Herpes Simplex Treatment with IDU and Corticosteroids

Acyclovir treatment in stromal herpetic keratitis

“…In 7 cases (4, 5, 8, 12, 13, 26 and 30) corneal stromal oedema reappeared, presumably due to premature discontinuation of the corticosteroid eyedrops. These eyes responded favourably to renewed corticosteroid instillation; it appeared that prolonged low-dose steroid therapy was required, as was also reported by Kaufman et al (1963).…”

Diagnosis of viral disease and the advent of antiviral drugs

“…Most cases of adenoviral conjunctivitis are mild and self-limiting and permanent eye damage seems very rare. There have been occasions when varicella-zoster virus and even the poxviruses, such as the vaccine virus for smallpox, have infected the eye and in these cases the antiherpetic ophthalmic preparations seem helpful (Jones and Ai-Hussaini, 1963 ;Jack and Sorenson, 1963 ;Kaufman et al, 1963). Recently, in certain areas of the world, eye infections associated with enterovirus 70 have been detected, and likely certain other enteroviruses can cause a similar problem (Arnow et al, 1977).…”

Management of acute necrotizing encephalitis: a review of 369 cases

“…On the other hand, the deleterious effect of steroids in viral infections has often been stressed (Findley & Howard, 1952;Kilbourne, 1955a;Immam & Hammon 1957a;Kilbourne, 1957;Coid, Tobin & Beswick, 1960;Weinstein, 1962;Rook, Wilkinson & Ebling, 1968;Toole & McCall, 1969;Longson & Beswick, 1971) and especially in herpes simplex keratitis (Jawetz, Okumoto & Sonne, 1959;Baron, Le Bourhis & Gouray, 1959;McCoy & Leopold, 1960;Bonamour, 1962;Kaufman & Maloney, 1962;Kaufman, Martola & Dohlman, 1963;Schneweis, Neuberger & Meyer, 1963;Crompton, 1964;Duke-Elder, 1965;Maloney & Kaufman, 1965;Patterson & Jones, 1967).…”