Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats

Wegwu, M. O.; Didia, BC

doi:10.4314/biokem.v19i1.56418

Cited by 4 publications

(5 citation statements)

References 13 publications

(6 reference statements)

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“…This is in agreement with earlier findings of Adedera [50] which states that the seeds of Garcinia kola possess antilipoperoxidative effect, a proof of its antioxidative properties inhibiting lipid peroxidation as seen in the MDA result for groups 3 and 4 (table 3). The reduction in MDA level prior to pretreatment with Garcinia kola is in accordance with the findings of Wegwu [51] which stated that Garcinia kola seed possesses natural antioxidants which can salvage cells from free radical damage.…”

Section: Glutathionesupporting

confidence: 89%

Effect of Combination Therapy of Garcinia kola Seed and Vitamin E in Acetaminophen Induced Hepatotoxicity and Oxidative Stress in Albino Rats

Waribo¹,

Bartimaeus²,

Nduka³

et al. 2019

IJBcRR

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Acetaminophen, used for antipyretic and analgesic purposes has been known to exhibit toxic effects on the organs because of its ability to generate free radicals, causing varieties of diseases. This study investigated the impact of the combined formed of Garcinia kola seed and Vitamin E pretreatment exposure on hepatotoxicity and oxidative stress induced by acetaminophen in Albino Rats. Five groups of animals were used for this study. Group 1 as the control received distilled water orally only, group 2 as toxicity control intoxicated with 800 mg acetaminophen intraperitoneally. The other three groups were pretreated with various doses of either Garcinia kola seed extract or vitamin E or a combined form respectively by oral gavage method for 7 days before induction with acetaminophen intraperitoneally on the 8th day and sacrificed under chloroform anaethesia. Acetaminophen induction significantly rise (p<0.05) the hepatic enzyme levels (ALT, AST, and ALP) and a marked reduction of the antioxidant enzymes (SOD, CAT and GPX) in group 2 animals when compared with the control. There was also a significant rise (p<0.05) in the MDA levels. Meanwhile the combined form of Garcinia kola seed extract and Vitamin E pretreatment exposure on the organs showed no synergetic ameliorative potentials as compared with the single pretreatment exposure with Garcinia kola and Vitamin E respectively. The morphology of the tissue cells pretreated with these combined formed exhibited features showing signs of cell damages and slow recovery from the toxicity. Therefore combining Garcinia kola and Vitamin E may lost its ameliorative and protective effect as seen in this induced acetaminophen albino rats implying that Garcinia kola seed and Vitamin E should not be taken in a combined form.

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Section: Glutathionesupporting

confidence: 89%

Effect of Combination Therapy of Garcinia kola Seed and Vitamin E in Acetaminophen Induced Hepatotoxicity and Oxidative Stress in Albino Rats

Waribo¹,

Bartimaeus²,

Nduka³

et al. 2019

IJBcRR

View full text Add to dashboard Cite

show abstract

“…This is consistent with Raghavendran et al (2004) who reported that free radical intoxication leads to membrane damage. Thus treatment with both extracts caused a dose dependent significant decrease in the MDA concentration of the treatment groups (3, 4, 5, and 6) when compared to the untreated group (2), thus this fit in with the finding of Wegwu and Didia (2007) which suggest that these plant materials may possess the normal antioxidants necessary for protection against free radical damage induced by H 2 O 2 in rats bio-system. Table 2 shows a significant decrease (p< 0.05) in the vitamin C concentration on administration of H 2 O 2 in group 2 rats (untreated group).…”

Section: Resultssupporting

confidence: 79%

“…kola has been found to contain Garcinia biflavonones (GB -1, GB-2), kolaflavonone, benzophenone and xanthones and studies have also shown the ability of these compound in protecting against hepatotoxicity induced by phalloidin, amanita, 2-acetylaminofluorene, carbon tetrachloirde, paracetamol, aflatoxin, dimethyl nitrosamine in rodents (Sanchez et al, 2009). G. kola also possesses other pharmacological properties like: Hepatoprotective effects (Wegwu and Didia, 2007), hypoglycemic and antioxidant properties (Omage et al, 2011), antimicrobial effects (Antwi-Boasiako and Abubakari, 2011), antitrichomonal activity (Ibikunle and Ogbadoyi, 2011), and antioxidative and chemopreventive properties (Farombi and Owoeye, 2011).…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on the possible antioxidant properties of ethanolic seed extracts of Cola nitida (kola nut) and Garcinia kola (bitter kola) on hydrogen peroxide induced oxidative stress in rats

