Hepatoprotective effect of the ethanolic extract of Anethum graveolens L. on paracetamol-induced hepatic damage in rats

Thuppia, Amornnat; Jitvaropas, Rungrat; Saenthaweesuk, Suphaket; Somparn, Nuntiya; Kaulpiboon, Jarunee

doi:10.1055/s-0031-1282406

Cited by 6 publications

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“…Nevertheless, in rats treated with dill extract at the doses of 100 and 300 mg/kg, the severity of liver damage was reduced significantly, indicating its potential hepatoprotective properties. Our data were similar to the findings of Thuppia et al [ 30 ], Rabeh and Aboraya [ 31 ], and Tamilarasi et al [ 35 ] and also our previous results [ 36 ] that showed dill oil, dill ethanolic extract, crude powder of dill, and dill tablet have potential antioxidant and hepatoprotective effects on in rats.…”

Section: Discussionsupporting

confidence: 93%

“…Reduction at dose of 300 mg/kg was more significant. Our result was in agreement with Yazdanparast and Bahramikia [ 32 ], Koppula and Choi [ 6 ], Thuppia et al [ 30 ], Hajhashemi and Abbasi [ 33 ], Madani et al [ 5 ], and other studies [ 34 ] as formerly stated that dill significantly reduced blood lipids and liver enzymes.…”

Section: Discussionsupporting

confidence: 93%

“…Serum transferases (ALT and AST) are accepted as sensitive markers, strongly related to liver toxicity and damage [ 27 ]. Thuppia et al [ 30 ] showed that ethanolic extract of dill has a hepatoprotective activity by declining the AST and ALT levels on acetaminophen-induced hepatic damage in rats. In this study treating the rats with dill extracts especially at the dose of 300 mg/kg did cause significant reduction on both ALT and AST levels.…”

Section: Discussionmentioning

confidence: 99%

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Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Oshaghi

Khodadadi

Mirzaei

et al. 2017

Journal of Pharmaceutics

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The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats' liver. Thiol groups' oxidation, amyloid cross-β, and protein fragmentation (P < 0.001) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (P < 0.05). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Oshaghi

Khodadadi

Mirzaei

et al. 2017

Journal of Pharmaceutics

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“…This is in agreement with Thuppia et al ., who reported that administration of ethanolic extract of dill in paracetamol-induced hepatic damage in rats has hepatoprotective properties. [ 11 ] Rabeh et al . also showed that dill or fennel oil and their mixtures have hepatoprotective activities.…”

Section: Discussionmentioning

confidence: 99%

Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat

Oshaghi

Khodadadi

Tavilani

et al. 2016

Int J App Basic Med Res

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Background:Liver damage induced by carbon tetrachloride (CCl4) has been presented as an experimental model for research in hepatoprotective effects of natural product. A commercial medicine prepared from Anethum graveolens L (dill) is being used as dill tablet (DT) as a hypolipidemic agent. This experiment aimed to investigate the protective effect of DT against hepatic damage.Materials and Methods:Male Wistar rats were randomly divided into four groups (n = 6) as following for a 10 days experiments. (1) Normal animals; (2) normal animals +CCl4 1 ml/kg (1:1 of CCl4 in olive oil, by gastric tube); (3) CCl4 treated animals +100 mg DT/kg; (4) CCl4 treated animals +300 mg DT/kg. After 10 days of treatment, biochemical factors were measured; also antioxidant tests such as thiol group, malondialdehyde (MDA), total antioxidant capacity (TAC), and catalase (CAT) activity in the liver samples were carried out.Results:In dill treated animals, a significant decrease in liver enzymes lactate dehydrogenase, alkaline phosphatase, aspartate transaminase, alanine transaminase, γ-glutamyl transferase, total bilirubin, direct bilirubin, as well as triglyceride, total cholesterol (P < 0.05) were observed. Total protein and albumin concentrations were significantly increased in dill treated groups (P < 0.05). Furthermore, treatment with dill declined liver cholesterol, triglyceride, MDA, and increased TAC and CAT activity compared with untreated group (P < 0.05).Conclusion:Dill displayed a potential hepatoprotective effect against CCl4-induced liver damage based on both biochemical markers and antioxidant status.

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“…It is documented that dill decreased total cholesterol without any side effects [104,105,106]. Apart from this, dill has hepatoprotective properties [107,108,109,110,111,112]. Dill exhibited great anti-cancer activity on oral cavities and breast cancer cells lines [113].…”

Section: Anethum Graveolensmentioning

confidence: 99%

Nutraceutical Potential of Apiaceae

Aćimović

2017

Reference Series in Phytochemistry

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Apiaceae family is large, with over 3.000 species worldwide cultivated for many purposes. Some plants in this family such as carrots, parsley, parsnip and celery are common vegetable crops, while other members like anise, caraway, coriander, cumin, fennel, lovage, angelica and dill are famous for their medicinal and aromatic properties. Usage of these plants is very popular in everyday diet because of their documented health benefits. Apiaceae are a very important source of phytochemicalschemicals with biological activity. However, phytochemicals are non-nutritive plant chemicals, also called nutraceuticals. They are widely used for prevention, treatment or cure of conditions or diseases. Bioactive compounds with nutraceutical potential are polyphenolic compounds, polyacetylenes and terpenoids. The aim of this review is to represent selected plants of Apiaceae family currently used as nutraceuticals and describe their nutritional benefits.

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Hepatoprotective effect of the ethanolic extract of Anethum graveolens L. on paracetamol-induced hepatic damage in rats

Cited by 6 publications

References 0 publications

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat

Nutraceutical Potential of Apiaceae

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Hepatoprotective effect of the ethanolic extract of Anethum graveolens L. on paracetamol-induced hepatic damage in rats

Cited by 6 publications

References 0 publications

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4 Induced Liver Toxicity in Rat

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4 Induced Liver Toxicity in Rat

Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat

Nutraceutical Potential of Apiaceae

Contact Info

Product

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Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat