Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

Lee, Chanbin; Kim, Jieun; Wang, Sihyung; Sung, Sumi; Kim, Namgyu; Lee, Hyun‐Hee; Seo, Young-Su; Jung, Youngmi

doi:10.3390/ijms20092369

Cited by 34 publications

(15 citation statements)

References 69 publications

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“…Studies have shown that the biologically active compounds in green tea had antioxidant, hypolipidemic, and anti-inflammatory effects, thereby reducing the risk of NAFLD (26,27). Another tea, Kombucha KT, protected the liver cells from inflammation and fibrosis, which helped restore liver function in NAFLD mice (28). Our research showed a new drink of Citrus maxima cv.…”

Section: Discussionmentioning

confidence: 62%

Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease

Wen¹,

An²,

Li³

et al. 2022

Food & Nutrition Research

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Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease that easily induces hepatitis, cirrhosis, and even liver cancer. The long-term use of NAFLD therapeutic drugs produces toxicity and drug resistance. Therefore, it is necessary to develop high efficiency and low-toxicity active ingredients to alleviate NAFLD. Objective: This study aimed to reveal the role and mechanism of a new functional food CMT in alleviating NAFLD. Results: In the ob/ob fatty liver mice models, the CMT extracts significantly inhibited the weight gain of the mice and reduced the accumulation of white fat. The anatomical and pathological results showed that CMT relieved fatty liver in mice and reduced excessive lipid deposition and inflammatory infiltration. Serological and liver biochemical indicators suggest that CMT reduced dyslipidemia and liver damage caused by fatty liver. CMT obviously activated the adenosine 5′-monophosphate-activated protein kinase (AMPK)/acetyl-coA carboxylase (ACC) and AMPK/fatty acid synthase (FAS) signaling pathways, promoted fat oxidation, and inhibited synthesis. Moreover, CMT regulated the expression of inflammatory factors to relieve hepatitis caused by NAFLD. Conclusion: The study explained the role and mechanism of CMT in alleviating NAFLD and suggested that the active ingredients of CMT might be beneficial in NAFLD therapy.

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Section: Discussionmentioning

confidence: 62%

Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease

Wen¹,

An²,

Li³

et al. 2022

Food & Nutrition Research

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“…In a biological study with mice Lee et al. (2019) induced liver steatosis in animals using a diet low in methionine and applied the supplementation of kombucha fermented from black tea, which was able to prevent vacuolization when compared to the group that did not receive this supplementation.…”

Section: Resultsmentioning

confidence: 99%

Effects of supplementation with kombucha and green banana flour on Wistar rats fed with a cafeteria diet

Urrutia

Ramos

Menegusso

et al. 2021

Heliyon

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Introduction With the increase of chronic diseases as a consequence of the population's eating habits, there is also a growing interest in foods rich in bioactive compounds capable of mitigating these diseases. Thus, this study aimed to evaluate the effects of supplementation with kombucha and green banana flour (GBF) on Wistar rats fed with cafeteria diet (CAF). Methods The animals were randomized into five groups of seven animals each, which were fed with the following diets: Treatment 1 (T1): Control treatment/commercial feed; Treatment 2 (T2): cafeteria diet (CAF); Treatment 3 (T3): CAF + kombucha; Treatment 4 (T4): CAF + green banana flour (GBF); Treatment 5 (T5): CAF + GBF + kombucha. Daily weight gain, daily food consumption, feed conversion, blood glucose, total cholesterol and fractions, triglycerides, liver enzymes, antioxidant activity, and body composition were evaluated. Results T5 presented lower feed intake and less weight gain. Liver histology revealed vacuolization in all treatments except T1, which was confirmed by the results of liver enzymes. There was no increase in blood glucose, and changes were observed in the lipid profile of the animals. T1 had the lowest body fat and the highest protein levels. Differences were observed for the antioxidant capacity in the liver of animals among treatments. Conclusion The intake of cafeteria diet altered the lipid and liver profile of the animals and the consumption of kombucha and GBF did not prevent these changes. The high polyphenols level of kombucha did not exert a hepatoprotective effect as an antioxidant. However, this supplementation generated greater satiety in the animals, leading to less weight gain until the end of the experiment.

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“…On the other hand, the hepaprotective efficacy of kombucha has been studied by liver toxicity markers' assessment, such as serum glutamic pyruvate transaminase, assessing the antioxidant enzymes, like superoxide dismutase and catalase, and various levels of creatinine and urea in the liver tissue [25]. Lee and collaborators [33] were able to show the protective characteristic of Kombucha in insulin-resistant mice, improving liver The literature also highlights the high antioxidant potential of Kombucha [21,24,25]. This antioxidant property depends on three important factors: the type and composition of the tea infusion, the SCOBY, and the fermentation process.…”

Section: Kombucha: Concept and Health Benefitsmentioning

confidence: 99%

Kombucha: Perceptions and Future Prospects

Batista

Penas

Pintado

et al. 2022

Foods

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Background: Kombucha is an increasingly consumed product classified as a nutraceutical. Legislative efforts about these products remain confusing and without global harmonization. This natural product has been developed to improve or promote physical and mental health. However, it needs regulatory guidelines to control the production and guarantee the product’s efficacy and safety. Aim: The study intends to draw attention to the need for regulatory guidelines and the potential of this product in the market and peoples’ health. Key findings and conclusions: The lack of regulation and the low level of literacy about this product can limit its development, marketing, and impact on health. Thus, it is essential to highlight the potential value of this product and invest in its development and marketing. Likewise, it is important to spread awareness among the population of these products and their impacts on people’s health. Thus, this study focuses on a pertinent theme and alerts to the need for legislation for these products, to draw attention to the inexistent legislative control and the consequent need for regulatory guidelines for better and safer production and consumption.

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Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

Cited by 34 publications

References 69 publications

Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease

Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease

Effects of supplementation with kombucha and green banana flour on Wistar rats fed with a cafeteria diet

Kombucha: Perceptions and Future Prospects

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