2008
DOI: 10.3923/ajbkr.2009.12.19
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Hepatoprotective Potential of Calcium and Magnesium Against Cadmium and Lead Induced Hepatotoxicity in Wistar Rats

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Cited by 21 publications
(12 citation statements)
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“…This result in agreement with previous studied, which carried on exposure to mercury chloride [110–114], and Ni [115]. Furthermore, this agrees with several investigators which reported that Cd and Pd administration increase aminotransferase, especially ALT, as a result of the necrotic lesion in the liver [114, 116, 117]. As seen in Figure 7(b), on the other hand, lead overloads stimulated oxidative damage in the liver tissue by causing oxidation of lipid.…”
Section: Discussionsupporting
confidence: 93%
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“…This result in agreement with previous studied, which carried on exposure to mercury chloride [110–114], and Ni [115]. Furthermore, this agrees with several investigators which reported that Cd and Pd administration increase aminotransferase, especially ALT, as a result of the necrotic lesion in the liver [114, 116, 117]. As seen in Figure 7(b), on the other hand, lead overloads stimulated oxidative damage in the liver tissue by causing oxidation of lipid.…”
Section: Discussionsupporting
confidence: 93%
“…This observation may be as a result of the injury inflicted on the liver; thereby making the proteins synthesized in the liver and spill out into the blood [116]. Also, this result is compatible with [119, 120].…”
Section: Discussionmentioning
confidence: 53%
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“…The increased activities of TBARS that were observed in the plasma of rats during Cd toxicity indicated a high degree of lipid peroxidation and oxidative stress. Although indirectly involved in the generation of free radicals, lipid peroxidation is considered a primary mechanism for Cd-induced toxicity [ 37 - 40 ]. The toxic effects of Cd are exerted through oxidative damage to cellular organelles by inducing the generation of ROS [ 41 ], which consist mainly of O 2 + , H 2 O 2 – and OH + [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Ge also possesses antioxidative property [9] and suppresses tumor progression [10]. In addition, beneficial effects of Se, Ge, Sn, Mg, and Ca on liver function have been reported [11,12,13,14].…”
Section: Introductionmentioning
confidence: 99%