Herbal Medicine in Mexico: A Cause of Hepatotoxicity. A Critical Review

Valdivia-Correa, Bárbara; Gómez-Gutiérrez, Cristina; Uribe, Misael; Méndez-Sánchez, Nahúm

doi:10.3390/ijms17020235

“…New investigations have focused on discovering agents derived from synthetic and natural products to handle bacterial pathogenesis by means of QSS-I (Pan & Ren 2009). In Mexico around 4,000-5,000 species of plants have medicinal properties which are frequently used to treat disorders (Espinosa et al 2008, Valdivia-Correa et al 2016. The bark of "pochote" or "pochotl" trees is widely used in therapeutic applications.…”

mentioning

confidence: 99%

Phytochemical screening and anti-virulence properties of Ceiba pentandra and Ceiba aesculifolia (Malvaceae) bark extracts and fractions

Muñoz-Cázares

¹

,

Aguilar-Rodríguez

²

,

García‐Contreras

³

et al. 2018

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Background: Inhibition of quorum sensing systems (QSS-I) is a novel strategy in the treatment of bacterial infections. To date, plants are the major source of metabolites with this inhibitory activity. Thus, species of Mexican flora can be important resources for obtaining metabolites with QSS-I activity.Hypothesis: We hypothesized that extracts from species of the genus Ceiba have metabolites with inhibitory activity against bacterial quorum sensing systems.Species studied: Ceiba pentandra (L.) Gaertn. and Ceiba aesculifolia (Kunth) Britten & Baker f. (Malvaceae).Study site and years of study: We collected Ceiba bark in the municipalities of Tierra Blanca, Veracruz, and Acatlan, Oaxaca, in August 2013.Methods: We determined the effect of extracts from C. aesculifolia and C. pentandra against QSS-regulated phenotypes of Chromobacterium violaceum and Pseudomonas aeruginosa. Extracts were fractionated and the main metabolites were identified. As support in the identification of the species, we carried out an anatomical study of the bark.Results: Hexane and dichloromethane extracts of both species of Ceiba exhibited QSS-I activity. We identified four fractions rich in terpene and sterol compounds with the ability to attenuate virulence factors in P. aerugiosa. The histological analysis appears to support the presence of some differences in the barks that can facilitate identification of the two species.Conclusions: The extracts and fractions of the two species of Ceiba are sources of phytochemicals with the ability to regulate bacterial quorum sensing systems positively or negatively.

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“…Figure 3 depicts a variety of theories related to the pathogenesis of HILI. The overlap is mostly with those for DILI in host, herb-drug supplements (HDS), and environment factors [16,51]. Up to date, a large portion of medicines used in developing countries are herb drugs.…”

Section: Risk Factors and Future Challenges On Hili Researchmentioning

confidence: 99%

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Kim¹,

Kim²,

Go³

et al. 2017

J Int Korean Med

0

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In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

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“… Figure 3 depicts a variety of theories related to the pathogenesis of HILI. The overlap is mostly with those for DILI in host, herb-drug supplements (HDS), and environment factors [16, 51]. …”

Section: Diagnosis and Treatment Of Hili In Chinamentioning

confidence: 99%

Research Advances on Hepatotoxicity of Herbal Medicines in China

Liu

¹

,

Fan

²

,

Li

³

et al. 2016

BioMed Research International

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In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

show abstract

Herbal Medicine in Mexico: A Cause of Hepatotoxicity. A Critical Review

Cited by 47 publications

References 27 publications

Phytochemical screening and anti-virulence properties of <em>Ceiba pentandra</em> and <em>Ceiba aesculifolia</em> (Malvaceae) bark extracts and fractions

Phytochemical screening and anti-virulence properties of <em>Ceiba pentandra</em> and <em>Ceiba aesculifolia</em> (Malvaceae) bark extracts and fractions

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Research Advances on Hepatotoxicity of Herbal Medicines in China

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