Joshua¹,

Ukegbu²,

Eze³

et al. 2017

J. Med. Plants Res.

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Oxidative stress and impaired antioxidant system have been implicated in the pathophysiology of diverse disease states. This research was done to investigate comparatively the possible enzymatic and non-enzymatic antioxidant properties of ethanol extracts of Cola nitida and Garcinia kola in H 2 O 2challenged rats. Thirty (30) Wistar albino rats were used for this study and were divided into 6 groups of 5 rats per group. Group 1 rats were normal control; group 2 rats were induced with H 2 O 2 only (positive control). Group 3 and 4 were challenged with H 2 O 2 and treated with 100 and 200 mg/kg b.w of ethanol extract of C. nitida, respectively. In the same vein, groups 5 and 6 rats represented H 2 O 2-induced rats treated with 100 and 200 mg/kg b.w of ethanol extract of G. kola seed respectively. Group 2 (positive control group) rats showed a significant increase (p<0.05) in malondialdehyde (MDA) concentration compared to rats in group 1 and the treatment groups. Conversely there was a significant decrease (p<0.05) in glutathione concentration of the group when compared to rats in group 2. Group 2 showed a significant decrease (p<0.05) in vitamin C concentration compared to rats in group 1 and the treatment groups. The effects of extracts were accompanied by a significant increase (p<0.05) in the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) when compared to the group 2 (positive control group). The two extracts exhibited a significant ferric reducing antioxidant properties (FRAP) in a concentration-dependent manner. This finding indicated that the extracts could contain antioxidant and thus have potential for scavenging free radicals, hence arresting oxidative stress. This may justify their local use in management of some hepatic dysfunction and stress related conditions. However, extracts of G. kola was seen to be more potent than that of C. nitida.

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“…Several studies have revealed the protective effects of G. cambogia in liver toxicity. G. cambogia has been reported to offer protection against carbon-tetrachloride induced liver damage (11). A study by Ates et al (12) showed that G. cambogia supplementation resulted in reduced fat infiltration in rats that were fed high lipid diet compared to the group that had high lipid diet without G. cambogia extract.…”

Section: Introductionmentioning

confidence: 99%

<i>Garcinia cambogia</i> ethanolic extract protects the liver from ciprofloxacin-induced hepatoxicity

Ukwenya¹

2019

Research Journal of Health Sciences

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This study investigated the effects of the ethanolic extract of Garcinia cambogia on ciprofloxacin-induced hepatotoxicity. Method: Twenty (20) adult male Wistar rats were divided into four groups; Group A were given ciprofloxacin only (150 mg/kg b.w), Group B were given ciprofloxacin (150 mg/kg b.w) and extract (400 mg/kg b.w) simultaneously, Group C were given extract only (400 mg/kg b.w) and Group D served as control and received 1.5ml of distilled water as placebo. Serum and liver tissue were collected and processed for biochemical and histological studies respectively. Results: The result of this work showed significantly elevated levels of aspartate transaminase (ASP), alkaline phosphatase (ALP) and alanine transaminase (ALT) in ciprofloxacin-treated rats compared to the Garcinia cambogia-treated and control groups. The histological analysis also showed distortion of the lobular architecture and presence of inflammatory cells within the sinusoids and hepatocellular apoptosis in Group A. Conclusion: The results showed that Garcinia cambogia attenuates the toxic effects of ciprofloxacine on the liver.

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Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats

Cited by 4 publications

References 13 publications

Effect of Combination Therapy of Garcinia kola Seed and Vitamin E in Acetaminophen Induced Hepatotoxicity and Oxidative Stress in Albino Rats

Effect of Combination Therapy of Garcinia kola Seed and Vitamin E in Acetaminophen Induced Hepatotoxicity and Oxidative Stress in Albino Rats

Comparative studies on the possible antioxidant properties of ethanolic seed extracts of Cola nitida (kola nut) and Garcinia kola (bitter kola) on hydrogen peroxide induced oxidative stress in rats

<i>Garcinia cambogia</i> ethanolic extract protects the liver from ciprofloxacin-induced hepatoxicity

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