxic, immunomodulatory, and hepatoprotective activities. The microtitre PrestoBlue assay was used to determine the minimum inhibitory concentrations (MIC). Cytotoxicity was evaluated by using peripheral blood mononuclear cells (PBMC). Excreted cytokine levels were determined by utilizing an enzyme-linked immunosorbent assay (ELISA), by exposing isolated PBMCs to varying concentrations of polysulfide mixtures. Human C3A liver cells were utilized in the hepatoprotective study, to assess the protective effect against the toxicity induced by acetaminophen. Samples with higher amounts of diallyl trisulfide (Sample G4) showed the highest antimycobacterial activity, exhibiting an MIC of 2.5 μg/mL against M. tuberculosis H37Rv. Five samples showed moderate toxicity in PBMC, with G1 showing no toxicity. The selective index of G4 was the highest, with a selectivity index close to one. Two samples, G3 and G6 containing higher amounts of diallyl tetrasulfide and lower amounts of diallyl trisulfide, showed >50% hepatoprotection. This is comparable to a hepatoprotective agent, Silymarin, which showed a hepatoprotective effect of 30% at the tested concentration. Diallyl tetrasulfide showed significant antimycobacterial activity. A combination of higher diallyl tetrasulfide and lower diallyl trisulfide was indicative of hepatoprotective activity.

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Section: Hepatoprotective Activitymentioning

confidence: 99%

Diallyl Polysulfides fromAllium sativumas Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents

Oosthuizen

Arbach

Meyer

et al. 2017

Journal of Medicinal Food

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“…The main indicators suggesting the improved condition of liver cells were decreased levels of enzymes: Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) and Aspartate Transaminase (AST) observed after co‐administration of plant extracts with anti‐TB drugs in animal models. Such effect was observed for Garlic ( Alium sativum ) homogenate in rats [48], standardized aqueous onion ( Alium cepa ) extract in rats [49], standardized alcoholic extract from Terminalia chebula fruit containing 0.250% chebuloside in rats [50], sylimarin isolated from milk thistle ( Sylibum marianum ) in rats [51] and in rabbits [52], as well as for nanoparticle‐formulated curcumin which significantly reduced liver lesions induced by INH as confirmed by lowering liver enzyme levels in mice [53]. Decreased levels of liver enzymes suggested the reduction of oxidative stress in liver cells [48].…”

Section: Plant‐based Food Products Used For Reduction Of Side Effects...mentioning

confidence: 90%

Plant‐based Food Products for Antimycobacterial Therapy

Sieniawska

Maciejewska-Turska

Świątek

et al. 2020

eFood

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While Tuberculosis (TB) is an ancient disease, it still remains one of top 10 causes of death globally and also a leading cause of death from an infectious agent, exceeding even Human Immunodeficiency Virus (HIV). Worldwide, an estimated 1.7 billion people are infected with Mycobacterium tuberculosis (Mtb). In 2018, an estimated 10.0 million people became ill with TB and almost 1.5 million of TB patients suffered death. Tuberculosis occurs in every part of the world but eight countries with the highest TB burden (India, China, Indonesia, the Philippines, Pakistan, Nigeria, Bangladesh and South Africa) account for two thirds of the total new TB cases [1]. With early diagnosis and appropriate treatment most of the patients infected with TB can be successfully cured. However, 3.4% of new TB cases and 18% of previously treated cases had Rifampicin-resistant TB (RR-TB) or Multidrug-resistant TB (MDR-TB) which can be treated with significantly lower success rate. According to the latest WHO report the treatment success rate for MDR-TB is 56% globally. In recent years an increase of Extensively Drug-resistant TB (XDR-TB), defined as MDR-TB with additional resistance to at least one of the fluoroquinolones and one of the injectable agents used in MDR-TB treatment

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“…As explained in various studies that garlic has anti-mycobacterium activities. Mycobacterium tuberculosis is the most sensitive and rapidly died (Nasiru et al, 2012;Rao et al, 1946).…”

Section: Effect Of Garlic On Human Stomach: Helicobactermentioning

confidence: 99%

Therapeutic Activities of Garlic Constituent Phytochemicals

Ashfaq

Ali

Haider

et al. 2021

Biol Clin Sci Res J

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Garlic (Allium sativum L.) has medicinal value but also an important dietary component for centuries. It belongs to the family of Liliaceae, which is mostly grown and found in Ethiopia and Africa. Ethiopian garlic has been mostly used in traditional medicines. Inhibitory activity of garlic extract has been reported by various researchers for Lactobacillus acidophilus, Staphyloccocus aureus, Nocardia asteroids, pseudomonas aeruginosa, actinomyces viscosus, veillonella alcaligens bacterial strains. The garlic paste and lime was used for mouth sore, sore throat and also can be used in toothpaste to prevent dental caries. The present review describes the potential of garlic phytochemicals for the improvement of the immune system against diseases in humans.

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Hepatoprotective Effect of Garlic Homogenate Co-Administered with Anti-Tuberculosis Drugs in RatLiver Enzymes

Cited by 5 publications

References 19 publications

Diallyl Polysulfides fromAllium sativumas Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents

Diallyl Polysulfides fromAllium sativumas Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents

Plant‐based Food Products for Antimycobacterial Therapy

Therapeutic Activities of Garlic Constituent Phytochemicals

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