Heritability of resistance to bacterial infection in meat rabbits

Eady, Sandra; Garreau, Hervé; Gilmour, A.

doi:10.1016/j.livsci.2007.01.158

Cited by 16 publications

(23 citation statements)

References 15 publications

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“…A heritability of 0.08 ± 0.02 was found for ALLDIG in the AGP39 rabbit line with 53,222 records analyzed from 1999 to 2007 with a threshold model (Garreau et al, 2008). Heritability of bacterial infectious syndromes at 9 or 10 wk of age estimated with a linear model was 0.04 ± 0.01 in French meat rabbit populations (Eady et al, 2004) and 0.06 ± 0.02 in Australian meat rabbit populations (Eady et al, 2007).…”

Section: Selection For Disease Syndromesmentioning

confidence: 99%

“…and Staphylococcus spp. (Eady et al, 2007) as well as their resistance to digestive disorders by using simple records of disease syndromes (Garreau et al, 2008). However, little is known about the genetic correlations among various disease traits and between disease and production traits.…”

Section: Resistance To Infectious Diseases Is a Heritablementioning

confidence: 99%

“…Our results are in accordance with those of previous studies in commercial meat rabbits. These studies showed that disease traits grouping digestive syndromes on the one hand (Garreau et al, 2008) and bacterial infectious syndromes (from Pasteurella multocida or Staphylococcus aureus) on the other hand (Eady et al, 2004(Eady et al, , 2007 are heritable. A heritability of 0.08 ± 0.02 was found for ALLDIG in the AGP39 rabbit line with 53,222 records analyzed from 1999 to 2007 with a threshold model (Garreau et al, 2008).…”

Section: Selection For Disease Syndromesmentioning

confidence: 99%

See 2 more Smart Citations

Resistance to infectious diseases is a heritable trait in rabbits1

Gunia

David

Hurtaud³

et al. 2015

Journal of Animal Science

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Selection for disease resistance is a powerful way to improve the health status of herds and to reduce the use of antibiotics. The objectives of this study were to estimate 1) the genetic parameters for simple visually assessed disease syndromes and for a composite trait of resistance to infectious disease including all syndromes and 2) their genetic correlations with production traits in a rabbit population. Disease symptoms were recorded in the selection herds of 2 commercial paternal rabbit lines during weighing at the end of the test (63 and 70 d of age, respectively). Causes of mortality occurring before these dates were also recorded. Seven disease traits were analyzed: 3 elementary traits visually assessed by technicians on farm (diarrhea, various digestive syndromes, and respiratory syndromes), 2 composite traits (all digestive syndromes and all infectious syndromes), and 2 mortality traits (digestive mortality and infectious mortality). Each animal was assigned only 1 disease trait, corresponding to the main syndrome ( = 153,400). Four production traits were also recorded: live weight the day before the end of test on most animals ( = 137,860) and cold carcass weight, carcass yield, and perirenal fat percentage of the carcass on a subset of slaughtered animals ( = 13,765). Records on both lines were analyzed simultaneously using bivariate linear animal models after validation of consistency with threshold models applied to logit-transformed traits. The heritabilities were low for disease traits, from 0.01 ± 0.002 for various digestive syndromes to 0.04 ± 0.004 for infectious mortality, and moderate to high for production traits. The genetic correlations between digestive syndromes were high and positive, whereas digestive and respiratory syndromes were slightly negatively correlated. The genetic correlations between the composite infectious disease trait and digestive or respiratory syndromes were moderate. Genetic correlations between disease and production traits were favorable. Our results indicate that it is possible to select rabbits using visually assessed disease syndromes without the need for a trade-off between health and production traits. Using a composite criterion that includes all infectious syndromes is easy to implement and heritable and is, therefore, a promising way to improve the general disease resistance in livestock species.

