Comparative studies on the possible antioxidant properties of ethanolic seed extracts of Cola nitida (kola nut) and Garcinia kola (bitter kola) on hydrogen peroxide induced oxidative stress in rats

Joshua, P. E.; Ukegbu, Chimere Young; Eze, C. S.; Umeh, B. O.; Oparandu, L. U.; Okafor, J. O.; Nkwocha, Chinelo Chinenye; Ogara, A.

doi:10.5897/jmpr2017.6387

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…By implication, an elevated reducing capacity of these extracts may be significant in counteracting free radicals generated in hyperglycemic condition thus delaying the progress of diabetic complications because of the effect of oxidative stress (Sudha et al,2011). The reducing power result in this study corroborates with the report of Joshua et al (2017).…”

Section: In Vitro Antioxidant Capacity and Alpha Amylase Inhibitory A...supporting

confidence: 85%

Nutrients composition and functional properties of oil palm syrup, aqueous extract of kola nut and their mixtures

Komolafe,

Oboh

2023

J. Agr. Food Sci.

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In this study, oil palm (Elaeis guineensis) syrup, aqueous extracts of kola nut (Cola acuminata) and their mixtures (decoction of C. acuminata in 20 % oil palm syrup solution) were investigated using suitable biochemical procedures. The proximate analysis of oil palm syrup and C. acuminata revealed the values of moisture, crude protein, fat, ash, fibre and nitrogen free extract of oil palm syrup were 29.55 %, 0.50 %, 2.34 %, 2.32 %, 0.00 % and 65.29 % while values for the C. acuminata were 44.70 %, 17.50 %, 2.45 %, 1.91 %, 8.86 % and 24.58 %. Also, the total carbohydrate constituted 66.29 % when determined by anthrone method. The pH and titratable acidity values were within the acidic range. The syrup, C. acuminata and its mixture extracts recorded high reducing power, total phenolic and vitamin C contents. The IC50 values of α-amylase inhibitory activity for aqueous solutions of palm syrup, aqueous extracts of C. acuminata and its mixture extract were 0.51, 4.50 and 12.10 % respectively. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of aqueous solutions of oil palm syrup, aqueous extracts of C. acuminata and its mixture extracts revealed IC50 values of 8.44, 3.29 and 6.60 %. The results of this study suggest that the decoction of C. acuminata in 20 % syrup solution had synergistic effects with respect to in vitro antioxidant properties and alpha amylase inhibitory potential, and further indicates that the studied extracts could elicit potential nutritional and health benefits.

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Section: In Vitro Antioxidant Capacity and Alpha Amylase Inhibitory A...supporting

confidence: 85%

Nutrients composition and functional properties of oil palm syrup, aqueous extract of kola nut and their mixtures

Komolafe,

Oboh

2023

J. Agr. Food Sci.

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“…In this study, the induction of oxidative stress in the hippocampal tissue was observed across all kola nut-treated pups through the increase of MDA concentration. Joshua et al (2017) andErukainure et al (2017) observed a decrease in the MDA levels in the liver of the rats exposed to H2O and treated with kola nut extract. These changes in the MDA levels could be attributed to dose-dependent and tissue-specific differences as a higher dose was used in this study.…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut

