2014
DOI: 10.4077/cjp.2014.bab147
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Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis

Abstract: Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis. The purpose of this study is to determine whether further CCl₄ treatment would induce cardiac cell fibrosis. The cardiac tissues were analyzed by H&E. histological staining, Trichrome Masson staining and Western blotting. The results showed that the CCl₄-treated-only group exhibits more trichrome staining, meaning that more fibrosis is present. Moreover, CCl₄ could further induce cardiac-fibrosis via… Show more

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Cited by 12 publications
(12 citation statements)
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“…Damaged cardiomyocytes releases higher levels of TGF β1 that binds to cell surface TGF β receptor that eventually modulates CTGF gene expression. CTGF protein induces downstream fibrosis protein MMP‐2, MMP‐9, and COL1A1 thereby enhances cardiac fibrosis (Kuo et al, ; Arauz et al, ; Drygiannakis et al, ; Chang et al, ; Islam et al, ; Yang et al, ; Lai et al, ). Our results further reveal that doxorubicin induced cardiac damage resulted in progression to cardiac fibrosis in the rat models.…”
Section: Discussionmentioning
confidence: 99%
“…Damaged cardiomyocytes releases higher levels of TGF β1 that binds to cell surface TGF β receptor that eventually modulates CTGF gene expression. CTGF protein induces downstream fibrosis protein MMP‐2, MMP‐9, and COL1A1 thereby enhances cardiac fibrosis (Kuo et al, ; Arauz et al, ; Drygiannakis et al, ; Chang et al, ; Islam et al, ; Yang et al, ; Lai et al, ). Our results further reveal that doxorubicin induced cardiac damage resulted in progression to cardiac fibrosis in the rat models.…”
Section: Discussionmentioning
confidence: 99%
“…It is well established that CCl4 inhibits AO enzymes (SOD, GSH-Px and CAT) and GSH in liver samples [ 80 ], increases the secretion of ALT, aspartate transaminase (AST) and ALP due to hepatic injuries caused by ROS [ 81 ] and enhances TBARS in the liver [ 82 ] and serum [ 83 ]. It has been shown that practically all elevated indexes of the oxidative stress caused by CCl4 were restored almost to the initial physiological levels by SM treatment (25–100 mg/kg/BW) [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] and hepatic injuries were significantly decreased. It is important to mention that in a model system based on CCl4-induced liver fibrosis in mice, microarray analysis showed that SM downregulated the expression levels of cytoskeleton organization genes and mitochondrion electron-transfer chain genes, such as cytochrome c oxidase, Cox6a2, Cox7a1, and Cox8b genes [ 88 ].…”
Section: Antioxidant Properties Of Silymarin (Sm)mentioning
confidence: 99%
“…OGE also modulates the immune response [20] and possess anticancer [21][22][23][24][25][26] and antibacterial activities [27]. OGE, with its many antioxidant components, can also protect body organs from free radical damage and oxidative stress [28][29][30][31][32][33][34][35][36][37]. We speculated that OGE can prevent UVC damage, and that this property can be applied to wound care.…”
Section: Ivyspringmentioning
confidence: 99%