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Section: Selection For Disease Syndromesmentioning

confidence: 99%

Section: Resistance To Infectious Diseases Is a Heritablementioning

confidence: 99%

Section: Selection For Disease Syndromesmentioning

confidence: 99%

See 1 more Smart Citation

Resistance to infectious diseases is a heritable trait in rabbits1

Gunia

David

Hurtaud³

et al. 2015

Journal of Animal Science

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“…Les analyses en cours laissent présager l'existence d'un déterminisme génétique de la résistance à la Pasteurellose (Gunia et al, 2017). Ces résultats obtenus dans des conditions d'infection expérimentale confirment ceux déjà obtenus dans des condition d'infection naturelle (Eady et al, 2007 ;Gunia et al, 2015).…”

Section: Projets Et Perspectivesunclassified

La génomique du lapin : avancées, applications et perspectives

Garreau

Gunia

2018

INRA Prod. Anim.

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L’évolution récente des technologies de séquençage et l’apport de la génomique a révolutionné nos connaissances sur les génomes et leurs polymorphismes, et permis d’élaborer des outils de génotypage qui accélèrent l’identification de polymorphismes causaux et contribuent à améliorer significativement le progrès génétique réalisé chez certaines espèces d’élevage, en particulier les bovins laitiers. Le séquençage complet du génome du lapin réalisé par le « Broad Institute » (Boston, USA), avec l’appui d’un consortium international auquel a contribué l’INRA, a été publié en 2014. Les résultats obtenus ont apporté un éclairage nouveau sur l’évolution et la domestication du lapin. En 2016, dans le cadre d’un projet Européen (COST Action TD1101 « A Collaborative European Network on Rabbit Genome Biology – RGB-Net »), une puce de génotypage avec 200000 SNP (« Single-Nucleotide Polymorphism ») a été développée, permettant de renouveler les approches de génétique chez le lapin. L’objet de cette synthèse est de faire le point sur les connaissances relatives au génome du lapin et d’établir un inventaire des gènes ou régions génomiques liés à certaines fonctions ou caractères d’intérêt dans cette espèce. Nous décrivons ici le principe des outils (cartes génétiques, puces SNP, séquençage) et des méthodes (détection de QTL, approche gènes candidats, identification de mutations causales) qui ont déjà été appliqués chez le lapin. Nous illustrons les perspectives d’utilisation des outils maintenant disponibles pour la sélection avec deux projets de recherche portant sur la résistance aux maladies et l’efficacité alimentaire. Une réflexion prospective sur la sélection génomique est également proposée.

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“…However, concerns about increasing antibiotic resistance led to bans on subtherapeutic antibiotics usage in the European Union in 2006 (Cully, 2014). As a result, improving host genetic resistance to digestive disorders may be an efficient and sustainable method in the modern rabbit production because of the existence of individual genetic predisposition which is based on epidemiologic features (Eady et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The polymorphism and gene expression of chemokine receptor 6 is associated with digestive disorders in rabbits

Zhong

Chen

et al. 2016

IJAR

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This study aimed to investigate the possible involvement of Chemokine receptor 6 (CCR6) gene in genetic susceptibility to digestive disorders in rabbits. A total of 346 samples (161 cases vs 185 controls) were used for this case-control association study. One coding SNP (c.96C>T) spanning the CCR6 gene coding region was identified by direct sequencing and then genotyped using PCR-SSCP. The results revealed that individuals with allele "T" was significantly protective against digestive disorders (odds ratio=0.66, 95% confidence interval: 0.46-0.94, P<0.05), and TC/TT genotype can significantly reduce the incidence of digestive disorders (odds ratio=0.64, 95% CI: 0.41-0.99, P<0.05). we also investigated CCR6 gene mRNA expression level in different severity status of digestive disorders. The significantly higher mRNA expression level of sacculus rotundus in severe group was observed compared with mild and health group (P<0.05), in addition, the individuals with CC genotype had a higher mRNA expression than TC and TT genotype (P<0.05).

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Heritability of resistance to bacterial infection in meat rabbits

Cited by 16 publications

References 15 publications

Resistance to infectious diseases is a heritable trait in rabbits1

Resistance to infectious diseases is a heritable trait in rabbits1

La génomique du lapin : avancées, applications et perspectives

The polymorphism and gene expression of chemokine receptor 6 is associated with digestive disorders in rabbits

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