Atiba

Nkomozepi

Mbajiorgu

et al. 2023

Preprint

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Kola nut is commonly consumed by pregnant women to suppress symptoms of morning sickness. This study investigated the effects of kola nut on the biochemical indices of the hippocampus and its dependent memory. Kola nut extract was fed to pregnant dams from the first day of their pregnancy until parturition. The following behavioral function tests were conducted: surface righting (SR); cliff avoidance (post-natal day [PND] 4, 5, 6 & 7); open field; novel object recognition and location; and radial-arm maze (PND 21 and 56). The levels of brain-derived neurotrophic factor (BDNF), acetylcholine (ACh), and malondialdehyde (MDA) of the matched hippocampal tissues were also checked in the pups. The kola nut-treated pups showed significantly reduced behavioral indices compared to the pups in the control group: lower postural balance, higher risk avoidance memory, and lower frequency in pivoting and rearing compared to that in the control group. However, the frequency of urine and fecal bolus was significantly lower in the pups in the control group than that in the treated pups. The discrimination ratio of the control group pups in novel object recognition (NOR) and novel object location (NOL) was significantly higher than that in the treated pups, and the time taken by the treated pups to complete RAM was significantly higher. The levels of ACh and BDNF in the treated pups were increased compared to that in control pups. A positive correlation was found between MDA and SR (r = 0.7207; p = 0.0437), grooming (r = 0.7707; p = 0.0252), and fecal bolus (r = 0.7606; p = 0.0284), as well with the BDNF level in those treated with grooming (r = 0.7570; p = 0.0297). However, negative correlations between ACh and rearing (r = -0.8261; p = 0.0115) and fecal bolus (r = -0.8066; p = 0.0156) and a positive correlation with NOL (r = 0.8358; p = 0.0098) were observed. Based on these observations, the study concluded that Kola nut affects both biochemical and hippocampal memory profiles.

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“…In the present study, kola nuts were selected above other types of nuts due to their unique properties. The leaves of C. nitida, with their distinctive bitter taste, are ideal for refreshing the palate, and the twigs are used as sources of alkaloids in medical compositions (Joshua et al, 2017). Leaves, flowers, twigs, fruit follicles, and bark of C. nitida are all used to make a tonic that is said to cure dysentery and other digestive issues associated with characteristics of cough and pain (Okeke et al, 2015;Atawodi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

IN-VITRO NUTRITIONAL, PHYTOCHEMICAL, ANTIOXIDANT AND ANTI-INFLAMMATORY ANALYSES INDICATED DISPARITY IN Cola nitida L. and Garcinia kola Heckel USED IN NIGERIA

Apiamu¹,

Orhonigbe²,

Evuen³

et al. 2023

FJS

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The research affirmed that Cola nitida L. and Garcinia kola Heckel used in Nigeria are quite different medicinally and nutritionally. The proportions of all nutrients analyzed quantitatively (lipid, moisture, fibre, ash, and protein except carbohydrate) were greater in C. nitida than in G. kola Heckel (p<0.05). C. nitida has a lower energy density than G. kola Heckel (332.20 kcal/g vs 349.10 kcal/g sample) (p<0.05). Alkaloids, flavonoids, phenolics, and cardiac glycosides were all significantly greater in G. kola Heckel than C. nitida at p<0.05, in addition to saponin, tannin, and steroids. A 72-hour methanol extraction of kola nuts by cold maceration showed that C. nitida had significantly lower total phenolic, flavonoid, and tannin contents than G. kola Heckel (TPCs: 1815.38±125.90 µg GAE; TFCs: 385.80±37.24 µg QE; and TTCs: 2643.75±36.08 µg TAE/g sample). 2.2-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays showed that G. kola Heckel (IC50 = 133.70 ± 0.11 µg/mL) was more effective than C. nitida (IC50 = 226.70 ± 0.21 µg/mL) at the 0.05 level. Studies on anti-inflammation found similar effects for G. kola Heckel and C. nitida (antiproteinase activity IC50 = 162.90 and 223.60 µg/mL; albumin denaturation: IC50 = 155.10 and 347.20 µg/mL; and membrane stabilization: IC50 = 183.50 and 271.70 µg/mL). Thus, it is proposed here that G. kola Heckel, in comparison to C. nitida, may be an acceptable source of energy, an antioxidant, and an anti-inflammatory agent in the nutraceutical and pharmaceutical sectors for the benefit of humans.

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Comparative studies on the possible antioxidant properties of ethanolic seed extracts of Cola nitida (kola nut) and Garcinia kola (bitter kola) on hydrogen peroxide induced oxidative stress in rats

Cited by 6 publications

References 18 publications

Nutrients composition and functional properties of oil palm syrup, aqueous extract of kola nut and their mixtures

Nutrients composition and functional properties of oil palm syrup, aqueous extract of kola nut and their mixtures

Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut

IN-VITRO NUTRITIONAL, PHYTOCHEMICAL, ANTIOXIDANT AND ANTI-INFLAMMATORY ANALYSES INDICATED DISPARITY IN Cola nitida L. and Garcinia kola Heckel USED IN NIGERIA

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