HER2/neu Expression in Relation to Clinicopathologic Features of Breast Cancer Patients

Traina, Adele; Agostara, Biagio; Marasà, L; Calabrò, Maurizio; Zarcone, Maurizio; Carruba, Giuseppe

doi:10.1196/annals.1386.029

Cited by 20 publications

(20 citation statements)

References 23 publications

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“…The signifi cance of amplifi ed oncogene in breast cancer has been the subject of debate. HER-2/neu(Cerb-B-2) is the gene known to show the highest frequency of amplifi cation, and has in several reports been associated with breast carcinoma progression and clinically aggressive behaviour of BC [22][23][24][25][26][27][28][29][30]. There was inverse relationship in between HER-2/neu over expression and ER/PR receptor status (table 4), similar observation also revealed by other studies [26,27].…”

Section: Discussionsupporting

confidence: 73%

“…This indicates poor prognosis of our patients and this is again supported by lower hormone receptor expression on our patients which is 25-27% in comparison >50% in most western literature [26]. One possibility of difference in incidence of HER-2/neu could be because 1+ staining detected in immunohistochemical technique is regarded as negative by FISH technique, but many series are showing similar low incidence despite of not grading the stain.…”

Section: Discussionmentioning

confidence: 65%

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Significance of Her-2/neu protein over expression in Indian breast cancer patients

et al. 2007

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Background Racial disparity in presentation and outcome of breast cancer is established but cause is unexplained . Many studies show various molecular markers for racial differences in the prognosis of breast cancer. There is scarcity of data on prognostic signifi cance of HER-2/neu in Indian breast cancer. Aims and ObjectiveTo know incidence and prognostic signifi cance of HER-2/neu expression in Indian patients.To correlate HER-2/neu Expression with other prognostic markers and ER/PR Receptor status. Statistical Analysis Data was analyzed by univariate and multivariate analysis for all prognostic factors. Signifi cance was calculated by using Chi square test and survival analysis by using Kaplan Meier survival curve. Material and MethodsResults The median age of 112 patients was 46.56 (±9.55) years. HER-2/neu over expression was present in 46.37%. Signifi cant correlation was found between HER-2/neu over expression and lymph node status, grade of tumor and ER/ PR receptor status. Median follow up period of 23 months. There was signifi cant tumour free survival advantage (p < 0.01) and overall survival advantage (p < 0.001) in patients with HER-2/neu negative expression.Conclusion HER-2/neu oncogene over expression is higher (46.37%) among Indian patients in comparison to 25-30% shown in most western literature. HER-2/neu oncogene over expression signifi cantly correlates with grade, lymph node involvement, ER/PR status and also affects survival.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 65%

Significance of Her-2/neu protein over expression in Indian breast cancer patients

et al. 2007

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“…This group appeared to represent an aggressive form of breast cancer, presenting at a younger age with large tumor size. Despite the great variation in levels of HER-2/neu positivity, nearly all investigators report a negative relationship between HER-2/neu status and steroid receptors levels [6,7,8,9] This inverse association has been linked to the fact that estrogens and its receptor are required to suppress HER-2. This leads to lower or absent hormone receptors in women with HER-2/neu positive breast cancers.…”

Section: Association Of Her-2/neu Receptor Status With Agementioning

confidence: 99%

Study of ER, PR & HER-2/NEU reactivity pattern in the patient of Breast Cancer in northern part of india

Jain¹,

Aggrawal²,

Ameta³

et al. 2014

IOSRJDMS

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“…Another study (Menard et al, 2002) found in 1,928 patients that tumor size (﹥2 cm) correlated closely with poor outcome of HER-2 overexprssed breast cancer. A third study (Traina et al, 2006) had the same conclusion from a study in 1,355 patients with early breast carcinoma. Our result was similar: patients with a tumor greater than 2 cm had significant reduction in OS (p=0.015) and DFS (p=0.019).…”

Section: Discussionmentioning

confidence: 52%

Clinicopathologic Characteristics and Prognostic Factors in Patients with Operable HER-2 Overexpressing Breast Cancer

Liu

Park²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To study the relationship between clinical pathologic characteristics, treatment modalities and prognostic factors in HER-2 (Human Epidermal growth factor Receptor-2) overexpressed breast carcinoma. Materials and Methods: Major clinico-pathological factors including therapeutic modalities and survival status of 371 breast cancer patients with HER2 over-expression, teated at Yantai Yuhuangding Hospital from March of 2002 to December of 2010 were retrospectively studied, with special attention focused on survival-related factors. Results: The median age of the total 371 patients in this study was 48 years at time of diagnosis, among which, the leading pathological type was infiltrating ductal carcinoma (92.5%); 62.8% presented with a primary tomor larger than 2 cm in diameter at diagnosis, 51.0% had axillary lymph node (ALN) metastases; ER (Estrogen receptor) /PR (Progesterone receptor) double negative occured in 52.8% of cases, and PCNA (proliferation cell nuclear antigen) (+++) was found in 55.1%. HER-2 overexpressed patients were usually in advanced stage when the diagnosis was made (72.8% at stages ⅡA~ⅢC). The prognosis and survival were assessed in 259 patients with complete follow-up data. 5-year DFS (disease-free survival) and OS (overall survival) rate was 68.0% and 78.0% respectively. Univariate analysis revealed that age, tumor size, ALN metastases, LVSI (lymph-vascular space involvement), PCNA status, hormonal therapy, chemotherapy cycles, and HER-2 overexpression, correlated closely with the prognosis. ALN metastases, LVSI, PCNA status and chemotherapy cycles were independent predictors of survival. Conclusions: HER-2 overexpressed breast cancer has special clinical and pathological characteristics, with advanced clinical stages and high rate of ER/PR double negative. Lymph node metastases, LVSI, PCNA and chemotherapy cycles are independent predictors of prognosis.

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HER2/neu Expression in Relation to Clinicopathologic Features of Breast Cancer Patients

Cited by 20 publications

References 23 publications

Significance of Her-2/neu protein over expression in Indian breast cancer patients

Significance of Her-2/neu protein over expression in Indian breast cancer patients

Study of ER, PR & HER-2/NEU reactivity pattern in the patient of Breast Cancer in northern part of india

Clinicopathologic Characteristics and Prognostic Factors in Patients with Operable HER-2 Overexpressing Breast Cancer

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