Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice

Nguyen, Vanphuc; Huang, Jianchun; Doan, Vanminh; Lin, Xiaobo; Tang, Xiuneng; Huang, Yuanheng; Ai-cun, Tang; Yang, Xin; Huang, Renbin

doi:10.1016/j.jep.2015.06.048

Cited by 19 publications

(3 citation statements)

References 28 publications

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“…Nimesulide, nonsteroidal anti-inflammatory drug, could increase the activities of ALT, AST, ALP and the content of bilirubin in the serum. The activities of SOD and CAT and GSH-Px in the liver were decreased by nimesulide in mice [ 53 ]. Chronic administration of fluoxetine (15 mg/kg/day) or clozapine (20 mg/kg/day) was measured in rats exposed to chronic social isolation and controls.…”

Section: Oxidative Stress In Liver Diseasesmentioning

confidence: 99%

The Role of Oxidative Stress and Antioxidants in Liver Diseases

Tan

Wang

et al. 2015

IJMS

1,422

918

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A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead to oxidative damage to tissue and organs. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury. A lot of risk factors, including alcohol, drugs, environmental pollutants and irradiation, may induce oxidative stress in liver, which in turn results in severe liver diseases, such as alcoholic liver disease and non-alcoholic steatohepatitis. Application of antioxidants signifies a rational curative strategy to prevent and cure liver diseases involving oxidative stress. Although conclusions drawn from clinical studies remain uncertain, animal studies have revealed the promising in vivo therapeutic effect of antioxidants on liver diseases. Natural antioxidants contained in edible or medicinal plants often possess strong antioxidant and free radical scavenging abilities as well as anti-inflammatory action, which are also supposed to be the basis of other bioactivities and health benefits. In this review, PubMed was extensively searched for literature research. The keywords for searching oxidative stress were free radicals, reactive oxygen, nitrogen species, anti-oxidative therapy, Chinese medicines, natural products, antioxidants and liver diseases. The literature, including ours, with studies on oxidative stress and anti-oxidative therapy in liver diseases were the focus. Various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases were summarized, questioned, and discussed.

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Section: Oxidative Stress In Liver Diseasesmentioning

confidence: 99%

The Role of Oxidative Stress and Antioxidants in Liver Diseases

Tan

Wang

et al. 2015

IJMS

1,422

918

View full text Add to dashboard Cite

show abstract

“…For example, doxorubicin and paclitaxel can increase thiobarbituric acid-reactive substance and docetaxel can reduce SOD activity [ 39 ]. Anti-inflammatory drugs, such as nimesulide, and nonsteroids can increase the activities of ALT, alkaline phosphatase, and aspartate aminotransferase (AST), but decrease the activity of SOD [ 42 ]. Evidence on the hepatic damage in patients due to drug-induced oxidative stress is insufficient.…”

Section: Factors Responsible For Oxidative Stress In the Livermentioning

confidence: 99%

Oxidative Stress, Genomic Integrity, and Liver Diseases

et al. 2022

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Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants. This imbalance can lead to malfunction or structure modification of major cellular molecules such as lipids, proteins, and DNAs. During oxidative stress conditions, DNA and protein structure modifications can lead to various diseases. Various antioxidant-specific gene expression and signal transduction pathways are activated during oxidative stress to maintain homeostasis and to protect organs from oxidative injury and damage. The liver is more vulnerable to oxidative conditions than other organs. Antioxidants, antioxidant-specific enzymes, and the regulation of the antioxidant responsive element (ARE) genes can act against chronic oxidative stress in the liver. ARE-mediated genes can act as the target site for averting/preventing liver diseases caused by oxidative stress. Identification of these ARE genes as markers will enable the early detection of liver diseases caused by oxidative conditions and help develop new therapeutic interventions. This literature review is focused on antioxidant-specific gene expression upon oxidative stress, the factors responsible for hepatic oxidative stress, liver response to redox signaling, oxidative stress and redox signaling in various liver diseases, and future aspects.

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“…YLSPS showed significant inhibition of pro-inflammation mediators such as tumor necrosis alpha (TNF-α) and interleukin-6 (IL-6). Protective effect of YLSPS in nimesulide-induced liver damage can be achieved thanks to its ability to reduce oxidative stress and prevent nimesulideinduced hepatotoxicity by inhibiting critical control points of apoptosis [61].…”

Section: Plant Millettia Pulchramentioning

confidence: 99%

Phytotherapy and Liver Disease

Čalkić¹

2019

Liver Cirrhosis - Debates and Current Challenges

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Hepatoprotective agents are medicines or dietary supplements that are used as an adjunct to the treatment of acute and chronic viral hepatitis, liver cirrhosis, hepatocellular carcinoma prevention, as well as other liver diseases. Experiments on animals and cell cultures have shown that natural compounds can alleviate and prevent pathological changes in the liver. In the past few years, considerable attention has been paid to medicinal herbs with hepatoprotective, antioxidant, and immune properties. The plants contain numerous phytochemicals, including polyphenols, phenolic acids, coumarins, styles, tannins, lignans, and lignins. These compounds include silymarin, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, glycyrrhizin, glycyrrhizin, berberine, luteolin, quercetin, coumarin derivatives (4-methylumbelliferone), and others. Many studies have been aimed at collecting data on some types of edible plants and fruits (grapefruit, cranberries, grapes, beets, cacti, chamomile, spirulina, propolis) that have shown hepatoprotective effects.

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Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice

Cited by 19 publications

References 28 publications

The Role of Oxidative Stress and Antioxidants in Liver Diseases

The Role of Oxidative Stress and Antioxidants in Liver Diseases

Oxidative Stress, Genomic Integrity, and Liver Diseases

Phytotherapy and Liver Disease

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