Herbal treatment following post‐seizure induction in rat by lithium pilocarpine: Scutellaria lateriﬂora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures

Peredery, Oksana; Persinger, Michael A.

doi:10.1002/ptr.1511

Cited by 35 publications

(13 citation statements)

References 15 publications

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“…During the Three Kingdom Period (220–265 A.D.),its use as the first anesthetic for surgery was recorded in literatures [40]. Modern studies showed that D. stramonium had varieties of pharmacological effects including antiasthmatic [41], antiepileptic [42], antioxidant [43], antimicrobial [44], [45], antifungal [46] and anti-inflammatory [47] activities. Approximately 400 complete cp genome sequences have been sequenced in GenBank.…”

Section: Discussionmentioning

confidence: 99%

Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering

Yang

Dang

et al. 2014

PLoS ONE

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Datura stramonium is a widely used poisonous plant with great medicinal and economic value. Its chloroplast (cp) genome is 155,871 bp in length with a typical quadripartite structure of the large (LSC, 86,302 bp) and small (SSC, 18,367 bp) single-copy regions, separated by a pair of inverted repeats (IRs, 25,601 bp). The genome contains 113 unique genes, including 80 protein-coding genes, 29 tRNAs and four rRNAs. A total of 11 forward, 9 palindromic and 13 tandem repeats were detected in the D. stramonium cp genome. Most simple sequence repeats (SSR) are AT-rich and are less abundant in coding regions than in non-coding regions. Both SSRs and GC content were unevenly distributed in the entire cp genome. All preferred synonymous codons were found to use A/T ending codons. The difference in GC contents of entire genomes and of the three-codon positions suggests that the D. stramonium cp genome might possess different genomic organization, in part due to different mutational pressures. The five most divergent coding regions and four non-coding regions (trnH-psbA, rps4-trnS, ndhD-ccsA, and ndhI-ndhG) were identified using whole plastome alignment, which can be used to develop molecular markers for phylogenetics and barcoding studies within the Solanaceae. Phylogenetic analysis based on 68 protein-coding genes supported Datura as a sister to Solanum. This study provides valuable information for phylogenetic and cp genetic engineering studies of this poisonous and medicinal plant.

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Section: Discussionmentioning

confidence: 99%

Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering

Yang

Dang

et al. 2014

PLoS ONE

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“…There are two studies which show that Gelsemium can have a preventive action against experimental stress (electric shock) in mice 23 or against convulsions provoked by lithium and pilocarpine in rats. 46 It should be noted, that the latter protective effect against convulsions was obtained using a pure extract (24 drops/2 l of drinking water), rather than a homeopathic dilution, mixed with Scutellaria lateriflora (Skullcap) and Datura stramonium (Jimson Weed).…”

Section: Effects In Animal Modelsmentioning

confidence: 99%

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

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The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple laboratories, and concern Ignatia, Gelsemium, Chamomilla (in homeopathic dilutions/potencies). Nevertheless, there are some interesting results pointing to the possible efficacy of other remedies, and confirming a statistically significant effect of high dilutions of neurotrophic molecules and antibodies. In the second part of this paper we report some recent results obtained in our laboratory, testing Aconitum, Nux vomica, Belladonna, Argentum nitricum, Tabacum (all 5CH potency) and Gelsemium (5, 7, 9 and 30CH potencies) on mice using ethological models of behaviour. The test was performed using coded drugs and controls in double blind (operations and calculations). After an initial screening that showed all the tested remedies (except for Belladonna) to have some effects on the behavioural parameters (light-dark test and open-field test), but with high experimental variability, we focused our study on Gelsemium, and carried out two complete series of experiments. The results showed that Gelsemium had several effects on the exploratory behaviour of mice, which in some models were highly statistically significant (p < 0.001), in all the dilutions/dynamizations used, but with complex differences according to the experimental conditions and test performed. Finally, some methodological issues of animal research in this field of homeopathy are discussed. The "Gelsemium model" - encompassing experimental studies in vitro and in vivo from different laboratories and with different methods, including significant effects of its major active principle gelsemine - may play a pivotal rule for investigations on other homeopathic remedies.

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“…Used by Zulu as a hypnotic drug against hysteria and as a 'diviner's aid' (Pooley, 2005). Continously treatment with a weak solution of Datura stramonium, Gelsemium sempervirens* and Scutellaria L. (Lamiaceae)* showed possible antiepileptogenic effect in rats (Peredery and Persinger, 2004)…”

Section: Simaroubaceaementioning

confidence: 98%

“…Peredery and Persinger (2004) demonstrated a possible antiepileptogenic effect of a weak solution of Datura stramonium L. (Solanaceae), Gelsemium sempervirens L. (Loganiaceae) Scutellaria lateri flora continuously administrated after lithium pilocarpin induced SE in rats. Interestingly, after removal of extract administration the animals displayed numbers of spontaneous seizures comparable to control group.…”

Section: Crinum Speciesmentioning

confidence: 99%

Review on plants with CNS-effects used in traditional South African medicine against mental diseases

Stafford

Pedersen

Staden

et al. 2008

Journal of Ethnopharmacology

200

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Herbal treatment following post‐seizure induction in rat by lithium pilocarpine: Scutellaria lateriﬂora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures

Cited by 35 publications

References 15 publications

Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering

Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Review on plants with CNS-effects used in traditional South African medicine against mental diseases

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