Hepatoprotective effects of Turkish folk remedies on experimental liver injury

Aktay, Göknur; Deliorman, Didem; Ergun, Ender; Ergün, Fatma; Yeşilada, Erdem; Çevi̇k, Cemal

doi:10.1016/s0378-8741(00)00286-5

Cited by 58 publications

(39 citation statements)

References 9 publications

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“…Artichoke is very beneficial to the liver; recent studies have found that it may even regenerate liver tissue. Studies on artichoke demonstrated its health protective potential, especially their hepatoprotective (Gebhardt, 1997;Aktay et al, 2000) anticarcinogenic (Wang et al, 2003), hypocholesterolemic activities (Lupattelli et al, 2004) and antimicrobial (Zhu et al, 2004). The two major phytonutrients found Int.…”

Section: Introductionmentioning

confidence: 99%

Manufacture of Functional Labneh Using Uf-Retentate and Artichoke Puree

Saad¹,

Salama²,

El‐Sayed³

2015

International J. of Dairy Science

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Artichoke, UF-retentate and Bifidobacteria were used in success to manufacture novel functional labneh treatments in this study. Artichoke (Cynara scolymus L.) puree was added in ratios of 0, 15, 30 and 45% of the formula. Bifidobacterium bifidum, Lactobacillus bulgaricus and Streptococcus thermophilus (1:1) were added to produce lactic acid and healthy compounds. Total solids, fat/dry matter, ash, pH values, Total Nitrogen (TN), Soluble Nitrogen (SN) contents and Total Volatile Fatty Acids (TVFA) were determined. All samples texture profile measurements were also carried out. Streptococcus thermophilus continuously increased in all treatments followed by slight decrease towards the end of the storage period especially with control. Also, Bifidobacterium bifidium numerous increased during storage period to reach up to log 9.00 CFU gG 1 especially in the treatment that contained 30% artichoke puree. Results demonstrated that artichoke is a suitable food carrier that allows the survival of potentially probiotic strains. Preferences of treated samples 15 and 30% artichoke puree were as well as the control especially in outer appearance and flavour.

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Section: Introductionmentioning

confidence: 99%

Manufacture of Functional Labneh Using Uf-Retentate and Artichoke Puree

Saad¹,

Salama²,

El‐Sayed³

2015

International J. of Dairy Science

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“…In general, the dried extract consisting of leaves and not flowering heads of artichoke has been eluted with water in European countries and the main components are caffeoylquinic acid derivatives (cynarin and chlorogenic acid), flavonoids (luteolin and apigenin) and bitters (cynaropicrin). [1][2][3][4] Artichoke leaf extract has been used for hepatoprotective 5,6) and cholesterol reducing 7,8) purposes. Based on in vitro 5,9,10) and in vivo 6,11) studies, it is believed that artichoke leaf extract is very effective as an antioxidant and its beneficial effects are attributed to its antioxidant action.…”

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confidence: 99%

“…[1][2][3][4] Artichoke leaf extract has been used for hepatoprotective 5,6) and cholesterol reducing 7,8) purposes. Based on in vitro 5,9,10) and in vivo 6,11) studies, it is believed that artichoke leaf extract is very effective as an antioxidant and its beneficial effects are attributed to its antioxidant action. However, there is still no experimental evidence indicating which components possess the beneficial effects.…”

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confidence: 99%

Effects of Artichoke Leaf Extract on Acute Gastric Mucosal Injury in Rats

Ishida

Kojima

Tsuboi

et al. 2010

Biological & Pharmaceutical Bulletin

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The present study was designed to clarify the effects of an ethanol extract of artichoke leaf on acute gastric mucosal injury in rats. Oral administration of artichoke leaf extract dose-dependently prevented absolute ethanol-induced (125-500 mg/kg) or restraint plus water immersion stress-induced gastric mucosal injury (1000-2000 mg/kg). The artichoke leaf extract contains 1% cynaropicrin and 0.8% chlorogenic acid as main components and 70% dextrin as a vehicle. Cynaropicrin at doses of 1/100 of artichoke leaf extract [ethanol-induced mucosal injury: 5 mg/kg, per os (p.o.); stress-induced mucosal injury: 20 mg/kg, p.o.] also prevented gastric mucosal injury in both animal models. However, dextrin and chlorogenic acid at doses contained in the leaf extract were ineffective in both models. When artichoke leaf extract was given orally to normal rats, it (500-2000 mg/kg, p.o.) dose-dependently increased gastric mucus content. In addition, it (125-500 mg/kg, p.o.) dosedependently prevented the decrease in gastric mucus content by absolute ethanol. When the effects of artichoke leaf extract on basal gastric acid secretion in rats were evaluated, it (500-2000 mg/kg, p.o.) dose-dependently increased the volume of gastric juice in normal rats. However, it was ineffective in decreasing basal gastric acid secretion in normal rats. These results indicate that artichoke leaf extract is effective against acute gastritis and its beneficial effect is due to that of cynaropicrin. The gastric mucus-increasing action of artichoke leaf extract may be, at least in part, related to the anti-gastritic action of the extract.

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“…This damage to the structural integrity of the liver was observed from elevated serum levels of hepatospecific enzymes, i.e. AST and ALT (Aktay et al, 2000). The second phase is caused by the inflammatory response, which involves activation of Kupffer cells, probably by free radicals.…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Moutan Cortex Radicis against Acute Hepatotoxicity

Park

Kim

Lee

2011

Afr. J. Trad. Compl. Alt. Med.

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This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl 4 )-, D-galactosamine (GalN)-and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl 4 (10 μL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl 4, GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl 4 or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in inflammatory cell infiltration. These changes were inhibited by MCR. Serum total bilirubin concentration increased and bile flow decreased significantly 48 h after ANIT treatment, which was attenuated by MCR. Our results suggest that MCR has a protective effect on acute liver injury.

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Hepatoprotective effects of Turkish folk remedies on experimental liver injury

Cited by 58 publications

References 9 publications

Manufacture of Functional Labneh Using Uf-Retentate and Artichoke Puree

Manufacture of Functional Labneh Using Uf-Retentate and Artichoke Puree

Effects of Artichoke Leaf Extract on Acute Gastric Mucosal Injury in Rats

Protective Effects of Moutan Cortex Radicis against Acute Hepatotoxicity

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